Role of dose order in the development of tolerance to effects of cocaine on schedule-controlled behavior in pigeons

Miller, Michelle L.; Branch, Marc N.

doi:10.1007/s00213-002-1085-3

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…Doses were delivered in the following descending order: 1.0, 0.3, 0.1, and 0.03 mg/kg nicotine and vehicle. There is no evidence that the order of dose delivery influences responding (Miller & Branch, 2002). If, after two complete cycles, the results for a particular dose were unreliable (i.e., increases relative to vehicle after one injection and decreases relative to vehicle after another injection, as noted by visual analysis), additional exposures of a given dose were delivered until two reliable effects were achieved.…”

Section: Methodsmentioning

confidence: 99%

Effects of acute and chronic nicotine on responses maintained by primary and conditioned reinforcers in rats.

Raiff

Dallery²

2006

Experimental and Clinical Psychopharmacology

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There is growing recognition that nonnicotine factors, such as the sensory stimuli associated with smoking, can play a critical role in the maintenance of cigarette smoking. However, little is known about the effects of nicotine on responding maintained by these stimuli, which are assumed to be conditioned reinforcers. The authors used an animal model to examine the acute and chronic effects of nicotine on responses maintained by food and conditioned reinforcers (i.e., lights) and responses in the absence of programmed consequences (i.e., extinction). During the acute phase, 4 male rats received 5 doses of subcutaneous nicotine. One dose of nicotine was then administered for a minimum of 60 days. Food-maintained and extinction responses did not significantly increase during the acute phase; however, food-maintained responses did increase during the chronic phase. Relative to vehicle, intermediate doses increased responses maintained by conditioned reinforcers during both phases. The results suggest that nicotine enhances responding maintained by conditioned reinforcers and possibly by food.

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Section: Methodsmentioning

confidence: 99%

Effects of acute and chronic nicotine on responses maintained by primary and conditioned reinforcers in rats.

Raiff

Dallery²

2006

Experimental and Clinical Psychopharmacology

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Interactions among unit-price, fixed-ratio value, and dosing regimen in determining effects of repeated cocaine administration

Yoon

Branch

2004

Behavioural Processes

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Tolerance to response-disruptive effects of cocaine is facilitated by opportunity to respond in the absence of drug

Miller

Branch

2004

Pharmacology Biochemistry and Behavior

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Role of dose order in the development of tolerance to effects of cocaine on schedule-controlled behavior in pigeons

Abstract: These results suggest that dose order under a variable-dosing regimen does not significantly affect the final attainment of tolerance, although it may contribute to the speed with which tolerance develops.

Cited by 4 publications

References 17 publications

Effects of acute and chronic nicotine on responses maintained by primary and conditioned reinforcers in rats.

Effects of acute and chronic nicotine on responses maintained by primary and conditioned reinforcers in rats.

Interactions among unit-price, fixed-ratio value, and dosing regimen in determining effects of repeated cocaine administration

Tolerance to response-disruptive effects of cocaine is facilitated by opportunity to respond in the absence of drug

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