Role of dyslipidemia in impairment of energy metabolism, oxidative stress, inflammation and cardiovascular disease in chronic kidney disease

Vaziri, Nosratola D.

doi:10.1007/s10157-013-0847-z

Cited by 77 publications

(76 citation statements)

References 48 publications

(49 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nevertheless, it is also critical to note that these associations are not necessarily indicative of a causal relationship and may be surrogates for unidentified mechanisms that can link energy metabolism, lipoproteins, and outcomes in ESRD. 40 Therefore, our findings may provide important clues for future investigations aimed at deciphering the role of triglycerides and triglyceride-rich lipoproteins in ESRD-related cardiovascular and overall outcomes. Finally, another important potential explanation for the seemingly paradoxical associations between serum non-HDL-C levels and mortality in patients undergoing hemodialysis is the time dependency of the deleterious effects imparted by these lipoproteins.…”

Section: Discussionmentioning

confidence: 99%

Inverse Association Between Serum Non–High‐Density Lipoprotein Cholesterol Levels and Mortality in Patients Undergoing Incident Hemodialysis

Chang

Streja

et al. 2018

JAHA

Self Cite

View full text Add to dashboard Cite

Background There is accumulating evidence that serum levels of non–high‐density lipoprotein cholesterol (non– HDL ‐C) are a more accurate predictor of cardiovascular outcomes when compared with low‐density lipoprotein cholesterol. However, we recently found that higher serum concentrations of triglycerides are associated with better outcomes in patients undergoing hemodialysis. Therefore, we hypothesized that the association of serum levels of non– HDL ‐C (which includes triglyceride‐rich lipoproteins) with outcomes may also be different in patients undergoing hemodialysis when compared with other patient populations. Methods and Results We studied the association of baseline and time‐dependent serum levels of non– HDL ‐C with all‐cause and cardiovascular mortality using Cox proportional hazard regression models in a nationally representative cohort of 50 118 patients undergoing incident hemodialysis from January 1, 2007, to December 31, 2011. In time‐dependent models adjusted for case mix and surrogates of malnutrition and inflammation, a graded inverse association between non– HDL ‐C level and mortality was demonstrated with hazard ratios (95% confidence intervals) of the lowest (<60 mg/dL) and highest (≥160 mg/dL) categories: 1.88 (1.72–2.06) and 0.73 (0.64–0.83) for all‐cause mortality and 2.07 (1.78–2.41) and 0.75 (0.60–0.93) for cardiovascular mortality, respectively (reference, 100–115 mg/dL). In analyses using baseline values, non– HDL ‐C levels <100 mg/dL were also associated with significantly higher mortality risk across all levels of adjustment. Similar associations were found when evaluating non‐ HDL / HDL cholesterol ratio and mortality, with the highest all‐cause and cardiovascular mortality being observed in patients with decreased non‐ HDL / HDL‐C ratio (<2.5). Conclusions Contrary to the general population, decrements in non– HDL ‐C and non‐ HDL / HDL cholesterol ratio were paradoxically associated with increased all‐cause and cardiovascular mortality in patients undergoing incident hemodialysis. The underlying mechanisms responsible for these associations await further investigation.

show abstract

Section: Discussionmentioning

confidence: 99%

Inverse Association Between Serum Non–High‐Density Lipoprotein Cholesterol Levels and Mortality in Patients Undergoing Incident Hemodialysis

Chang

Streja

et al. 2018

JAHA

Self Cite

View full text Add to dashboard Cite

show abstract

“…The scarcity of cholesterol ester-rich HDL in nephrotic syndrome contributes to an impairment of VLDL and chylo micron metabolism, and limits the delivery of lipids to myocytes for energy production and to adipose tissue for storage 48 . The contribution of HDL abnormalities to the pathogenesis of impaired VLDL metabolism in nephrotic syndrome has been clearly demonstrated in vivo, where impaired endothelial binding and LPLmediated lipolysis of VLDL in nephrotic rats could be corrected by infusion of HDL from healthy animals 49,50 .…”

Section: Consequences Hdl Abnormalitiesmentioning

confidence: 99%

HDL abnormalities in nephrotic syndrome and chronic kidney disease

2015

Self Cite

View full text Add to dashboard Cite

| Normal HDL activity confers cardiovascular and overall protection by mediating reverse cholesterol transport and through its potent anti-inflammatory, antioxidant, and antithrombotic functions. Serum lipid profile, as well as various aspects of HDL metabolism, structure, and function can be profoundly altered in patients with nephrotic range proteinuria or chronic kidney disease (CKD). These abnormalities can, in turn, contribute to the progression of cardiovascular complications and various other comorbidities, such as foam cell formation, atherosclerosis, and/or glomerulosclerosis, in affected patients. The presence and severity of proteinuria and renal insufficiency, as well as dietary and drug regimens, pre-existing genetic disorders of lipid metabolism, and renal replacement therapies (including haemodialysis, peritoneal dialysis, and renal transplantation) determine the natural history of lipid disorders in patients with kidney disease. Despite the adverse effects associated with dysregulated reverse cholesterol transport and advances in our understanding of the underlying mechanisms, safe and effective therapeutic interventions are currently lacking. This Review provides an overview of HDL metabolism under normal conditions, and discusses the features, mechanisms, and consequences of HDL abnormalities in patients with nephrotic syndrome or advanced CKD.

show abstract

“…25 A recent review supported the use of probiotics in at least those patients with an end-stage kidney disease. 26 Several in vivo studies demonstrated that some Lactobacillus strains can improve the antioxidant status of rats and humans, and could decrease the risk of accumulation of ROS. Therefore, many investigations focused on antioxidant properties of LAB and their role in health and disease recently.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of probioticLactobacillus plantarumBJ0021 on liver and kidney oxidative stress and apoptosis induced by endosulfan in pregnant rats

et al. 2015

View full text Add to dashboard Cite

Endosulfan (EDS) is one of the most widely organochlorine insecticide used in many parts of the world, although it is currently banned or severely restricted in use in some countries. EDS causes a variety of negative effects in non-target species including humans. Therefore, the aim of the present study was to investigate the possible protective effects of Lactobacillus plantarum BJ0021 on toxicity, oxidative stress, and apoptosis induced by EDS intoxication on liver and kidneys of pregnant rats. This pesticide induced a significant increase in total cholesterol, alanine-amino transferase (ALAT), aspartate-amino transferase (ASAT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), urea and creatinine in serum, while urinary urea and creatinine were lower than those of the control group. In the liver and kidney, lipid peroxidation increased significantly, the antioxidant levels, such as superoxide dismutase (SOD) and catalase (CAT) were markedly depressed and TdT-mediated dUTP-biotin Nick End Labeling (TUNEL) revealed more apoptotic cells. In contrast, co-administration of L. plantarum BJ0021 to EDS-treated animals ameliorated most of these biochemical parameters, but the activity of antioxidant enzymes (SOD, CAT) did not modify and the number of apoptotic nuclei remained significantly raised in kidney compared to control. In conclusion, the administration of L. plantarum BJ0021 decreased apoptosis and might play a protective role in reducing toxicity of EDS in pregnant rats.

show abstract

Role of dyslipidemia in impairment of energy metabolism, oxidative stress, inflammation and cardiovascular disease in chronic kidney disease

Cited by 77 publications

References 48 publications

Inverse Association Between Serum Non–High‐Density Lipoprotein Cholesterol Levels and Mortality in Patients Undergoing Incident Hemodialysis

Inverse Association Between Serum Non–High‐Density Lipoprotein Cholesterol Levels and Mortality in Patients Undergoing Incident Hemodialysis

HDL abnormalities in nephrotic syndrome and chronic kidney disease

Protective effects of probioticLactobacillus plantarumBJ0021 on liver and kidney oxidative stress and apoptosis induced by endosulfan in pregnant rats

Contact Info

Product

Resources

About