Role of dopamine in distal retina

Popova, E.

doi:10.1007/s00359-014-0906-2

Cited by 54 publications

(59 citation statements)

References 243 publications

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“…The pathogenesis of PD involves the progressive degeneration of dopaminergic neurons and dopamine (DA) depletion in the nigrostriatal system. Dopaminergic neurons were identified in the neural retina as amacrine and interplexiform cells (Frederick et al, 1982) (Popova, 2014). Therefore, the distribution of one of the two enzymes involved in DA synthesis, tyrosine hydroxylase (TH), was also analyzed in both control and DJ-1 KO mice.…”

Section: Resultsmentioning

confidence: 99%

Loss of DJ-1 elicits retinal abnormalities, visual dysfunction, and increased oxidative stress in mice

Bonilha

Bell

Rayborn

et al. 2015

Experimental Eye Research

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DJ-1/PARK7 mutations or deletions cause autosomal recessive early onset Parkinson’s disease (PD). Thus, DJ-1 protein has been extensively studied in brain and neurons. PD patients display visual symptoms; however, the visual symptoms specifically attributed to PD patients carrying DJ-1/PARK7 mutations are not known. In this study, we analyzed the structure and physiology of retinas of 3- and 6-month-old DJ-1 knockout (KO) mice to determine how loss of function of DJ-1 specifically contributes to the phenotypes observed in PD patients. As compared to controls, the DJ-1 KO mice displayed an increase in the amplitude of the scotopic ERG b-wave and cone ERG, while the amplitude of a subset of the dc-ERG components were decreased. The main structural changes in the DJ-1 KO retinas were found in the outer plexiform layer (OPL), photoreceptors and retinal pigment epithelium (RPE), which were observed at 3 months and progressively increased at 6 months. RPE thinning and structural changes within the OPL were observed in the retinas in DJ-1 KO mice. DJ-1 KO retinas also exhibited disorganized outer segments, central decrease in red/green cone opsin staining, decreased labeling of ezrin, broader distribution of ribeye labeling, decreased tyrosine hydroxylase in dopaminergic neurons, and increased 7,8- dihydro-8-oxoguanine-labeled DNA oxidation. Accelerated outer retinal atrophy was observed in DJ-1 KO mice after selective oxidative damage induced by a single tail vein injection of NaIO3, exposing increased susceptibility to oxidative stress. Our data indicate that DJ-1-deficient retinas exhibit signs of morphological abnormalities and physiological dysfunction in association with increased oxidative stress. Degeneration of RPE cells in association with oxidative stress is a key hallmark of age-related macular degeneration (AMD). Therefore, in addition to detailing the visual defects that occur as a result of the absence of DJ-1, our data is also relevant to AMD pathogenesis.

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Section: Resultsmentioning

confidence: 99%

Loss of DJ-1 elicits retinal abnormalities, visual dysfunction, and increased oxidative stress in mice

Bonilha

Bell

Rayborn

et al. 2015

Experimental Eye Research

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“…However, it is worth noting that the visual signal processes must be altered in KO mice as dopamine plays an important and extensive modulatory role in the vertebrate visual system. 26,40 Reported and observed effects of D1Rs and D2Rs on the ERGs seem to be contradictory. Pharmacologic blockade or genetic mutation of D2Rs in this study slightly increased b-wave and summed OP amplitudes, which are similar to the effects mediated by D2R antagonists in goldfish 41 …”

Section: Discussionmentioning

confidence: 99%

“…25 Studies based on autoradiography and immunohistochemistry found that horizontal, bipolar, amacrine, and ganglion cells express mainly D1-like receptors, whereas photoreceptors express D2 receptors. 26 Similar to dopamine, the affinity of APO for D2 receptors (D2Rs) is up to 22-fold greater than for D1 receptors (D1Rs). 27 An important step in evaluating the involvement of dopamine signaling in refractive development and eye growth is to determine the specific type of dopamine receptors involved.…”

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confidence: 99%

Dopamine D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice

Huang

Zhang

Wang

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To determine the roles of dopamine D2 receptors (D2Rs) and dopamine D1 receptors (D1Rs) in the inhibition of form-deprivation myopia (FDM) by the nonselective dopamine agonist apomorphine (APO) in D2R-knockout (D2R-KO) and D1R-KO mice. METHODS.Retinal layer thicknesses and electroretinograms (ERGs) were analyzed in KO mice and in D2R and D1R antagonist-treated mice. D2R-KO or D1R-KO mice and wild-type (WT) littermates were subjected to form deprivation during postnatal weeks 5 to 8. Both groups were intraperitoneally injected daily with either APO (5 lg/g body weight) dissolved in 1 lg/ lL ascorbic acid or vehicle alone. Refraction, vitreous chamber depth (VCD), and axial length (AL), among other parameters, were measured prior to and at the end of the treatment period.RESULTS. The retinal layer thicknesses and ERGs in KO mice were similar to those treated with D2R and D1R antagonists. APO administration in WT mice inhibited the development of FDM by approximately 80%. FDM in D2R-KO mice was inhibited approximately 50% compared with WT mice and was further inhibited by APO to a level similar to that in APO-treated WT mice. FDM development in D1R-KO mice was similar to that in WT mice and was not affected by APO administration. The changes in VCD and AL were consistent with refraction data.CONCLUSIONS. In mice, APO-mediated FDM inhibition was abolished by D1R KO but not D2R KO. This indicates the specificity of D1Rs for the pharmacologic inhibitory effect of APO on FDM and a nonessential role of D2Rs in this process in mice.

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“…A number of factors control spinule formation including dopamine and protein kinase C (reviewed in Wagner and Djamgoz 1993; Popova 2014), as well as nerve growth factor (Haamedi et al 2001) and retinoic acid (Dirks et al 2004). Spinules may mediate “…feedback activity essential for the coding of antagonistic color information” (Popova 2014). Some believe that the spinules mediate a subset of postsynaptic responses, as they possess structures similar to PSDs.…”

Section: Synaptic/neuronal Invaginating Projections In More Complex Amentioning

confidence: 99%

Structure, Distribution, and Function of Neuronal/Synaptic Spinules and Related Invaginating Projections

et al. 2015

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Neurons and especially their synapses often project long thin processes that can invaginate neighboring neuronal or glial cells. These “invaginating projections” can occur in almost any combination of postsynaptic, presynaptic, and glial processes. Invaginating projections provide a precise mechanism for one neuron to communicate or exchange material exclusively at a highly localized site on another neuron, e.g., to regulate synaptic plasticity. The best-known types are postsynaptic projections called “spinules” that invaginate into presynaptic terminals. Spinules seem to be most prevalent at large very active synapses. Here, we present a comprehensive review of all kinds of invaginating projections associated with both neurons in general and more specifically with synapses; we describe them in all animals including simple, basal metazoans. These structures may have evolved into more elaborate structures in some higher animal groups exhibiting greater synaptic plasticity. In addition to classic spinules and filopodial invaginations, we describe a variety of lesser-known structures such as amphid microvilli, spinules in giant mossy terminals and en marron/brush synapses, the highly specialized fish retinal spinules, the trophospongium, capitate projections, and fly gnarls, as well as examples in which the entire presynaptic or postsynaptic process is invaginated. These various invaginating projections have evolved to modify the function of a particular synapse, or to channel an effect to one specific synapse or neuron, without affecting those nearby. We discuss how they function in membrane recycling, nourishment, and cell signaling and explore how they might change in aging and disease.

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Role of dopamine in distal retina

Cited by 54 publications

References 243 publications

Loss of DJ-1 elicits retinal abnormalities, visual dysfunction, and increased oxidative stress in mice

Loss of DJ-1 elicits retinal abnormalities, visual dysfunction, and increased oxidative stress in mice

Dopamine D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice

Structure, Distribution, and Function of Neuronal/Synaptic Spinules and Related Invaginating Projections

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