Role of diffusion weighted MRI in the differential diagnosis of endometrial cancer, polyp, hyperplasia, and physiological thickening

Bakir, Barış; Şanlı, Şükrü; Bakir, Vuslat Lale; Ayas, Selçuk; Yıldız, Sevda; İyibozkurt, Ahmet Cem; Kartal, Merve Gülbiz; Yavuz, Ekrem

doi:10.1016/j.clinimag.2016.10.016

Cited by 43 publications

(27 citation statements)

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“…The most common presenting complaint of the patients in our study was abnormal uterine bleeding followed by discharge PV, followed by pelvic pain. This is in accordance with the study of Bakir B 2017 [6] On TVS out of 65 cases 34 cases (52%) had heterogenous echotexture and 31 cases (48%) had homogenous echotexture. Lesions with heterogenous echotexture were suspicious for non benign and inflammatory causes.…”

Section: Discussionsupporting

confidence: 92%

TO SEPARATELY ASSESS THE DIAGNOSTIC POTENTIAL OF TVS & MRI IN THE TERMS OF SENSITIVITY AND SPECIFICITY BY CORRELATING THE IMAGING FINDINGS WITH HISTOPATHOLOGY

Mathur

2020

IJMBS

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This prospective study was done in the Department of Radio diagnosis Govt. Medical College, Kozhikode. A total of 65 patients who were referred to our department with clinical suspicion of endometrial lesions and incidentally detected endometrial lesions on ultrasonography underwent transvaginal ultrasound and subsequent Imaging evaluation of pelvis MRI has very high sensitivity (95%) and specificity (98%) and is almost as accurate (97%) as histopathology in differentiating benign from malignant lesions. Addition of DWI with ADC mapping to conventional MRI increases its accuracy even more. However there is inherent limitation to MRI in detecting carcinoma in situ and micrometastasis. Keywords: TVS, MRI, Sensitivity, Specificity, Histopathology.

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Section: Discussionsupporting

confidence: 92%

TO SEPARATELY ASSESS THE DIAGNOSTIC POTENTIAL OF TVS & MRI IN THE TERMS OF SENSITIVITY AND SPECIFICITY BY CORRELATING THE IMAGING FINDINGS WITH HISTOPATHOLOGY

Mathur

2020

IJMBS

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“…The increased cellularity of endometrial cancer causes restricted diffusion, which leads to increased signal on the DW image and a reduced ADC value [ 25 ]. Compared with T1WI-DCE, SS-EPI DWI shows great accuracy, sensitivity and specificity in diagnosing myometrial invasion of endometrial carcinoma [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

High resolution diffusion-weighted imaging with readout segmentation of long variable echo-trains for determining myometrial invasion in endometrial carcinoma

et al. 2020

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Background We assessed the image quality of endometrial cancer lesions by readout segmentation of long variable echo-trains (RESOLVE) diffusion-weighted imaging (DWI) compared with that by single-shot echo-planar imaging (SS-EPI) DWI, aimed to explore the value of RESOLVE DWI for determining myometrial invasion and clinical stage in endometrial cancer. Materials and methods From April 2017 to March 2018, a total of 30 endometrial cancer patients (mean age 52.8 ± 9.0 years), who had undergone RESOLVE DWI and SS-EPI DWI, were included in the study. The image quality of endometrial carcinoma by two kinds of DWI scanning methods was compared qualitatively and quantitatively. The Spearman rank correlation test was used to assess the correlation of qualitative image quality scores between two readers. The accuracy of two DWI methods in detecting myometrial invasion and staging of endometrial carcinoma was calculated according to postoperative pathological results. The indexes were analyzed including sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV). Results The qualitative score of RESOLVE DWI group was superior to SS-EPI DWI group in every aspect of five aspects (all P < 0.001). Interobserver agreement of depiction was good or excellent in two DWI sequences. Signal to noise ratio and contrast to noise ratio values in RESOLVE DWI group were both higher than those in SS-EPI DWI group (P<0.001). No statistical difference of apparent diffusion coefficient value was observed between two DWI groups (P = 0.261). The specificity, accuracy, PPV, and NPV of estimating myometrial invasion by RESOLVE DWI in three cases (intramucosal lesion, <50% superficial invasion and ≥ 50% deep invasion) were all higher than those by SS-EPI DWI for endometrial carcinoma. Especially RESOLVE DWI was valuable in judging <50% superficial invasion (95%CI:0.586, 0.970). No significant difference in accuracy staging was between the two DWI groups (P = 0.125). Conclusion RESOLVE DWI can provide higher quality images of endometrial carcinoma than SS-EPI DWI. The high-quality images are helpful for precise assessment of myometrial invasion in endometrial cancer.

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“…4 In abdominal organs, DWI has been shown to be useful for the detection and differential diagnosis of focal lesions of the liver, 5 kidney, 6 pancreas, 7 prostate, 8 and uterus. 9 Diffusion-weighted imaging in oncological imaging is based on the higher cellularity of cancer tissue in comparison to healthy neighboring tissue and consequently the higher diffusion restriction of water movement by cellular membranes. 10 It has also been shown that DWI is capable to characterize and stage liver fibrosis with increasing diffusion restriction for more severe stages.…”

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confidence: 99%

Intravoxel Incoherent Motion Analysis of Abdominal Organs

et al. 2018

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Role of diffusion weighted MRI in the differential diagnosis of endometrial cancer, polyp, hyperplasia, and physiological thickening

Cited by 43 publications

References 20 publications

TO SEPARATELY ASSESS THE DIAGNOSTIC POTENTIAL OF TVS & MRI IN THE TERMS OF SENSITIVITY AND SPECIFICITY BY CORRELATING THE IMAGING FINDINGS WITH HISTOPATHOLOGY

TO SEPARATELY ASSESS THE DIAGNOSTIC POTENTIAL OF TVS & MRI IN THE TERMS OF SENSITIVITY AND SPECIFICITY BY CORRELATING THE IMAGING FINDINGS WITH HISTOPATHOLOGY

High resolution diffusion-weighted imaging with readout segmentation of long variable echo-trains for determining myometrial invasion in endometrial carcinoma

Intravoxel Incoherent Motion Analysis of Abdominal Organs

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