Role of densin‐180 in mouse ventral hippocampal neurons in 24‐hr retention of contextual fear conditioning

Kim, Chong-Hyun; Kim, None Seoyul; Kim, Suhyun; Roh, None Jongtae; Jin, Harin; Song, Bokyung

doi:10.1002/brb3.1891

Cited by 2 publications

(2 citation statements)

References 118 publications

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“…For example, the dorsal hippocampus is vital for spatial learning, and is particularly critical in mediating contextual discrimination (Fanselow & Dong, 2010;Wells et al, 2011). However, the ventral hippocampus is strongly associated with negative affective symptoms (Felix-Ortiz et al, 2013;Jimenez et al, 2020;Kaouane et al, 2020;Kim et al, 2020;Pinizzotto et al, 2020;Ponce-Lina et al, 2020). Similar functional differences along the septo-temporal axis of the hippocampus have been noted in humans, with ventral hippocampus demonstrating greater activity in response to negative affective symptoms (Lau et al, 2010;Strange et al, 2014).…”

Section: Introductionmentioning

confidence: 89%

Isoxazole‐9 reduces enhanced fear responses and retrieval in ethanol‐dependent male rats

Staples

Herman

Lockner

et al. 2021

J of Neuroscience Research

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Plasticity in the dentate gyrus (DG) is strongly influenced by ethanol, and ethanol experience alters long-term memory consolidation dependent on the DG. However, it is unclear if DG plasticity plays a role in dysregulation of long-term memory consolidation during abstinence from chronic ethanol experience. Outbred male Wistar rats experienced 7 weeks of chronic intermittent ethanol vapor exposure (CIE). Seventytwo hours after CIE cessation, CIE and age-matched ethanol-naïve Air controls experienced auditory trace fear conditioning (TFC). Rats were tested for cue-mediated retrieval in the fear context either twenty-four hours (24 hr), ten days (10 days), or twenty-one days (21 days) later. CIE rats showed enhanced freezing behavior during TFC acquisition compared to Air rats. Air rats showed significant fear retrieval, and this behavior did not differ at the three time points. In CIE rats, fear retrieval increased over time during abstinence, indicating an incubation in fear responses.Enhanced retrieval at 21 days was associated with reduced structural and functional plasticity of ventral granule cell neurons (GCNs) and reduced expression of synaptic proteins important for neuronal plasticity. Systemic treatment with the drug Isoxazole-9 (Isx-9; small molecule that stimulates DG plasticity) during the last week and a half of CIE blocked altered acquisition and retrieval of fear memories in CIE rats during abstinence. Concurrently, Isx-9 modulated the structural and functional plasticity of ventral GCNs and the expression of synaptic proteins in the ventral DG.These findings identify that abstinence-induced disruption of fear memory consolidation occurs via altered plasticity within the ventral DG, and that Isx-9 prevented these effects.

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Section: Introductionmentioning

confidence: 89%

Isoxazole‐9 reduces enhanced fear responses and retrieval in ethanol‐dependent male rats

Staples

Herman

Lockner

et al. 2021

J of Neuroscience Research

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“…LRRC7, the host gene of circLRRC7, is a major component of the post-synaptic density (PSD) of excitatory synapses ( Liu et al, 2013 ), and is reported to be associated with memory formation ( Kim et al, 2020 ). We did not detect significantly altered LRRC7 expression in GBM relative to normal brain tissues in the Gliovis database.…”

Section: Discussionmentioning

confidence: 99%

CircularLRRC7 is a Potential Tumor Suppressor Associated With miR-1281 and PDXP Expression in Glioblastoma

Kong

Wang

et al. 2021

Front. Mol. Biosci.

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Circular RNAs (circRNAs) are usually enriched in neural tissues, yet about 80% circRNAs have lower expression in gliomas relative to normal brains, highlighting the importance of circRNAs as tumor suppressors. However, the clinical impact as well as the pathways regulated by the tumor-suppressive circRNAs remain largely unknown in glioblastoma (GBM). Through bioinformatic analysis followed by experimental validation, we found that hsa_circ_0114014 (circLRRC7) was dramatically down-regulated in GBM when compared with normal brain tissues (p < 0.0001). GBM patients with a lower circLRRC7 expression had poorer progression-free survival (PFS, p < 0.05) and overall survival (OS, p < 0.05). Analyses of the predicted target miRNAs of circLRRC7 in CSCD and CRI databases, in combination with the miRNA expression data in GBMs and normal brains from GSE database, revealed miR-1281 as a potential downstream target of circLRRC7. Subsequently, the target genes of hsa-mir-1281 were predicted by TargetScan, miRDB and miRNATAR databases. Intersection analysis and correlation test indicated that PDXP was a potential target of miR-1281. In summary, circLRRC7 may be a tumor suppressor that associated with miR-1281 and PDXP expression in GBM, which may provide novel therapeutic targets for GBM treatment.

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Role of densin‐180 in mouse ventral hippocampal neurons in 24‐hr retention of contextual fear conditioning

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 2 publications

References 118 publications

Isoxazole‐9 reduces enhanced fear responses and retrieval in ethanol‐dependent male rats

Isoxazole‐9 reduces enhanced fear responses and retrieval in ethanol‐dependent male rats

CircularLRRC7 is a Potential Tumor Suppressor Associated With miR-1281 and PDXP Expression in Glioblastoma

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