Role of DNA Repair Variants and Diagnostic Radiology Exams in Differentiated Thyroid Cancer Risk: A Pooled Analysis of Two Case–Control Studies

Zidane, Monia; Truong, Thérèse; Lesueur, Fabienne; Xhaard, Constance; Cordina‐Duverger, Emilie; Boland, Anne; Blanché, Hélène; Ory, Catherine; Chevillard, Sylvie; Deleuze, Jean‐François; Souchard, Vincent; Ren, Yan; Zemmache, Mohammed Zakarya; Canale, Sandra; Borson‐Chazot, Françoise; Schvartz, Claire; Barjoan, Eugènia Mariné; Guizard, Anne‐Valérie; Laurent‐Puig, Pierre; Mulot, Claire; Guibon, Julie; Karimi, Mojgan; Schlumberger, Martin; Adjadj, E; Rubino, Carole; Guénel, Pascal; Cazier, Jean‐Baptiste; Vathaire, Florent de

doi:10.1158/1055-9965.epi-20-1142

Cited by 3 publications

(2 citation statements)

References 52 publications

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“…Elevated IRRs for thyroid cancer were reported in Australian (IRR 1.40, 95% CI 1.23-1.59) ( 100 ) and Korean studies (IRR 2.19, 95% CI 1.97-2.44) ( 101 ). In a French study of thyroid cancers with mean thyroid dose of 2.79 mGy (0-194 mGy, range) from diagnostic radiology exposures that included conventional radiology examinations, CT scans, and nuclear medicine procedures, a statistically significant dose–response was found (OR at 1 mGy 1.00-1.02 in different models) in childhood exposures but not in adults ( 102 ). As estimated for the youngest children, the mean excess lifetime cancer risk per 10 000 chest scans (thyroid doses 27-20.3 mGy) varied from 11 to 35 cases in girls and from 2 to 6 cases in boys aged from 0 (newborns) to 10 years ( 103 ).…”

Section: Radiation Exposure and Risk For Thyroid Cancermentioning

confidence: 99%

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Radiation-Related Thyroid Cancer

Saenko

Mitsutake

2023

Endocrine Reviews

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Radiation is an environmental factor that elevates the risk of developing thyroid cancer. Actual and possible scenarios of exposures to external and internal radiation are multiple and diverse. This article reviews radiation doses to the thyroid and corresponding cancer risks due to planned, existing, and emergency exposure situations, and medical, public, and occupational categories of exposures. Any exposure scenario may deliver a range of doses to the thyroid, and the risk for cancer is addressed along with modifying factors. The consequences of the Chornobyl and Fukushima nuclear power plants accidents are described, summarizing the information on thyroid cancer epidemiology, treatment and prognosis, clinicopathological characteristics, and genetic alterations. The Chornobyl thyroid cancers evolve in time: becoming less aggressive and driver shifting from fusions to point mutations. A comparison of thyroid cancers from the two areas reveals numerous differences that cumulatively suggest the low probability of radiogenic nature of thyroid cancers in Fukushima. In view of continuing usage of different sources of radiation in various settings, the possible ways of reducing thyroid cancer risk from exposures are considered. For the external exposures, reasonable measures are generally in line with the “As Low As Reasonably Achievable” (ALARA) principle, while for the internal irradiation from radioiodine, thyroid blocking with stable iodine may be recommended in addition to other measures in case of anticipated exposures from a nuclear reactor accident. Finally, the perspectives of studies of radiation effects on the thyroid are discussed from the epidemiological, basic science, and clinical points of view.

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Section: Radiation Exposure and Risk For Thyroid Cancermentioning

confidence: 99%

“…Among the diagnostic radiology examination studies, only 1 reported very low but statistically significant dose–response (OR at 1 mGy 1.00-1.02) ( 102 ).…”

Section: Radiation Exposure and Risk For Thyroid Cancermentioning

confidence: 99%

Radiation-Related Thyroid Cancer

Saenko

Mitsutake

2023

Endocrine Reviews

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Review of the risk of cancer following low and moderate doses of sparsely ionising radiation received in early life in groups with individually estimated doses

Little

Wakeford

Bouffler³

et al. 2022

Environment International

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A Historical Survey of Key Epidemiological Studies of Ionizing Radiation Exposure

Little,

Bazyka,

de Gonzalez

et al. 2024

Radiation Research

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In this article we review the history of key epidemiological studies of populations exposed to ionizing radiation. We highlight historical and recent findings regarding radiation-associated risks for incidence and mortality of cancer and non-cancer outcomes with emphasis on study design and methods of exposure assessment and dose estimation along with brief consideration of sources of bias for a few of the more important studies. We examine the findings from the epidemiological studies of the Japanese atomic bomb survivors, persons exposed to radiation for diagnostic or therapeutic purposes, those exposed to environmental sources including Chornobyl and other reactor accidents, and occupationally exposed cohorts. We also summarize results of pooled studies. These summaries are necessarily brief, but we provide references to more detailed information. We discuss possible future directions of study, to include assessment of susceptible populations, and possible new populations, data sources, study designs and methods of analysis.

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Role of DNA Repair Variants and Diagnostic Radiology Exams in Differentiated Thyroid Cancer Risk: A Pooled Analysis of Two Case–Control Studies

Cited by 3 publications

References 52 publications

Radiation-Related Thyroid Cancer

Radiation-Related Thyroid Cancer

Review of the risk of cancer following low and moderate doses of sparsely ionising radiation received in early life in groups with individually estimated doses

A Historical Survey of Key Epidemiological Studies of Ionizing Radiation Exposure

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