Role of Diet in the Development and Management of Crohn’s Disease

Goens, Donald; Micic, Dejan

doi:10.1007/s11894-020-0755-9

Cited by 11 publications

(10 citation statements)

References 69 publications

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“…For example, recent studies figured out that a higher intake of dietary fiber leads to a lower risk for CD. 22 , 23 Here the genetic association study only focused on pediatric CD patients. There is no denying that the number of pediatric patients 86 is small, but pediatric CD patients are more difficult to enroll and more valuable as the CD ratio in children is apparently smaller than in adults.…”

Section: Discussionmentioning

confidence: 99%

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Association of polymorphisms in the IL‐10 promoter region with Crohn's disease

Sun

Shang

2022

Clinical Laboratory Analysis

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As an inflammatory bowel disease (IBD), Crohn's disease (CD) is known for its complex etiology and serious family life impairment, including psychological health. 1 It was once recognized as no known cure for inflammation that may involve any part of the gastrointestinal tract. 2 CD was reported with a high incidence in western countries. 3,4 In recent years, the incidence of CD has been gradually increasing in China. 5,6 Despite the low incidence of CD in China, the rising momentum of this complex disease in children still raises public concerns in the country. Because young CD patients, especially pediatric patients, are at higher risk of obstinacy or recurrence. 7 Till now, the exact genetic mechanism of CD remains unclear.Given many clues in hand, a deep insight into high-risk genes is urgently needed. The disease is featured with familial aggregation, which means the disease appears more frequently than expected in specific families. 8 According to European and American literature statistics, the first-blood relatives of patients with CD or ulcerative

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Section: Discussionmentioning

confidence: 99%

“…CD is highly related to genetic background, age, race, and diet habits. For example, recent studies figured out that a higher intake of dietary fiber leads to a lower risk for CD 22,23 . Here the genetic association study only focused on pediatric CD patients.…”

Section: Discussionmentioning

confidence: 99%

Association of polymorphisms in the IL‐10 promoter region with Crohn's disease

Sun

Shang

2022

Clinical Laboratory Analysis

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“…One study showed a positive effect on the occurrence of CD in the population of French women of middle age [3]. Whereas another overviev study found no effect of protein intake on disease manifestation [4]. Through this, the association of protein ingestion with this disease should be confirmed by broader targeted studies.…”

Section: Impact Of Nutritional Factorsmentioning

confidence: 95%

“…High consumption of fiber may decrease risk of CD, thus consumption of vegetables and fruits may be useful to reduce risk of CD [4,15]. Especially fruit fibers seem to be better at preventing disease than fibers from vegetables or cereals [16,17].…”

Section: Impact Of Nutritional Factorsmentioning

confidence: 99%

Unveiling the power of diet and lifestyle in managing Crohn’s disease

BIALIC

BAKALARCZYK³

et al. 2023

J Educ Health Sport

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Introduction: Crohn's disease (CD) is an inflammatory bowel disease that can affect any part of the digestive tract. Onset, progression, complications and treatment are influenced by many genetic, environmental and dietary factors. Dietary management is very useful in a variety of gastrointestinal diseases, including CD. Some nutrients have been studied in animal models to exacerbate the disease, while others have strong scientific evidence from large studies in human populations, allowing conclusions to be drawn about their impact on the disease. Dietary management is now a well-established and important part of treatment, in addition to the use of systemic corticosteroids, aminosalicylates, immunomodulators (e.g. azathioprine, 6-mercaptopurine, cyclosporine, tacrolimus) or biologic therapies. State of knowledge: To test the associations between the intake of specific macronutrients and the course of CD, we searched the PubMed database focusing on articles about the effects of consumed food components and stimulants on the onset and progression of CD. Conclusion: Nutritional treatment plays an important role in the management of CD. An appropriate diet can make a significant contribution to reducing inflammation and attenuating the course and exacerbations of the disease. The intake of proteins, fats, carbohydrates, fiber and certain food additives has been shown in studies to influence the onset and course of CD.

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“…One of the possible mechanisms of disorders is the presence of some specific antigen in the intestinal lumen/blood of patients, leading to the activation of T-lymphocytes and cellular macrophages, to the production of antibodies, cytokines, prostaglandins, and active forms of nitrogen and reactive oxygen species, which activate oxidative and nitrosative stress and cause the formation of nitrogen dioxide (NO 2 ) and OH radicals and peroxynitrite capable of causing various damage to cells and tissues [52][53][54]. Exclusive enteral nutrition is a common method in the treatment of the active stage of Crohn's disease [55,56].…”

Section: Immunological Factorsmentioning

confidence: 99%

Causal Relationship between Physiological and Pathological Processes in the Brain and in the Gastrointestinal Tract: The Brain–Intestine Axis

Реутов

Sorokina

2022

BIOPHYSICS

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The brain and gastrointestinal tract are the most important organs responsible for detecting, transmitting, integrating, and responding to signals coming from the internal and external environment. A bidirectional system of neurohumoral communication (the "intestine-brain" axis) combines the activity of the intestine and brain (or brain and intestine) of a person. It affects human development and behavior. This paper analyzes the literature data on the existence of a relationship between the central and enteral nervous systems. Based on data on the number of neurons in the enteral nervous system (approximately 250 million nerve cells), the concept of a "second brain" in the intestine has been proposed in foreign literature, which, by its influence on the brain, can have a more powerful influence than the spinal cord (approximately 10 million neurons) with its autonomic nervous system. However, it turned out that Russian scientists, academicians of the Academy of Sciences of the Soviet Union I.P. Pavlov, K.M. Bykov, and A.M. Ugolev, analyzed cortical-visceral relationships in the 20th century and wrote about the existence of a connection between the central and enteral nervous systems. One of the urgent problems of modern physiology, pathophysiology, biophysics, biochemistry, and medicine is to clarify the causal relationship between the central and enteral nervous systems, as well as between neurological, mental, and gastrointestinal diseases in order to combine the efforts of specialists of various medical and biological profiles to solve urgent medical problems.

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Role of Diet in the Development and Management of Crohn’s Disease

Cited by 11 publications

References 69 publications

Association of polymorphisms in the IL‐10 promoter region with Crohn's disease

Association of polymorphisms in the IL‐10 promoter region with Crohn's disease

Unveiling the power of diet and lifestyle in managing Crohn’s disease

Causal Relationship between Physiological and Pathological Processes in the Brain and in the Gastrointestinal Tract: The Brain–Intestine Axis

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