Role of dopamine D3 receptor in alleviating behavioural deficits in animal models of post-traumatic stress disorder

Song, Dake; Ge, Yaping; Chen, Zhaodi; Shang, Chao; Guo, Ying; Zhao, Tai-Yun; Li, Yunfeng; Wu, Ning; Song, Rui; Li, Jin

doi:10.1016/j.pnpbp.2018.03.001

Cited by 21 publications

(10 citation statements)

References 68 publications

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“…One possible explanation for these changes is dopaminergic modulation. Various disorders, such as addiction and post‐traumatic stress disorder, are associated with dysfunctional dopamine levels in response to sensory stimuli (Berke & Hyman, 2000; Di Chiara & Imperato, 1988; Duan et al, 2015; Ross & Peselow, 2009; Song et al, 2018). Evidence of dopaminergic modulation would open the doors of visual neuroscience, expanding the clinical relevance of dopamine and the SC.…”

Section: Discussionmentioning

confidence: 99%

Throwing open the doors of perception: The role of dopamine in visual processing

Woolrych

Vautrelle

Reynolds

et al. 2021

Eur J of Neuroscience

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Animals form associations between visual cues and behaviours. Although dopamine is known to be critical in many areas of the brain to bind sensory information with appropriate responses, dopamine's role in the visual system is less well understood. Visual signals, which indicate the likely occurrence of a rewarding or aversive stimulus or indicate the context within which such stimuli may arrive, modulate activity in the superior colliculus and alter behaviour. However, such signals primarily originate in cortical and basal ganglia circuits, and evidence of direct signalling from midbrain dopamine neurons to superior colliculus is lacking. Instead, hypothalamic A13 dopamine neurons innervate the superior colliculus, and dopamine receptors are differentially expressed in the superior colliculus, with D1 receptors in superficial layers and D2 receptors in deep layers. However, it remains unknown if A13 dopamine neurons control behaviours through their effect on afferents within the superior colliculus. We propose that A13 dopamine neurons may play a critical role in processing information in the superior colliculus, modifying behavioural responses to visual cues, and propose some testable hypotheses regarding dopamine's effect on visual perception.

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Section: Discussionmentioning

confidence: 99%

Throwing open the doors of perception: The role of dopamine in visual processing

Woolrych

Vautrelle

Reynolds

et al. 2021

Eur J of Neuroscience

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“…This suggests that interactions between endocannabinoid and dopaminergic signalling are involved in background contextual conditioning. D3 receptor knockouts subjected to contextual fear conditioning have been shown to express decreased freezing at retention test, compared to wild‐type controls, which did not involve differences in locomotor activity (Song et al., 2018). Taken together, these results suggest the involvement of D1 and D3 receptors in the acquisition, consolidation and/or retention of contextual fear.…”

Section: Dopamine Regulation Of the Acquisition Of Contextual Fearmentioning

confidence: 99%

Dopamine regulation of contextual fear and associated neural circuit function

Stubbendorff

Stevenson

2020

Eur J of Neuroscience

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Learning to associate certain contexts with threat and adapting to changing environmental contingencies by learning that such contexts are no longer associated with threat are both crucial for survival. Research over the last few decades has made considerable progress in determining the brain areas involved in the encoding, retrieval and extinction of contextual fear. These studies have identified the hippocampus and amygdala, along with the prefrontal cortex and other inter-connected brain areas, as key players in contextual fear processing. In contrast to the neural circuit basis of How to cite this article: Stubbendorff C, Stevenson CW. Dopamine regulation of contextual fear and associated neural circuit function.

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“…In a candidate gene study, the minor alleles of four DRD3 single nucleotide polymorphisms (rs2134655, rs201252087, rs4646996, and rs9868039) have been found to be protective against the risk for PTSD (Wolf et al, 2014). Preclinical findings have also demonstrated that the selective blockade of D3R ameliorates the PTSD-like behavior of rats, previously exposed to the single-prolonged stress model (Song et al, 2018). These observations indicate that the D3R may be considered an interesting pharmacological target for the development of new effective drugs for the treatment of PTSD.…”

Section: The Potential Therapeutic Value Of Targeting the Daergic Sysmentioning

confidence: 99%

Therapeutic Challenges of Post-traumatic Stress Disorder: Focus on the Dopaminergic System

et al. 2019

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Post-traumatic stress disorder (PTSD) is a mental illness developed by vulnerable individuals exposed to life-threatening events. The pharmacological unresponsiveness displayed by the vast majority of PTSD patients has raised considerable interest in understanding the poorly known pathophysiological mechanisms underlying this disorder. Most studies in the field focused, so far, on noradrenergic mechanisms, because of their well-established role in either tuning arousal or in encoding emotional memories. However, less attention has been paid to other neural systems. Manipulations of the dopaminergic system alter behavioral responses to stressful situations and recent findings suggest that dopaminergic dysfunction might play an overriding role in the pathophysiology of PTSD. In the present review, dopaminergic mechanisms relevant for the pathogenesis of PTSD, as well as potential dopaminergic-based pharmacotherapies are discussed in the context of addressing the unmet medical need for new and effective drugs for treatment of PTSD.

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Role of dopamine D3 receptor in alleviating behavioural deficits in animal models of post-traumatic stress disorder

Cited by 21 publications

References 68 publications

Throwing open the doors of perception: The role of dopamine in visual processing

Throwing open the doors of perception: The role of dopamine in visual processing

Dopamine regulation of contextual fear and associated neural circuit function

Therapeutic Challenges of Post-traumatic Stress Disorder: Focus on the Dopaminergic System

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