Role of Distinct Fat Depots in Metabolic Regulation and Pathological Implications

Long-term physical inactivity induces significant changes in biochemical pathways related to metabolism of proteins and glycerophospholipids in mice

“…40,41 Physical activity is also suggested to modulate the secretion of many contraction-associated myokines. 18 One of these, myostatin accumulation, is another plausible cause for InR-induced skeletal muscle wasting and fat accumulation in mice. 42 In our study, an increased circulatory concentration of this in SED is associated with loss of muscle protein due to fat storage.…”

“…Secretion of these during or after exercise depends on the duration of activity and the site of secretion to play inflammatory and anti-inflammatory roles. [17][18][19] These changes in metabolism are closely associated with the molecular adaptation of organs to the molecules in the systemic circulation (energysensing metabolites and cytokines).…”

Lactobacillus rhamnosus 069 and Lactobacillus brevis 031: Unraveling Strain-Specific Pathways for Modulating Lipid Metabolism and Attenuating High-Fat-Diet-Induced Obesity in Mice

“…Consequently, it has emerged as a major public health concern . White adipose tissue (WAT), the primary fat-storing depot and the largest endocrine organ, releases adipokines and cytokines systemically, contributing to chronic low-grade inflammation, termed metaflammation, and altered metabolism . Leptin, elevated in obesity, plays a crucial role in regulating the inflammatory response, influencing development, proliferation, maturation, and activation.…”

The crosstalk between BAT thermogenesis and skeletal muscle dysfunction

“…Recent studies have shown that myocytes and brown adipocytes are both derived from mesenchymal stem cells and share similar precursor transcriptomes (Bal et al, 2016;Bal et al, 2017;Scheele and Wolfrum, 2020;Pan and Chen, 2021;Sahu et al, 2023), and both BAT and skeletal muscle use energy substrates including fat and glucose, as fuel to generate heat (Pani et al, 2022). From a metabolic perspective, the thermogenesis of BAT and skeletal muscle is in a dynamic balance.…”