Role of Echocardiography in the Assessment of Cardiac Involvement in Takayasu Arteritis

Abstract

Background: The aim of this study is to investigate echocardiographic features of patients with cardiac involvement and evaluate the value of echocardiography in Takayasu arteritis (TA). Methods:All patients with TA admitted from January 2015 to December 2021 were classified into patients with cardiac involvement (group 1, n=68) and patients without cardiac involvement (group 2, n=59). This retrospective study compared the clinical manifestations and echocardiographic parameters between the two groups and further explored the relationship between pulmonary hypertension (PH) and echocardiographic parameters. Clinical, imaging and laboratory results of the TA patients were obtained from hospital files. Results: In our study, 68 patients (53.54%) had cardiac involvement. Valvular abnormalities were found in 55 (80.88%) patients in group 1, coronary artery abnormalities in 10 (14.71%), myocardial abnormalities in 18 (26.47%) and PH in 11 patients (16.18%), respectively. Compared to group 2, both TA patients in group 1 associated with and without PH presented with the significantly differences of echocardiographic parameters regarding left atrial diameter (LAD), interventricular septum thickness (IVST), left ventricular posterior wall thickness (LVPWT), left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic dimension (LVESD), left ventricular ejection fraction (LVEF), left ventricular (LV) mass, LV mass/body surface area (BSA), main pulmonary artery diameter (MPAD) (P<0.05). Compared the echocardiographic parameters between the patients with and without PH in group 1, the differences were of no statistical significance (P>0.05). Conclusions: Cardiac involvement is not infrequent in TA patients and it should be carefully evaluated. Echocardiography plays a vital role in the assessment of cardiac involvement in TA which is helpful for diagnosis and management of TA.

Myocardial and Vascular Involvement in Patients with Takayasu Arteritis: A Cardiovascular MRI Study

“…The most frequent conditions were myocarditis, identified in six patients, and severe aortic regurgitation, observed in two cases. In line with our study, previous studies reported myocardial involvement in approximately 25 to 53% of TA patients in various studies [28,30,31]. It was suggested that myocardial involvement in TA patients might be associated with factors such as early age of disease onset, lack of classic risk factors, and more active disease [30].…”