Role of dentin cross-linking agents in optimizing dentin bond durability

Abu-Nawareg, Manar; Abuelenain, Dalia A.; Elkassas, Dina; Haimed, Tariq S. Abu; Al-Dharrab, Ayman; Zidan, Ahmed; Hassan, Ali; Pashley, David H.

doi:10.1016/j.ijadhadh.2017.06.009

Cited by 10 publications

(18 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 50 articles were included in the qualitative analysis. Of these, 5 articles were not considered for the meta-analysis because two of them did not express the BS data as means and SDs [ 76 , 77 ], and in 3 articles the number of specimens used could not be retrieved [ 78 , 79 , 80 ], totalling 45 articles considered for the quantitative analysis [ 17 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 , 119 , 120 , 121 , 122 , 123 , 124 , 125 ]. A flowchart designating the study selection process according to the PRISMA statement is presented in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis

Hardan

Daood

Bourgi

et al. 2022

Cells

View full text Add to dashboard Cite

This study aimed to identify the role of crosslinking agents in the resin–dentin bond strength (BS) when used as modifiers in adhesives or pretreatments to the dentin surface through a systematic review and meta-analysis. This paper was conducted according to the directions of the PRISMA 2020 statement. The research question of this review was: “Would the use of crosslinkers agents improve the BS of resin-based materials to dentin?” The literature search was conducted in the following databases: Embase, PubMed, Scielo, Scopus, and Web of Science. Manuscripts that reported the effect on the BS after the use of crosslinking agents were included. The meta-analyses were performed using Review Manager v5.4.1. The comparisons were performed by comparing the standardized mean difference between the BS values obtained using the crosslinker agent or the control group. The subgroup comparisons were performed based on the adhesive strategy used (total-etch or self-etch). The immediate and long-term data were analyzed separately. A total of 50 articles were included in the qualitative analysis, while 45 articles were considered for the quantitative analysis. The meta-analysis suggested that pretreatment with epigallocatechin-3-gallate (EGCG), carbodiimide, ethylenediaminetetraacetic acid (EDTA), glutaraldehyde, and riboflavin crosslinking agents improved the long-term BS of resin composites to dentin (p £ 0.02). On the other hand, the use of proanthocyanidins as a pretreatment improved both the immediate and long-term BS values (p ≤ 0.02). When incorporated within the adhesive formulation, only glutaraldehyde, riboflavin, and EGCG improved the long-term BS to dentin. It could be concluded that the application of different crosslinking agents such as carbodiimide, EDTA, glutaraldehyde, riboflavin, and EGCG improved the long-term BS of adhesive systems to dentin. This effect was observed when these crosslinkers were used as a separate step and when incorporated within the formulation of the adhesive system.

show abstract

Section: Resultsmentioning

confidence: 99%

Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis

Hardan

Daood

Bourgi

et al. 2022

Cells

View full text Add to dashboard Cite

show abstract

“…This was in accordance with many previous studies. 1,3,6,16,30,36,42 Hybrid layer degradation has compromised the bonding stability of resin-dentin interfaces. 2,42 Many factors were reported to be responsible for such degradation, 1,2 including the degree of conversion 43,44 and hydrophilicity 45,46 of adhesive resins, as well as the host-derived MMPs and cysteine cathepsins.…”

Section: Discussionmentioning

confidence: 99%

“…16,34,43 When crosslinking agents are applied on acidetched dentin, they inactivate MMPs that are hydrolases. 6,19,23,[26][27][28][29][30] They also hinder the unwinding action of collagen triple helix which enables collagenases to cleave all polypeptides present in the collagen molecule, thus, increasing the hydrolytic degradation resistance of collagen. 48 In the present study, when the acid-etched dentin was treated with chitosan solution (0.1 mol/L acetic acid) for 60s, prior to application of Adper Single Bond 2, no significant change has occurred in the 24 h microtensile bond strength and nanoleakage values.…”

Section: Discussionmentioning

confidence: 99%

Effect of chitosan on resin-dentin interface durability: A 2 year in-vitro study

Zidan

2019

Egyptian Dental Journal

View full text Add to dashboard Cite

Aim: The aim of the current study was to evaluate immediate and long-term bonding effectiveness of chitosan-treated dentin, bonded using 2-step etch-and-rinse dental adhesive, after 2 years of ageing. Materials & Methods: Microtensile bond strength test and nanoleakage examination of resin-dentin interfaces, created by Adper Single Bond 2 with or without chitosan pre-treatment, were performed after 24 h, 12 mos and 24 mos of water storage. Stiffness of demineralized dentin sticks treated with chitosan for 1 or 10 min was evaluated. Matrix metalloproteinases (MMPs) activity was also assessed by measuring the amount of hydroxyproline release, indicating collagen degradation by MMPs, after chitosan treatment for 1 or 10 min. Data were collected, tabulated and statistically analysed. Results: Chitosan treatment of acid-etched dentin, before adhesive application, resulted in microtensile bond strength values which are significantly higher (40.7± 1.7 MPa and 37.2±1.9 MPa respectively) and nanoleakage values (56.5±3.8% and 62±3.6 % respectively) that are significantly lower than the untreated control group at 12 mos and 24 mos storage periods (P ≤ 0.05). The stiffness of demineralized dentin increased significantly after 1 min chitosan application (12.6±1.8 MPa) and further increased after 10 min chitosan application (22.4± 2.2 MPa). Hydroxyproline released decreased significantly (P-value <0.001) when completely demineralized dentin was treated with chitosan for 1 min (1.1 µg/mg dentin) with further significant decrease when chitosan was used for 10 min (0.8 µg/mg dentin). Conclusion: Chitosan treatment of acid-etched dentin, before adhesive application, was effective in improving durability of resin-dentin bonded interfaces. Clinical Significance: Despite of the great advances that have occurred in the field of adhesive dentistry, still, biodegradation of resin-dentin bonds over time continues to jeopardize the durability and success of resin composite restorations.

show abstract

“…These natural bio-modifiers have chemical structures that favor their function as antioxidants, cross-linking agents, and inhibitors of MMPs [3,6,[10][11][12][13]. Collagen cross-linking after etching improves the mechanical properties of dentin and enhances resistance to proteolytic degradation [6,7]. It has been found to improve the durability of resin dentin bonds through the formation of intra-and inter-molecular cross-links [8,10,14].…”

Section: Introductionmentioning

confidence: 99%

Effect of Curcumin Suspension and Vitamin C on Dentin Shear Bond Strength and Durability. A Pilot Study

Abuelenain¹,

Neel²,

Abuhaimed³

et al. 2021

TODENTJ

View full text Add to dashboard Cite

Background: Preserving the strength and durability of dentin bonds is a concern of dental researchers and practitioners. Objective: The aim of this study was to investigate the effect of treating etched dentin with vitamin C and curcumin suspension as cross-linking agents on the shear bond strength and durability of a universal dental adhesive. Methods: Extracted human third molar teeth were collected. Fifty-six flat coronal dentin surfaces were divided equally into four groups: (1) treated with adhesives; (2) etched with 37% H3PO4 for 10s before application of adhesives; (3) same as group (2), but with dentin treated with 2.5% curcumin suspension for 60s before the application of adhesive; and (4) same as group (3), but with the use of a 20% vitamin C suspension instead of a curcumin suspension. Filtek Z350XT composite was built for all samples. Half of the samples in each group were subjected to thermocycling. Shear bond strength was measured using a universal testing machine. Scanning electron microscopy was used to investigate the dentinal surfaces after treatment. Results: Treatment with curcumin suspension preserved immediate and long-term bond strength. Conversely, treatment of etched dentin with vitamin C solution significantly reduced the immediate bond strength, but a significant improvement was observed after aging. SEM showed that both cross-linking agents resulted in narrowing or closing of the dentinal tubules, with an adhesive mode of failure. Conclusion: The application of curcumin or vitamin C suspension to acid-etched dentin resulted in different effects on immediate and long-term shear bond strength when using universal adhesives.

show abstract

Role of dentin cross-linking agents in optimizing dentin bond durability

Cited by 10 publications

References 48 publications

Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis

Effect of Collagen Crosslinkers on Dentin Bond Strength of Adhesive Systems: A Systematic Review and Meta-Analysis

Effect of chitosan on resin-dentin interface durability: A 2 year in-vitro study

Effect of Curcumin Suspension and Vitamin C on Dentin Shear Bond Strength and Durability. A Pilot Study

Contact Info

Product

Resources

About