Role of Dietary Zinc as a Nutritional Immunomodulator

Goswami, T. K.; Bhar, R.; Jadhav, S.E.; Joardar, Siddhartha Narayan; Ram, G. C.

doi:10.5713/ajas.2005.439

Cited by 29 publications

(24 citation statements)

References 111 publications

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“…Zinc is a cofactor for more than 300 enzymes, involved in cell proliferation, DNA replication and signal transduction (Coleman 1992). Zinc deficiency causes reduced peripheral T cell counts, oxidative burst and T cell dependent antibody production (Goswami et al 2005). Lambs fed on a semi-purified diet severely deficient in zinc (3.7 mg Zn/kg) showed a reduced blastogenic response to PHA with lower percentage of lymphocytes in lambs (Droke and Spears 1993).…”

Section: Discussionmentioning

confidence: 99%

Effect of dose and source of supplemental zinc on immune response and oxidative enzymes in lambs

2009

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An experiment of 150 days was conducted on 42 male Nellore lambs (28.3 +/- 0.64 kg) to determine the effect of zinc (Zn) supplementation (0,15, 30 and 45 ppm) in diet from inorganic (ZnSO(4)) and organic (Zn proteinate) sources on immune response and antioxidant enzyme activities by allotting them randomly to 7 groups in completely randomized design. The basal diet (BD) contained 29.28 ppm Zn. The humoral immune response assessed at 75 d against B. abortus was higher (P<0.01) with 15 or 30 ppm Zn supplementation from organic source. The dose and source had no effect on titres against chicken RBC antigen. The cell mediated immune response assessed as delayed type hypersensitivity (DTH) response against phytohaemagglutinin-P and in vitro lymphocyte proliferative response against concanavalin A at 150 d was higher (P<0.05) at 15 ppm Zn supplementation compared to BD fed lambs. Supplementation of 45 ppm Zn had no positive effect on immune response. The DTH response and antibody titres against B.abortus were higher (P< 0.05) on Zn proteinate compared to ZnSO(4) at 15 ppm Zn supplementation. The lipid peroxidase activity was lower (P < 0.01), while the RBC superoxide dismutase and catalase activities were higher (P < 0.01) in lambs at 15 ppm Zn supplementation compared to BD diet fed lambs, assessed at 75 d of feeding. Serum globulin concentration and alkaline phosphatase (ALP) activity (75 d of experiment) was higher in Zn supplemented lambs. The ALP activity increased (P < 0.01) with increase in Zn supplementation and being higher when supplementation was from Zn proteinate compared to ZnSO(4). The study indicated that 15 ppm zinc supplementation was required for obtaining higher immune response in lambs when fed a basal diet containing 29.28 ppm Zn and supplementation as Zn proteinate had higher antioxidant enzyme activities and immune response compared to ZnSO(4).

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Section: Discussionmentioning

confidence: 99%

Effect of dose and source of supplemental zinc on immune response and oxidative enzymes in lambs

2009

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“…A potential explanation of the role of zinc is that it is second only to iron as the most abundant trace metal found in eukaryotic organisms . It is a cofactor for more than 300 enzymes associated with DNA replication, signal transduction, and cell proliferation, particularly that taking place in immune cells (T and B cells) that produce immunoglobulins and cytokines . Regarding EHV‐1‐induced myeloencephalopathy, cytotoxic T‐lymphocytes (CTL) are recognized as important for controlling the magnitude of postinfection leukocyte‐associated viremia and subsequent development of neurologic disease .…”

Section: Discussionmentioning

confidence: 99%

“…11 It is a cofactor for more than 300 enzymes associated with DNA replication, signal transduction, and cell proliferation, particularly that taking place in immune cells (T and B cells) that produce immunoglobulins and cytokines. 11,12 Regarding EHV-1-induced myeloencephalopathy, cytotoxic T-lymphocytes (CTL) are recognized as important for controlling the magnitude of postinfection leukocyte-associated viremia and subsequent development of neurologic disease. 1 One study has implicated low pre-exposure concentrations of CTL precursor cells in horses as a predisposing factor of horses to the neuropathogenic form of EHV-1.…”

Section: Discussionmentioning

confidence: 99%

Case–Control Study of a Multistate Equine Herpesvirus Myeloencephalopathy Outbreak

Traub‐Dargatz

Pelzel‐McCluskey²,

Creekmore³

et al. 2013

Veterinary Internal Medicne

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Background: A large multistate outbreak of equine herpesvirus myeloencephalopathy (EHM) occurred in May 2011 among horses that participated in a competitive event.Objective: To identify EHM risk factors among horses with a common exposure venue. Animals: A total of 123 horses: 19 horses with EHM, 14 equine herpesvirus-1 cases with no reported neurologic signs, and 90 control horses.Methods: EHM case survey data were compared with data from EHV-1 cases with no neurologic signs and healthy controls using univariable and multivariable methods.Results: Significant factors associated with higher risk for EHM compared with EHV-1 cases with no neurologic signs were (1) greater number of biosecurity risks at the event, (2) female sex, (3) increasing number of classes competed in at the event, and (4) an interaction between sex and number of classes competed in. In the EHM versus controls comparison, in addition to sex and biosecurity risks, factors associated with higher EHM risk included EHV-1 vaccination in the 5 weeks before the event and increasing number of events attended in April 2011; zinc dietary supplementation was associated with decreased risk. An interaction between sex and the number of events attended in April 2011 also was significant.Conclusions and Clinical Importance: Findings from this study suggest that dietary zinc supplementation may be associated with decreased risk of EHM. Several factors were associated with increased risk of EHM. Additional investigations of factors associated with risk of EHM are warranted to evaluate the importance of these factors in this complex disease of horses.

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“…На ґрунті нестачі макро-і мікроелементів досить поширеним захворюванням серед худоби є ензоотична остеодистрофія (ЕО) (Pu, Chen, & Xue, 2016;Zhou, Xue, & Yang, 2013). Ряд вчених (Berger, 1996;Khan, 2003;Goswami, Bhar, Jadhav, Joardar, & Ram, 2005) етіології виникненню ензоотичних хвороб тварин в західній біогеохімічній зоні надають ролі в цих процесах вмісту мінеральних речовин, зокрема мікроелементів в ґрунтах і кормах. Поряд з цим багато питань етіології, патогенезу, діагностики, профілактики і лікування ЕО худоби вимагають уточнення, доповнення і нових розробок (Alonso et al, 2004;Blanco-Penedo, Shore, Miranda, Benedito, & López-Alonso, 2009;Tame, 2012).…”

Section: сумской национальный аграрный университет сумы украинаunclassified

Interconnection of biochemical indices in blood of cows and heifers with birth defects

Serеdzhimova¹

2019

VTTP

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The main essential factor in obtaining a sufficient number of viable litters is the prevention of pregnancy and childbirth pathology in cows. It is known that birth is a complex physiological process, which requires the coordinated activity of virtually all organs and systems of the body. This, in turn, requires a positive energy balance and clear neuro-humoral regulation. The guarantee of the latter is full feeding, which includes optimal mineral supply of cows during the dry period, childbirth and postpartum period. The aim of research was to link the lack of balance of microelements and pathology of the second and third stages of parturition of cows. To develop prognostic tests for the signification of birth pathology on the basis of the interconnection between micro-and microelement imbalances and some biochemical indices of cow blood. In the first phase of research we have formed 2 groups of cows and 2 groups of heifers. All animals were of Simmental breed. The first group of cows-16 heads, aged 5 years, weighing 550 ± 50 kg, afterwards had pathological parturitions, the second group of cows-27 heads were the same age and had the same weight. Heifers were two years old, weighing about 400 ± 27,5 kg. Groups of heifers were formed in the same way: 1 group (5 heads) had further pathological parturition, 2 group (7 heads)-were physiologically calved. 2-4 days before the expected delivery, all animals were sampled from the tail vein and blood serum. Blood plasma (to study the content of micro-and macronutrients) was selected in a syringe with heparin as an anticoagulant ohm. In the second stage of the research, the obtained data were analyzed and test was developed to predict pathological birth in cows and heifers. According to the research, the content of zinc in the group, with observed pathological birth was at the level of 70,27 ± 4,81 µg %, which is significantly lower than in the group of cows, that afterwards had a physiological course of parturition. A similar trend was observed for us regarding iron content. The enzymatic activity of the liver should also be taken into account. Thus, in the group with further pathological parturition, in the period of late dryness, the creatinine level was

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Role of Dietary Zinc as a Nutritional Immunomodulator

Cited by 29 publications

References 111 publications

Effect of dose and source of supplemental zinc on immune response and oxidative enzymes in lambs

Effect of dose and source of supplemental zinc on immune response and oxidative enzymes in lambs

Case–Control Study of a Multistate Equine Herpesvirus Myeloencephalopathy Outbreak

Interconnection of biochemical indices in blood of cows and heifers with birth defects

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