Role of dietary α- and γ-tocopherol from Rosa mosqueta oil in the prevention of alterations induced by high-fat diet in a murine model

Tapia, Gladys; Schwartz, David A.; Romero, Nalda; Pettinelli, Paulina; Dossi, Camila G.; Miguel, Manuel de; Gonzalez‐Mañán, Daniel

doi:10.1016/j.nut.2018.01.012

Cited by 7 publications

(4 citation statements)

References 42 publications

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“…Different forms of vitamin E or their long-chain metabolites can interfere with ROS production, NF-kB priming, or NLRP3 activation. Recently, further studies confirmed these results in two different murine models of HFD and alloxan-induced diabetes, especially regarding γ-tocopherol supplementation, as such, or in more complex extracts (e.g., Rosa mosqueta oil contains about 74 g/100 g oil of α-tocopherol and 359 g/100 g oil of γ-tocopherol, stripped corn oil) [ 176 , 177 ].…”

Section: Food Components As Nlpr3 Modulatorsmentioning

confidence: 81%

Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation

et al. 2022

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Inflammasomes are key intracellular multimeric proteins able to initiate the cellular inflammatory signaling pathway. NLRP3 inflammasome represents one of the main protein complexes involved in the development of inflammatory events, and its activity has been largely demonstrated to be connected with inflammatory or autoinflammatory disorders, including diabetes, gouty arthritis, liver fibrosis, Alzheimer’s disease, respiratory syndromes, atherosclerosis, and cancer initiation. In recent years, it has been demonstrated how dietary intake and nutritional status represent important environmental elements that can modulate metabolic inflammation, since food matrices are an important source of several bioactive compounds. In this review, an updated status of knowledge regarding food bioactive compounds as NLRP3 inflammasome modulators is discussed. Several chemical classes, namely polyphenols, organosulfurs, terpenes, fatty acids, proteins, amino acids, saponins, sterols, polysaccharides, carotenoids, vitamins, and probiotics, have been shown to possess NLRP3 inflammasome-modulating activity through in vitro and in vivo assays, mainly demonstrating an anti-NLRP3 inflammasome activity. Plant foods are particularly rich in important bioactive compounds, each of them can have different effects on the pathway of inflammatory response, confirming the importance of the nutritional pattern (food model) as a whole rather than any single nutrient or functional compound.

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Section: Food Components As Nlpr3 Modulatorsmentioning

confidence: 81%

Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation

et al. 2022

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“…Phytosterols are important bioactive constituents in grain oil and their consumption could reduce plasma cholesterol levels (Feng et al ., 2015; Kumar & Krishna, 2015). Tocopherols and pigments also have positive effects on lipid metabolism (Qiu et al ., 2015; Tapia et al ., 2018). It indicated that the refining processing causes the partial loss of the health benefits of millet bran oil due to decrease of bioactive components.…”

Section: Resultsmentioning

confidence: 99%

Crude and refined millet bran oil alleviate lipid metabolism disorders, oxidative stress and affect the gut microbiota composition in high‐fat diet‐induced mice

Yin

Yousaf

et al. 2021

Int J of Food Sci Tech

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To investigate crude millet bran oil (MBO) and refined millet bran oil (MRO) consumption on lipid metabolism in obese mice, C57BL/6 mice were fed with HFD/MBO and MRO (2 g kg À1 bw per day) for 12 weeks. Both MBO and MRO supplementation effectively alleviated hepatic lipid accumulation, which was associated with downregulation of the expression levels of acetyl-CoA carboxylase (Acaca), fatty acid synthase (Fasn), perilipin-2 (Plin2) and stearoyl-CoA desaturase (Scd). Only MBO supplementation significantly decreased plasma levels of total cholesterol (TC), catalase (CAT), hepatic lipid peroxidation and hepatic oxidative stress. It also increased the abundance of Akkermansia. The refining process caused a reduction of bioactive components (phytosterols, tocopherols and pigments) and a decrease in associated health benefits of MBO. Therefore, MBO can be moderately refined and still retain some health benefits, but new refining methods are needed to enhance the content of active compounds and improve the physiological efficacy of MRO.

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“…Trolox/L) compared to those having polyphenol levels of 116 or 407 mg/kg and antioxidant capacities of 3378 or 4841 μ mol eq. Trolox/L, respectively [ 34 ], and (ii) a regular rosa mosqueta oil (RMO) containing α - and γ -tocopherols compared to a RMO type devoid of tocopherols [ 44 ], findings that establish a threshold for the content of antioxidant components of natural products to achieve beneficial effects. In addition to the antioxidant effect of natural products in fatty liver, reduction of HFD-induced liver steatosis by EPA, HT, and EPA + HT supplementation may result from a direct activation of hepatic lipases such as patatin-like phospholipase domain-containing protein 3 (PNPLA3) which hydrolyses acylglycerols including TGs [ 45 ], an aspect that remains to be elucidated in the present model.…”

Section: Discussionmentioning

confidence: 99%

Attenuation of High‐Fat Diet‐Induced Rat Liver Oxidative Stress and Steatosis by Combined Hydroxytyrosol‐ (HT‐) Eicosapentaenoic Acid Supplementation Mainly Relies on HT

Echeverría

Valenzuela

Bustamante

et al. 2018

Oxidative Medicine and Cellular Longevity

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Pharmacological therapy for nonalcoholic fatty liver disease (NAFLD) is not approved at the present time. For this purpose, the effect of combined eicosapentaenoic acid (EPA; 50 mg/kg/day) modulating hepatic lipid metabolism and hydroxytyrosol (HT; 5 mg/kg/day) exerting antioxidant actions was evaluated on hepatic steatosis and oxidative stress induced by a high-fat diet (HFD; 60% fat, 20% protein, and 20% carbohydrates) compared to a control diet (CD; 10% fat, 20% protein, and 70% carbohydrates) in mice fed for 12 weeks. HFD-induced liver steatosis (i) was reduced by 32% by EPA, without changes in oxidative stress-related parameters and mild recovery of Nrf2 functioning affording antioxidation and (ii) was decreased by 42% by HT, concomitantly with total regain of the glutathione status diminished by HFD, 42% to 59% recovery of lipid peroxidation and protein oxidation enhanced by HFD, and regain of Nrf2 functioning, whereas (iii) combined EPA + HT supplementation elicited 74% reduction in liver steatosis, with total recovery of the antioxidant potential in a similar manner than HT. It is concluded that combined HT + EPA drastically decreases NAFLD development, an effect that shows additivity in HT and EPA effects that mainly relies on HT, strengthening the impact of oxidative stress as a central mechanism underlying liver steatosis in obesity.

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Role of dietary α- and γ-tocopherol from Rosa mosqueta oil in the prevention of alterations induced by high-fat diet in a murine model

Cited by 7 publications

References 42 publications

Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation

Modulatory Properties of Food and Nutraceutical Components Targeting NLRP3 Inflammasome Activation

Crude and refined millet bran oil alleviate lipid metabolism disorders, oxidative stress and affect the gut microbiota composition in high‐fat diet‐induced mice

Attenuation of High‐Fat Diet‐Induced Rat Liver Oxidative Stress and Steatosis by Combined Hydroxytyrosol‐ (HT‐) Eicosapentaenoic Acid Supplementation Mainly Relies on HT

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