1998
DOI: 10.1002/(sici)1097-0177(199804)211:4<382::aid-aja9>3.0.co;2-d
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Role of differential cell proliferation in the tail bud in aberrant mouse neurulation

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Cited by 18 publications
(6 citation statements)
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“…Finally, we describe clusters of neurons within the Fz3 Ϫ/Ϫ spinal cord that likely arise from errors in cell migration during neural tube closure, an hypothesis consistent with the curled tail phenotype seen in all Fz3 Ϫ/Ϫ embryos [an indication of an early neural tube defect (Peeters et al, 1998)] and our previous finding that several percentage of Fz3 Ϫ/Ϫ embryos exhibit an incompletely closed neural tube (Wang et al, 2002).…”
Section: Tract Anomaly In the Fz3supporting
confidence: 75%
“…Finally, we describe clusters of neurons within the Fz3 Ϫ/Ϫ spinal cord that likely arise from errors in cell migration during neural tube closure, an hypothesis consistent with the curled tail phenotype seen in all Fz3 Ϫ/Ϫ embryos [an indication of an early neural tube defect (Peeters et al, 1998)] and our previous finding that several percentage of Fz3 Ϫ/Ϫ embryos exhibit an incompletely closed neural tube (Wang et al, 2002).…”
Section: Tract Anomaly In the Fz3supporting
confidence: 75%
“…Hyperaccumulation of cells within the neuroectoderm lineage at the posterior of the Shp2 chimeric embryos caused the process of neural fold closure to occur aberrantly. This is potentially caused by the excessive numbers of cells within the neural folds, which could lead to enhanced ventral curvature of the body axis and likely inhibits fusion of the neural folds (33,34), thus resulting in spina bifida. Secondary neural tubes are another possible result of too many cells adopting the neural cell fate (18,35).…”
Section: Discussionmentioning
confidence: 99%
“…Neural tube closure defects are often associated with posterior truncations, and it has been postulated that the curvature of the body axis generated during tail bud outgrowth provides tension in the neural folds that facilitates closure (Copp et al, 1982;Copp, 1985;Gofflot et al, 1997;Peeters et al, 1998;Finnell et al, 2003). Over 80% of Fgfr1 ⌬Frs/⌬Frs embryos exhibit posterior truncations of varying severity (Fig.…”
Section: Fgfr1-frs Signaling Is Essential During Neurulation and Tailmentioning
confidence: 99%