Role of diffusion-weighted magnetic resonance imaging for predicting of tumor invasiveness for clinical stage IA non-small cell lung cancer☆

Kanauchi, Naoki; Oizumi, Hiroyuki; Honma, Tsuguo; Kato, Hirohisa; Endo, Masatoshi; Suzuki, Jun; Fukaya, Ken; Sadahiro, Mitsuaki

doi:10.1016/j.ejcts.2008.12.039

Cited by 44 publications

(33 citation statements)

References 19 publications

(40 reference statements)

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“…Kanauchi et al (52), to assess the role of DWI for predicting tumor invasiveness, investigated 41 patients with clinical stage IA NSCLC who underwent both 18 F-FDG PET/CT and DWI. A previous study had already shown that the maximum SUV (SUV max ) is an independent predictor of disease-free survival in NSCLC (58).…”

Section: Pulmonary Lesions and Lung Cancermentioning

confidence: 99%

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Kwee¹,

Takahara²,

Ochiai³

et al. 2010

J Nucl Med

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18 F-FDG PET is an established functional imaging modality for the evaluation of human disease. Diffusion-weighted MRI (DWI) is another rapidly evolving functional imaging modality that can be used to evaluate oncologic and nononcologic lesions throughout the body. The information provided by 18 F-FDG PET and DWI can be complementary, because the 2 methods are based on completely different biophysical underpinnings. This article will describe the basic principles, clinical applications, and limitations of DWI. In addition, the available evidence that correlates and compares 18 F-FDG PET and DWI will be reviewed. PET,usi ng the radiotracer 18 F-FDG, is an established functional imaging modality for a variety of oncologic and nononcologic (e.g., inflammatory and infectious) applications (1-3). The contribution of 18 F-FDG PET to medicine has been unmatched by any other functional imaging modality (4). At present, there is also growing interest in the application of diffusion-weighted MRI (DWI) in the body (5-7). DWI allows visualization and quantification of the mobility of water molecules and has many potential clinical applications. Importantly, although 18 F-FDG PET and DWI are both functional imaging modalities and provide a high lesion-to-background contrast, they are based on completely different biophysical and biochemical underpinnings. Therefore, the information provided by the 2 imaging modalities may be regarded as complementary. Given the developing applications of DWI, the increasing use of multimodality imaging (8), and the expected advent of fully integrated PET/MRI systems (9), knowledge of the characteristics, possibilities, and limitations of DWI technique is becoming increasingly important. This is true for both the imaging specialists and the clinicians who use these modalities. This article will review the basic principles, clinical applications, and limitations of DWI. Furthermore, the available evidence that correlates and compares 18 F-FDG PET with DWI will be reviewed.

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Section: Pulmonary Lesions and Lung Cancermentioning

confidence: 99%

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Kwee¹,

Takahara²,

Ochiai³

et al. 2010

J Nucl Med

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“…The STIR approach has been most commonly used for fat suppression to achieve a more accurate ADC estimation. Early studies employed free breathing or breath holding (24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35). The latter type of study can be completed in two or more separate breathholding scans.…”

Section: Thoracic Applicationsmentioning

confidence: 99%

“…In qualitative evaluations, the chest wall muscles or spinal cord can be used as a standard of reference when evaluating the signal intensity of a target lesion (24,27,28,36). Malignant lesions tend to be hyperintense relative to the chest wall muscles or spinal cord.…”

Section: Thoracic Applicationsmentioning

confidence: 99%

“…However, they reported 83% sensitivity and 74% specificity using a threshold ADC value of 1.4×10 -3 mm 2 /s. Kanauchi et al (24) investigated tumor invasiveness with qualitative DWI in 41 patients with stage IA non-small cell lung carcinoma using lesion-to-spinal-cord ratios (LSR). It was reported that DWI was an independent predictive factor for tumor aggressiveness.…”

Section: Thoracic Applicationsmentioning

confidence: 99%

“…In heterogeneous tumors, care should be taken to place the ROI in the solid portion of the mass, excluding cystic or necrotic areas. DWI has been used to characterize lung lesions (27), to detect and classify adenocarcinomas (37), to predict tumor invasiveness in early-stage lung cancer (24), to detect tumors in collapsed lungs (32,33), and for nodal staging of lung cancer (26,35).…”

Section: Thoracic Applicationsmentioning

confidence: 99%

See 2 more Smart Citations

Diffusion weighted MRI for detecting and monitoring cancer: a review of current applications in body imaging

Türkbey

Aras

Karabulut

et al. 2011

Diagn Interv Radiol

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Imaging is used to detect, characterize, and monitor cancer. Recently, diffusion-weighted magnetic resonance imaging (DWI) has become a useful adjunct for assessing tumors with magnetic resonance imaging (MRI). DWI involves the acquisition of a magnetic resonance signal related to random thermal motion (Brownian motion) or the "diffusion" of water protons in tissue. The signal obtained with DWI is a measure of the net displacement of water molecules, e.g., the water path length in the extracellular, intracellular and intravascular spaces. This motion is largely random and can be reduced by structural barriers, such as cell membranes and collagen. Restricted diffusion in biological tissues is inversely proportional to tissue cellularity and the integrity of cell membranes, and it can be quantified with apparent diffusion coefficient (ADC) measurements (1). Depending on the microarchitecture, either restricted or increased diffusion can occur in malignant tumors. For instance, diffusion is restricted in cellular portions of the tumor, but it may be increased in necrotic portions (2, 3). Other causes of enhanced diffusion include increased water content arising from intratumoral edema and cystic tumor components (4-6).Although initially used to evaluate neurological diseases, the applications of DWI have been extended to oncologic imaging throughout the body made possible by improvements in MRI hardware and new sequences. The use of DWI as a complement to conventional MRI methods has led to improvements in the detection and characterization of tumors, treatment response monitoring, and detection of recurrence in oncology patients. Basic concepts of DWIIn 1965, Stejskal and Tanner (7) proposed the application of a symmetric pair of additional gradients on either side of the 180˚ refocusing radiofrequency pulse. The Stejskal-Tanner sequence is still the basis of modern DWI. For static water molecules, the phasing effect caused by the first gradient will be reversed by the second gradient, leading to no signal loss; however, this phasing effect will not be completely reversed if the water molecules are not stationary, which results in the observed well-known diffusion signal decay. The amount of diffusion weighting is determined by the b value, which describes the amplitude, duration of the applied gradient, and time interval between the two diffusion gradients (4). The degree of signal attenuation from water molecules is cor- ABSTRACT Diffusion-weighted magnetic resonance imaging (MRI), which involves the acquisition of a magnetic resonance signal related to the Brownian motion of water protons in tissue, has become a useful technique for assessing tumors. In this article, we review the basic concepts, imaging strategies, and body applications of diffusion-weighted MRI in detecting and monitoring cancer.

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Chest

Altun¹,

Busireddy²,

Birchard³

et al. 2015

Abdominal‐Pelvic MRI

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Role of diffusion-weighted magnetic resonance imaging for predicting of tumor invasiveness for clinical stage IA non-small cell lung cancer☆

Abstract: Our results suggest that DWI might be a useful method for predicting tumor invasiveness for clinical stage IA NSCLC.

Cited by 44 publications

References 19 publications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Diffusion weighted MRI for detecting and monitoring cancer: a review of current applications in body imaging

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Role of diffusion-weighted magnetic resonance imaging for predicting of tumor invasiveness for clinical stage IA non-small cell lung cancer☆

Abstract: Our results suggest that DWI might be a useful method for predicting tumor invasiveness for clinical stage IA NSCLC.

Cited by 44 publications

References 19 publications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and18F-FDG PET: The State of the Art and Potential Applications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and18F-FDG PET: The State of the Art and Potential Applications

Diffusion weighted MRI for detecting and monitoring cancer: a review of current applications in body imaging

Chest

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Product

Resources

About

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications