Role of Diffusion-Weighted Magnetic Resonance Imaging in the Evaluation of Ovarian Tumours

Jayasankaran, Sandya Chirukandath; Chelakkot, Prameela G.; Prabhakaran, Prabash; Sekhar, Resmi

doi:10.1007/s40944-019-0305-2

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“…Even normal ovaries may exhibit restricted diffusion, and thus, image interpretation in conjunction with the results of other image sequences is essential. The probable cutoff value of the ADC value to differentiate between malignant and benign adnexal masses was reported to be 1.13 × 10 −3 mm 2 /s in previous literature [25,26] and 1.27 × 10 −3 mm 2 /s in our study. However, the ADC values of two teratomas (0.54 × 10 −3 mm 2 /s and 0.99 × 10 −3 mm 2 /s, respectively) were lower than these cutoff values and were found to be lower than those of malignant masses in our study; these results are comparable with those of Kim et al [22], which might explain the high sensitivity but low specificity of using ADC cutoff values alone as an indicator of malignancy.…”

Section: Discussionsupporting

confidence: 58%

Magnetic Resonance Spectroscopy for Risk Stratification of Sonographically Indeterminate Ovarian Neoplasms: Preliminary Study

et al. 2021

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We aim to assess the additional value of diffusion-weighted imaging (DWI) and magnetic resonance spectroscopy (MRS) for the risk stratification of sonographically indeterminate ovarian neoplasms. A total of 21 patients with diagnosed adnexal masses between 2014 and 2017 were divided into malignant (four serous cystadenocarcinomas, four endometrioid carcinomas, three clear cell carcinomas, and one carcinosarcoma) and benign (four cystadenomas, two teratomas, one fibroma, one endometrioma, and one corpus luteal cyst) groups. An apparent diffusion coefficient (ADC) value of 1.27 × 10−3 mm2/s was considered as the optimal threshold in distinguishing malignant from benign ovarian tumors (sensitivity and specificity: 100% and 77.8%, respectively). Choline peaks were detected in six of seven O-RADS (Ovarian-Adnexal Imaging-Reporting Data System) 4 lesions and corrected all of the DWI false-negative clear cell carcinoma. Based on the presence of the choline peaks, the diagnostic performance of MRS showed a sensitivity of 77.8%, a specificity of 100%, and an accuracy of 85.7%, respectively. In conclusion, MRS could potentially play a complementary role for DWI in tumor characterization, particularly for O-RADS 4 tumors or clear cell carcinomas.

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Section: Discussionsupporting

confidence: 58%