Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis

Massart, Julie; Zierath, Juleen R.

doi:10.1016/j.tem.2019.06.003

Cited by 21 publications

(13 citation statements)

References 101 publications

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“…LPA can be obtained from glycerol-3-phosphate (G3P) thanks to the enzymatic action of glycerol-3-phosphate acyltransferase (GPAT). (ii) From the hydrolysis of phosphatidylcholine by the phospholipase D. (iii) From the phosphorylation of diacylglycerol (DAG) by a diacylglycerol kinase (DGK 10 isoforms in human) [ 13 , 15 ]. Importantly, PA is a major precursor of PL biosynthesis.…”

Section: Basic Concepts On Plsmentioning

confidence: 99%

Phospholipids: Identification and Implication in Muscle Pathophysiology

Bargui

Solgadi

Prost

et al. 2021

IJMS

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Phospholipids (PLs) are amphiphilic molecules that were essential for life to become cellular. PLs have not only a key role in compartmentation as they are the main components of membrane, but they are also involved in cell signaling, cell metabolism, and even cell pathophysiology. Considered for a long time to simply be structural elements of membranes, phospholipids are increasingly being viewed as sensors of their environment and regulators of many metabolic processes. After presenting their main characteristics, we expose the increasing methods of PL detection and identification that help to understand their key role in life processes. Interest and importance of PL homeostasis is growing as pathogenic variants in genes involved in PL biosynthesis and/or remodeling are linked to human diseases. We here review diseases that involve deregulation of PL homeostasis and present a predominantly muscular phenotype.

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Section: Basic Concepts On Plsmentioning

confidence: 99%

Phospholipids: Identification and Implication in Muscle Pathophysiology

Bargui

Solgadi

Prost

et al. 2021

IJMS

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“…TRPC6 can be activated by DAG, store-depletion, Hyperforin (St. John's wort extract), or H 2 O 2 (Bouron et al, 2016). DAG is a second messenger that acts as a regulator of key signaling molecules, cellular membrane constituents, and fatty acid metabolism (Massart and Zierath, 2019). It is widely accepted that activation of TRPC6 channels by DAG promotes various cellular responses, although the precise underlying mechanisms remain to be elucidated.…”

Section: Structure and Characteristics Of Trpc6mentioning

confidence: 99%

Novel Targets for Stroke Therapy: Special Focus on TRPC Channels and TRPC6

Liu

Chen

et al. 2020

Front. Aging Neurosci.

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Stroke remains a leading cause of death, disability, and medical care burden worldwide. However, transformation from laboratory findings toward effective pharmacological interventions for clinical stroke has been unsatisfactory. Novel evidence has been gained on the underlying mechanisms and therapeutic potential related to the transient receptor potential (TRP) channels in several disorders. The TRP superfamily consists of a diverse group of Ca 2+ permeable non-selective cation channels. In particular, the members of TRP subfamilies, TRP canonical (TRPC) channels and TRPC6, have been found in different cell types in the whole body and have high levels of expression in the central nervous system (CNS). Notably, the TRPCs and TRPC6 channel have been implicated in neurite outgrowth and neuronal survival during normal development and in a range of CNS pathological conditions. Recent studies have shown that suppression of TRPC6 channel degradation prevents ischemic neuronal cell death in experimental stroke. Accumulating evidence supports the important functions of TRPC6 in brain ischemia. We have highlighted some crucial advancement that points toward an important involvement of TRPCs and TRPC6 in ischemic stroke. This review will make an overview of the TRP and TRPC channels due to their roles as targets for clinical trials and CNS disorders. Besides, the primary goal is to discuss and update the critical role of TRPC6 channels in stroke and provide a promising target for stroke prevention and therapy.

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“…A study from Massart and Zierath (2019) on the movement of diacylglycerol kinases during the metabolism of glucose and the energy consumed for cell homeostasis showed that DGK genes are present in various subcellular compartments and that their activities are closely dependent on extracellular stimuli, binding partners, and DAG availability [59]. Additionally, in quiescent cells, DGK activity remains very low but quickly increases upon stimuli; therefore, it can create different pools of DGK activities during eukaryotic cell metabolism [28].…”

Section: Subcellular Localization and Tissue Distribution Of Dgk Genesmentioning

confidence: 99%

“…The movement of DGK enzymes in different cell compartments mostly results from the intensity or the nature of the stimulation. For example, in mammalian cells, inactive DGKα switches into the plasma membrane in an active form during the calcium-dependent cell signaling pathway in response to the stimulation of extracellular receptors or cell-surface receptors [59]. In plants, a fusion recombinant protein method was used to characterize the subcellular localization of many DGK isoforms [53].…”

Section: Subcellular Localization and Tissue Distribution Of Dgk Genesmentioning

confidence: 99%

The Emerging Roles of Diacylglycerol Kinase (DGK) in Plant Stress Tolerance, Growth, and Development

et al. 2020

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Diacylglycerol kinase (DGK) is recognized as the key enzyme of the lipid signaling pathway, which involves the transduction of messages from hormones, neurotransmitters, and immunologic and growth factors. Regarding their essential role in animal physiology, many plant biologists have predicted a similar enzymatic influence in plants. However, a small number of recent studies have revealed the complexity of the involvement of DGK genes in the modulation of plant growth, development, and adaptation in both biotic and abiotic stress conditions. Here, we describe recent discoveries on the role of DGK genes in the plants’ responses to biotic or abiotic stressors. Moreover, we discuss how DGK enzymes regulate plant cellular activities during the adaptation of plants to a readily changing environment. DGK is an enzyme that plays a pivotal role in plant lipid signaling, by catalyzing the phosphorylation of the diacylglycerol (DAG) to phosphatidic acid (PA), which is a crucial molecule in a plant’s metabolic network, leading to its response to various external stresses. DGK enzymes are the principal moderators of PA generation in plant cells; this consequently affects its derived products—hence, enabling their activities in lipid signaling networks and cell homeostasis. Thus, understanding the DGK operational mode and interactions between the production and accumulation of PA would constitute a significant advancement in investigating the mechanism of stress adaptation in plants.

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Role of Diacylglycerol Kinases in Glucose and Energy Homeostasis

Cited by 21 publications

References 101 publications

Phospholipids: Identification and Implication in Muscle Pathophysiology

Phospholipids: Identification and Implication in Muscle Pathophysiology

Novel Targets for Stroke Therapy: Special Focus on TRPC Channels and TRPC6

The Emerging Roles of Diacylglycerol Kinase (DGK) in Plant Stress Tolerance, Growth, and Development

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