Abstract:In periodontitis, one of the major pathologic patterns is an increased production of reactive oxygen species (ROS). Reactive oxygen species are produced by polymorph nuclear cells as an inflammatory response to invading pathogenic bacteria. This imbalance among the production of free radicals and local antioxidants results in periodontal tissue destruction and a state of oxidative stress develops. In recent years, beneficial effects of antioxidants against various chronic disorder induced by oxidative stress h… Show more
“…Excessive ROS production plays a role in the pathogenesis of various chronic inflammatory diseases, including periodontal disease [2] (Figure 1). Cells and tissues require antioxidants to prevent the tissue damage caused by overproduction of ROS [3].…”
Excessive reactive oxygen species production plays an important role in the pathogenesis of various chronic inflammatory diseases, including periodontal disease. Reactive oxygen species could damage the cells and the tissues. In the pathogenesis of periodontal diseases, the increased PMN count and activity cause a high rate of ROS release. This leads to increased oxidative stress in periodontal tissues. Periodontal tissues require adequate levels of antioxidants to prevent tissue damage caused by reactive oxygen species. The use of antioxidants in the treatment of periodontal disease and periodontal health has gained importance in recent studies. Antioxidants can be used to treat periodontal disease locally or systemically. Therefore, this chapter focuses on the effects of antioxidant on periodontal tissues.
“…Excessive ROS production plays a role in the pathogenesis of various chronic inflammatory diseases, including periodontal disease [2] (Figure 1). Cells and tissues require antioxidants to prevent the tissue damage caused by overproduction of ROS [3].…”
Excessive reactive oxygen species production plays an important role in the pathogenesis of various chronic inflammatory diseases, including periodontal disease. Reactive oxygen species could damage the cells and the tissues. In the pathogenesis of periodontal diseases, the increased PMN count and activity cause a high rate of ROS release. This leads to increased oxidative stress in periodontal tissues. Periodontal tissues require adequate levels of antioxidants to prevent tissue damage caused by reactive oxygen species. The use of antioxidants in the treatment of periodontal disease and periodontal health has gained importance in recent studies. Antioxidants can be used to treat periodontal disease locally or systemically. Therefore, this chapter focuses on the effects of antioxidant on periodontal tissues.
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