Role of Dynamic Contrast Enhanced Magnetic Resonance (Mr) Imaging and Proton MR Spectroscopic Imaging in the Detection of Local Recurrence After Radical Prostatectomy for Prostate Cancer

Sciarra, Alessandro; Panebianco, Valeria; Salciccia, Stefano; María, Ana; Gomez, Autran; Gentilucci, Alessandro; Gentile, Vincenzo

doi:10.1016/s0022-5347(08)61879-0

Cited by 117 publications

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“…Spectroscopy has been used to detect locally recurrent cancer after radiation therapy [27][28][29], cryotherapy [30] or radical prostatectomy [31]. However, spectroscopy specificity seems limited after radiation therapy [29] and its accuracy in detecting recurrences after radical prostatectomy remains controversial [32].…”

Section: Discussionmentioning

confidence: 99%

Prostate cancer transrectal HIFU ablation: detection of local recurrences using T2-weighted and dynamic contrast-enhanced MRI

et al. 2009

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The objective was to evaluate T2-weighted (T2w) and dynamic contrast-enhanced (DCE) MRI in detecting local cancer recurrences after prostate high-intensity focused ultrasound (HIFU) ablation. Fifty-nine patients with biochemical recurrence after prostate HIFU ablation underwent T2-weighted and DCE MRI before transrectal biopsy. For each patient, biopsies were performed by two operators: operator 1 (blinded to MR results) performed random and colour Doppler-guided biopsies ("routine biopsies"); operator 2 obtained up to three cores per suspicious lesion on MRI ("targeted biopsies"). Seventy-seven suspicious lesions were detected on DCE images (n = 52), T2w images (n = 2) or both (n = 23). Forty patients and 41 MR lesions were positive at biopsy. Of the 36 remaining MR lesions, 20 contained viable benign glands. Targeted biopsy detected more cancers than routine biopsy (36 versus 27 patients, p = 0.0523). The mean percentages of positive cores per patient and of tumour invasion of the cores were significantly higher for targeted biopsies (p < 0.0001). The odds ratios of the probability of finding viable cancer and viable prostate tissue (benign or malignant) at targeted versus routine biopsy were respectively 3.35 (95% CI 3.05-3.64) and 1.38 (95% CI 1.13-1.63). MRI combining T2-weighted and DCE images is a promising method for guiding post-HIFU biopsy towards areas containing recurrent cancer and viable prostate tissue.

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Section: Discussionmentioning

confidence: 99%

Prostate cancer transrectal HIFU ablation: detection of local recurrences using T2-weighted and dynamic contrast-enhanced MRI

et al. 2009

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“…Normales Prostatagewebe weist eine hohe Konzentration an Zitrat auf, während das Prostatakarzinom charakteristischerweise eine erhöhte Cholinkonzentration bei erniedrigter Zitratkonzentration zeigt, so dass insbesondere ein erhöhter Cholin-Zitrat-Quotient als Malignitätskriterium in der MRS verwendet wird. In aktuellen Studien zeigte sich eine Sensitivität von 77-84% im Nachweis des Prostatakarzinoms [17,25,30]. Allerdings scheint eine deutliche Abhängigkeit vom Malignitätsgrad zu bestehen: die Sensitivität der MRS betrug bei einem GleasonScore von 3+3 nur 44%, bei einem Score von 4+4 aber 89% [33].…”

Section: Mr-spektroskopieunclassified

Bedeutung der Magnetresonanztomographie (MRT) für Nachweis und Ausschluss des Prostatakarzinoms

Stattaus

Forsting

2010

Urologe

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This review illustrates the relevance of magnetic resonance imaging (MRI) for the detection or exclusion of prostate cancer. The functional MR methods dynamic contrast-enhanced MRI (DCE-MRI), MR spectroscopy, and diffusion-weighted imaging (DWI) helped in recent years to establish MRI as the imaging method of choice for prostate cancer. Indications for MRI of the prostate regarding recent guidelines and new concepts of cancer therapy are introduced.

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“…Other sites include the anterior and the posterior bladder neck and, less frequently, the retrovesical space (posterior to the bladder neck). Conversely, after RT, morphological changes in the prostate include inflammation, glandular atrophy, fibrosis, and shrinkage [5,6].A large number of studies have shown that magnetic resonance imaging (MRI) is a powerful tool for early detection of local recurrence after surgery [7][8][9][10][11][12] and CME activity This article has been selected as the CME activity for the current month. Please visit https://ce.mayo.edu/node/6231 and follow the instructions to complete this CME activity.…”

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confidence: 99%

“…A large number of studies have shown that magnetic resonance imaging (MRI) is a powerful tool for early detection of local recurrence after surgery [7][8][9][10][11][12] and CME activity This article has been selected as the CME activity for the current month. Please visit https://ce.mayo.edu/node/6231 and follow the instructions to complete this CME activity.…”

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confidence: 99%

“…A large number of studies have shown that magnetic resonance imaging (MRI) is a powerful tool for early detection of local recurrence after surgery [7][8][9][10][11][12] and external beam radiation therapy (EBRT) [13][14][15][16][17]. However, the introduction of Choline PET/CT, labeled with 11 C or 18 F, has deeply changed the management of patients with biochemical recurrence.…”

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confidence: 99%

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The ability of 18F-choline PET/CT to identify local recurrence of prostate cancer

Evangelista

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Hodolič³

et al. 2015

Abdom Imaging

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Role of Dynamic Contrast Enhanced Magnetic Resonance (Mr) Imaging and Proton MR Spectroscopic Imaging in the Detection of Local Recurrence After Radical Prostatectomy for Prostate Cancer

Cited by 117 publications

References 0 publications

Prostate cancer transrectal HIFU ablation: detection of local recurrences using T2-weighted and dynamic contrast-enhanced MRI

Prostate cancer transrectal HIFU ablation: detection of local recurrences using T2-weighted and dynamic contrast-enhanced MRI

Bedeutung der Magnetresonanztomographie (MRT) für Nachweis und Ausschluss des Prostatakarzinoms

The ability of 18F-choline PET/CT to identify local recurrence of prostate cancer

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