Role of Dexamethasone in Reducing Pain after Endoscopic Sinus Surgery in Adults: A Double-Blind Prospective Randomized Trial

Abstract

Dexamethasone injection at the time of induction of general anesthesia is not superior to placebo in controlling early postoperative pain in patients who undergo endoscopic sinus surgery.

Endoscopic sphenopalatine ganglion blockade efficacy in pain control after endoscopic sinus surgery

“…Our patients’ pain severity level is consistent with those reported in the literature . Generally, POP after FESS reaches a peak during the first 24 hours and then both pain severity and the need of analgesic medications decrease over the postoperative time.…”

“…Inadequate POP control can delay recovery, necessitate rehospitalization, increase healthcare costs, reduce patient satisfaction, and more importantly, increase the risk for pulmonary and cardiovascular complications. Although there is a worldwide undersupply of adequate pain management after surgery, there is no consensus agreement protocol for POP management after FESS …”

Perioperative analgesia for patients undergoing endoscopic sinus surgery: an evidence‐based review

“…No other systematic review or meta‐analysis was found pertaining to perioperative and postoperative analgesic use for endoscopic sinus surgeries. Thirty‐two studies met the inclusion criteria for this project: all of the included studies were randomized, controlled trials (RCTs). Using the Cochrane Bias tool, we judged 4 studies to be at high risk, 21 to be at moderate risk, 6 to be at low risk, and 1 to be at unclear risk of bias.…”

Perioperative Single Dose Systemic Dexamethasone for Postoperative Pain

“…Among the studies evaluating low dose dexamethasone, two did not comment on adverse side effects. 29,32 Three studies reported no difference in adverse side effects, 33,45,50 two spe- cifically reported no difference in postoperative wound infection, 30,34 and one study specifically reported no cases with delayed wound healing. 30 One study reported no difference in changes of blood glucose between the dexamethasone and placebo group.…”

“…Five studies examined the effects of low-dose dexamethasone on late pain at rest. 29,30,31,33,45 One study 45 provided two comparisons and both were included in the analysis. A positive effect on late pain at rest of Ϫ0.47 (Ϫ0.68 to Ϫ0.25) was observed.…”