Role of derived neutrophil-to-lymphocyte ratio, uric acid-to-creatinine ratio and Delta neutrophil index for predicting neonatal outcomes in pregnancies with preeclampsia

Yakıştıran, Betül; Altınboğa, Orhan; Erol, Seyit Ahmet; Şenel, Selvi; Yücel, Aykan

doi:10.1080/01443615.2022.2040968

Cited by 14 publications

(16 citation statements)

References 27 publications

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“…To the best of our knowledge, only a recent retrospective case control study has investigated SUA/sCr during pregnancy, in women with preeclampsia and healthy controls (n ¼ 84 and n ¼ 86, respectively) [29]. The authors found that women with preeclampsia had higher SUA/sCr compared with healthy controls and that SUA/sCr positively associated with platelet-to-lymphocyte ratio of newborns.…”

Section: Discussionmentioning

confidence: 99%

“…However, Yakiştiran et al . [29] did not compare the trends of SUA/sCr in all trimesters of pregnancy among women with HDP non-preeclampsia, women with preeclampsia, and women with normotensive pregnancies. Furthermore, they did not assess the associations between SUA/sCr during pregnancy and the odds of maternal and neonatal adverse outcomes.…”

Section: Discussionmentioning

confidence: 99%

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Serum uric acid to creatinine ratio and risk of preeclampsia and adverse pregnancy outcomes

Piani,

Agnoletti,

Baracchi

et al. 2023

Journal of Hypertension

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Objective: Preeclampsia is one of the most severe diseases among the hypertensive disorders of pregnancy (HDP) and the leading cause of maternal and fetal morbidity and mortality. It is of crucial importance to early identify women at a high risk for preeclampsia to implement appropriate preventive strategies. In our study, we aimed to test the hypothesis that serum uric acid to creatinine ratio (SUA/sCr) is related to the development of preeclampsia and maternal and neonatal complications. Methods: We searched for uric acid and creatine values in the medical records of 269 women who consecutively attended our HDP Clinic from December 2018 to December 2022. We compared the baseline characteristics of participants with normotensive pregnancy (n = 57), to those with HDP without preeclampsia (HDP-non-PE) (n = 100) and those with preeclampsia (n = 112), and we performed adjusted logistic regression analysis to test the associations between SUA/sCr and the development of preeclampsia and maternal and neonatal complications. Results: SUA/sCr was consistently higher in women with preeclampsia in all trimesters of pregnancy. Higher SUA/sCr at the third trimester was associated with an increased odd of developing preeclampsia [odds ratio (OR) 1.29, confidence interval (CI) 1.15–1.50, P = 0.001], preterm birth (OR 1.23, CI 1.05–1.45, P = 0.011), and composite neonatal outcome (OR 1.33, CI 1.12–1.59, P = 0.001), after adjustment for age, BMI before pregnancy, nulliparity, antihypertensive therapy, and acetylsalicylic acid therapy during pregnancy. Conclusions: Having higher SUA/sCr during pregnancy is associated with the development of PE and adverse pregnancy outcomes. Controlled prospective studies are warranted to clarify the predictive power of this novel marker during pregnancy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Serum uric acid to creatinine ratio and risk of preeclampsia and adverse pregnancy outcomes

Piani,

Agnoletti,

Baracchi

et al. 2023

Journal of Hypertension

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“…PE is a systemic vascular disorder with signs of metabolic disease or a combination of different types of organ dysfunction. Many biomarkers have been studied for PE diagnosis and prediction, such as placenta-derived biomarkers (sENG, soluble fms-related receptor tyrosine kinase 1 and placental growth factor [ 8 , 9 ] ), serum metabolomics (proline betaine and proline [ 21 ] ), and inflammatory factors (interleukin 6, [ 11 ] neutrophil-to-lymphocyte ratio [ 12 ] ). However, owing to the complexity and testing limitations of the above-mentioned biomarkers, clinical manifestations, hypertension, and proteinuria are still required to diagnose PE and evaluate its severity.…”

Section: Discussionmentioning

confidence: 99%

Fibrinogen to albumin ratio, a novel serum indicator for evaluating the severity of preeclampsia: A single-center retrospective study

et al. 2023

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Preeclampsia (PE) is a disorder that affects approximately 5% to 10% of pregnant women. Timely and accurate identification of PE and assessment of its severity are crucial. Therefore, it is necessary to develop predictive indicators which are easily measured in routine antenatal examinations to enable the early detection of PE and assess its severity. We designed a single-center retrospective study in our daily work to assess whether the serum levels of fibrinogen to albumin ratio (FAR), fibrinogen (Fib), albumin (ALB), prothrombin time, calcium (Ca), activated partial thrombin time, creatinine (Cr), D-dimer(D-D), platelet, white blood cell, neutrophil, and lymphocyte counts could help in assessing PE and evaluating its severity. Our findings showed that the serum levels of FAR, Cr, Fib, and D-D were significantly higher in the severe preeclampsia group (sPE) compared with the control and mild preeclampsia groups, whereas the levels of ALB and Ca were significantly lower in sPE patients. In addition, no differences were found between the control and PE groups in terms of prothrombin time, activated partial thrombin time, platelet, white blood cell, neutrophils, and lymphocytes counts. Furthermore, FAR is a novel and better indicator for evaluating the severity of PE, which has not been reported before. And it is an independent risk factor for the development of sPE. In conclusion, the serum levels of FAR, Cr, D-D and Fib were positively correlated with PE, whereas ALB and Ca were negatively correlated with PE severity, which might be valuable in evaluating the severity of PE. FAR proved to be a feasible diagnostic marker for sPE with sensitivity and specificity comparable to those of ALB and Fib.

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“…In the past several years, some indicators of maternal complete blood count indices blood cell had been identified as predictors of PE, such as WBC and neutrophil count [ 24 ], higher neutrophil-lymphocyte ratio [ 7 ], and platelet-to-lymphocyte ratio [ 13 ]. A retrospective study showed that neutrophil-to-lymphocyte ratio could predict preeclampsia with sensitivity and specificity rates of 79.1% and 38.7% [ 25 ], however, there were no large-scale and prospective studies to reproduce these results, although these test results were cheap and easily accessible, predictability of these biomarkers still needed to be verified.…”

Section: Discussionmentioning

confidence: 99%

“…Even though the pathogenesis of PE remains largely unknown, studies suggested that it may be related to the exaggeration of the systemic inflammatory process [ 6 , 7 ], and more importantly some other studies considered it as an exaggerated intravascular inflammatory response to pregnancy [ 3 , 8 , 9 ]. In addition, intravascular inflammatory response is known to be related to inflammatory cytokines released from WBC.…”

Section: Introductionmentioning

confidence: 99%

Impact of elevated first and second trimester white blood cells on prevalence of late-onset preeclampsia

Wu¹,

Gong²,

et al. 2022

Heliyon

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Role of derived neutrophil-to-lymphocyte ratio, uric acid-to-creatinine ratio and Delta neutrophil index for predicting neonatal outcomes in pregnancies with preeclampsia

Cited by 14 publications

References 27 publications

Serum uric acid to creatinine ratio and risk of preeclampsia and adverse pregnancy outcomes

Serum uric acid to creatinine ratio and risk of preeclampsia and adverse pregnancy outcomes

Fibrinogen to albumin ratio, a novel serum indicator for evaluating the severity of preeclampsia: A single-center retrospective study

Impact of elevated first and second trimester white blood cells on prevalence of late-onset preeclampsia

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