Role of Different Subpopulations of CD8+ T Cells during HIV Exposure and Infection

González, Sandra; Taborda, Natalia A.; Rugeles, Marı́a Teresa

doi:10.3389/fimmu.2017.00936

Cited by 42 publications

(57 citation statements)

References 117 publications

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“…However, compared with CD3 + CD20 – T cells, the expression of CD38 was decreased significantly on CD3 + CD20 + T cells. Although CD38 was also considered as one of the activation markers on T cells , studies on infectious diseases showed definitively that a subset of human T cells expressing HLA‐DR but not CD38 have a particularly high ability to suppress the virus . Given the increased expression of HLA‐DR on CD3 + CD20 + T cells, it was reasonable to assume that CD3 + CD20 + T cells represented an activated subpopulation and had a potential effector function in patients with psoriasis.…”

Section: Discussionmentioning

confidence: 99%

“…showed definitively that a subset of human T cells expressing HLA-DR but not CD38 have a particularly high ability to suppress the virus [21,22]. Given the increased expression of HLA-DR on CD3 1 CD20 1 T cells, it was reasonable to assume that CD3 1 CD20 1 T cells represented an activated subpopulation and had a potential effector function in patients with psoriasis.…”

Section: Discussionmentioning

confidence: 99%

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Dissection of a circulating CD3+CD20+ T cell subpopulation in patients with psoriasis

Niu

Zhai

Fei

et al. 2018

Clinical and Experimental Immunology

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CD3 CD20 T cells are a population of CD3 T cells that express CD20 and identified in healthy donors and autoimmune diseases. However, the nature and role of these cells in patients with psoriasis remain unclear. In this study, we aimed to investigate the level, phenotype, functional and clinical relevance of CD3 CD20 T cells in the peripheral blood of patients with psoriasis. We found that a small subset of CD3 T cells expressed CD20 molecule in the peripheral blood of patients with psoriasis, and their levels were similar to those in healthy donors. Circulating CD3 CD20 T cells in patients with psoriasis were enriched in CD4 cells and displayed an activated effector phenotype, as these cells contained fewer CD45RA -naive and CCR7 cells with increased activity than those of CD3 T cells lacking CD20. In addition, compared with healthy donors, circulating CD3 CD20 T cells in patients with psoriasis produced more cytokines, interleukin (IL)-17A, tumour necrosis factor (TNF)-α and IL-21, but not IL-4 and IFN-γ. Furthermore, a significantly positive correlation was found between the levels of IL-17A, TNF-α and IL-21-production CD3 CD20 T cells with Psoriasis Area and Severity Index scores. Our findings suggest that CD3 CD20 T cells may play a role in the pathogenesis of psoriasis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Dissection of a circulating CD3+CD20+ T cell subpopulation in patients with psoriasis

Niu

Zhai

Fei

et al. 2018

Clinical and Experimental Immunology

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“…During acute viral infections, CD8+ T lymphocytes are able to control viral replication by producing cytokines and cytotoxic mediators 3,5 . However, when the infection becomes chronic, a persistent antigen exposure leads to the up-regulation of inhibitory receptors 3,5,12 . Also, at least in certain circumstances, it has been shown that the presence of inhibitory receptors may identify antigen specific chronically stimulated cells 16,17 .…”

Section: Polyfunctional Hiv-1 Specific Response By Cd8+ T Lymphocytesmentioning

confidence: 99%

Polyfunctional HIV-1 specific response by CD8+ T lymphocytes expressing high levels of CD300a

Vitallé

Terrén

Gamboa-Urquijo

et al. 2020

Sci Rep

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CD300a receptor is found on different CD8+ T cell subsets and its expression has been associated to a more cytotoxic molecular signature. CD300a has an important role in some viral infections and its expression levels are known to be modulated by human immunodeficiency virus (HIV)−1 infection on several cell types. The main objective of this work was to investigate CD300a expression and its regulation during HIV-1 specific CD8+ T cell responses. CD300a receptor expression was analysed by multiparametric flow cytometry on CD8+ T lymphocytes from HIV negative donors, naive HIV-1+ individuals and HIV-1+ subjects under suppressive combined antiretroviral therapy (cART). HIV-1 specific CD8+ T cell response was studied by stimulating cells with HIV-1 derived peptides or with a GagHIV-1 peptide. Our results showed that HIV-1 specific CD8+ T cells expressing higher levels of CD300a were more polyfunctional showing an increased degranulation and cytokine production. Moreover, we observed an up-regulation of CD300a expression after Gag HIV-1 peptide stimulation. Finally, our results demonstrated an inverse correlation between CD300a expression on CD8+ T lymphocytes and HIV disease progression markers. In conclusion, CD300a expression is associated to a better and more polyfunctional HIV-1 specific CD8+ T cell response. CD8+ T cells are very important effectors in the control and clearance of viruses through several mechanisms, including granule exocytosis and cytokine production 1-3 . Many reports have shown that CD8+ T cells play a very important role in the control of viral replication during the acute phase of human immunodeficiency virus (HIV)−1 infection, contributing to the initial control of infection 1,3-7 . Thus, a large number of current studies are focused on the search of new therapies with the aim of inducing a potent and effective HIV specific CD8+ T cell response [8][9][10] .After antigen recognition and subsequent activation, CD8+ T cells up-regulate the expression of inhibitory receptors with the aim of preventing an excessive response that, if not properly regulated, could be harmful to the host 11,12 . During chronic stimulation, as for example persistent exposure to HIV antigens, CD8+ T cells became progressively dysfunctional and exhausted, and the expression of inhibitory receptors persists 13 . Exhaustion is a process characterized by a loss of proliferative capacity, differentiation and effector functions 12,14,15 . There are several inhibitory receptors that are expressed on exhausted T cells. For instance, programed cell death-1 (PD1) is known to be involved in the regulation of CD8+ T lymphocytes function during chronic HIV-1 infection and their expression correlates with disease progression 11,12,15 . In addition to the negative regulatory role of these inhibitory receptors, they also mark antigen specific T cells. For example, it has been described that PD1 on CD8+ T cells identifies the repertoire of clonally expanded tumor-reactive lymphocytes and situations of chronic inflammation, which is ...

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“…It has been reported that the T CM cells of central long-term memory CD8 + T cells are derived from a subset of T EM cells, but the mechanism of this transformation is unclear 44,45 . Herein, we used vMIP-II studies to clearly demonstrate that the chemokine receptor-related phosphorylation pathway of effector CD8 + T cells is signi cantly down-regulated (but CCR7 pathway activation is still retained), and while inhibiting the apoptotic pathway, these molecular mechanisms affect the fate of effector CD8 + T cells, thereby increasing levels of central memory CD8 + T cells.…”

Section: Discussionmentioning

confidence: 99%

Chemokine Receptor Inhibitor vMIP-II Promoting Lymphocytes in COVID-19 Patients and Its Related Mechanism In Vitro

Li¹,

Wang²,

Feng

et al. 2020

Preprint

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Coronavirus disease (COVID-19) accompanies severe immune injury as well as a decrease and overactivation of T lymphocytes. We observed that vMIP-Ⅱ, a broad-spectrum chemokine receptor inhibitor, could improve the lymphocyte decrease of COVID-19. Comparisons of T cell populations in PBMCs showed that the effects of vMIP-II on the subsets of T cells and cytokine secretion stimulated by SARS-CoV-2 S protein were the same as those in the asymptomatic infection group: the proportion of CD8+TCM cells in the vMIP-II treatment and asymptomatic groups was significantly higher than that in the symptomatic control group. Differential gene expression of effector CD8+ T cells suggested that vMIP-II inhibits multiple chemokine receptors and related signal pathway and strengthens their stem proliferating capacity. Thus, vMIP-II reconstitutes cellular immunity lost due to acute infection of SARS-CoV-2 by modulating effector CD8+ T cells to produce more TCM cells.

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Role of Different Subpopulations of CD8+ T Cells during HIV Exposure and Infection

Cited by 42 publications

References 117 publications

Dissection of a circulating CD3+CD20+ T cell subpopulation in patients with psoriasis

Dissection of a circulating CD3+CD20+ T cell subpopulation in patients with psoriasis

Polyfunctional HIV-1 specific response by CD8+ T lymphocytes expressing high levels of CD300a

Chemokine Receptor Inhibitor vMIP-II Promoting Lymphocytes in COVID-19 Patients and Its Related Mechanism In Vitro

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