Role of dendritic cells in the host response to biomaterials and their signaling pathways

Zhu, Fujun; Tong, Yalin; Zhang, Sheng; Yao, Yong‐Ming

doi:10.1016/j.actbio.2019.05.038

Cited by 40 publications

(37 citation statements)

References 121 publications

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“…For instance, Zn was shown to influence the tolerogenic potential of DCs in vitro and in vivo . 26 As discussed in a recently published review paper, 27 the present study is relevant for BG applications because the immune system is involved in any regeneration process in humans and therefore the influence of BGs on the immune system needs to be considered. In addition, the BG compositions were investigated for their antibacterial effects since the immune system plays an important role in bacterial infections.…”

Section: Introductionmentioning

confidence: 98%

Cu, Zn doped borate bioactive glasses: antibacterial efficacy and dose-dependentin vitromodulation of murine dendritic cells

et al. 2020

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Section: Introductionmentioning

confidence: 98%

Cu, Zn doped borate bioactive glasses: antibacterial efficacy and dose-dependentin vitromodulation of murine dendritic cells

et al. 2020

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“…(C.II) At the same time, this process together with the released cytokines leads to the presentation of bacterial antigens as well as cancer specific antigens, to the adaptive immune system leading to the production of cancer-antigen specific T-cells that can recognize and kill the cancer cells as well as the bacteria ( 34 ). An immunological synapse occurs between the bacteria, the cancer cells and the host dendritic cells leading to cross-presentation of tumor antigens, resulting in an antigen-specific anti-cancer immune response ( 35 , 36 ). (C.III) Salmonella bacteria have the potential to directly cause cancer cell death through induction of apoptosis or pyroptosis.…”

Section: Salmonella Bacteria and Treatment Of Cancermentioning

confidence: 99%

Use of Salmonella Bacteria in Cancer Therapy: Direct, Drug Delivery and Combination Approaches

et al. 2021

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Over the years, conventional cancer treatments, such as chemotherapy with only a limited specificity for tumors, have undergone significant improvement. Moreover, newer therapies such as immunotherapy have undergone a revolution to stimulate the innate as well as adaptive immune responses against the tumor. However, it has been found that tumors can be selectively colonized by certain bacteria, where they can proliferate, and exert direct oncolytic effects as well as stimulating the immune system. Bacterial-mediated cancer therapy (BMCT) is now one example of a hot topic in the antitumor field. Salmonella typhimurium is a Gram-negative species that generally causes self-limiting gastroenteritis in humans. This species has been designed and engineered in order to be used in cancer-targeted therapeutics. S. typhimurium can be used in combination with other treatments such as chemotherapy or radiotherapy for synergistic modification of the tumor microenvironment. Considerable benefits have been shown by using engineered attenuated strains for the diagnosis and treatment of tumors. Some of these treatment approaches have received FDA approval for early-phase clinical trials. This review summarizes the use of Salmonella bacteria for cancer therapy, which could pave the way towards routine clinical application. The benefits of this therapy include an automatic self-targeting ability, and the possibility of genetic manipulation to produce newly engineered attenuated strains. Nevertheless, Salmonella-mediated anticancer therapy has not yet been clinically established, and requires more research before its use in cancer treatment.

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“…Therefore, tolDCs are not able to induce sufficient signal to activate T cells. In recent years, tolDCs have been attracting the researchers' interests as a therapeutic target in biomaterials implantation, reducing the transplantation rejection, and autoimmune disease 16,17 . Piemonti et al consumed 1,25(OH) 2 D3 (vitD3) to generate tolDCs.…”

Section: Introductionmentioning

confidence: 99%

10‐hydroxy‐2‐decenoic acid a bio‐immunomodulator in tissue engineering; generates tolerogenic dendritic cells by blocking the toll‐like receptor4

Eslami-Kaliji

Sarafbidabad

Kiani-Esfahani

et al. 2021

J Biomedical Materials Res

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Dendritic cells (DCs), in response to the biomaterials, utilize toll‐like receptors (TLRs) to become mature or tolerogenic through TLRs‐dependent signaling pathways, especially TLR4. Regarding the physicochemical properties of biomaterials, some of such signaling pathways are activated. Unsaturated fatty acids have been explored as an antagonist for TLRs and lead to the tolerogenic phenotype of DCs. Here we showed that, although cultured DCs on both chitosan and Alginate‐polyethyleneimine (Alg‐PEI) films became fully mature, 10‐hydroxy‐2‐decanoic acid (10‐HDA), an unsaturated fatty acid found in royal jelly, led to the tolerogenic immunophenotype of DCs on both films. The cultured cells on the films possessed iDCs‐like morphology in the presence of 10‐HDA. Moreover, 10‐HDA expressed lower levels of CD80, CD83, CD86, and HLA‐DR, a higher level of IL‐10, and lower level of IL‐12 in the cultured DCs on both films. Furthermore, HEK293T cells expressing only TLR4 (HEK‐TLR4 cells) were co‐cultured with LPS, a specific agonist for TLR4, and 10‐HDA. The 10‐HDA significantly reduced the expression of tumor necrosis factor‐a (TNF‐α) in the HEK‐TLR4 cells compared to treated only with LPS. These findings indicate that the 10‐HDA acts as an antagonist of TLR4; therefore, potentially can be used in autoimmune diseases and preventing the rejection of biomaterials implantation and allograft transplantation.

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Role of dendritic cells in the host response to biomaterials and their signaling pathways

Cited by 40 publications

References 121 publications

Cu, Zn doped borate bioactive glasses: antibacterial efficacy and dose-dependentin vitromodulation of murine dendritic cells

Cu, Zn doped borate bioactive glasses: antibacterial efficacy and dose-dependentin vitromodulation of murine dendritic cells

Use of Salmonella Bacteria in Cancer Therapy: Direct, Drug Delivery and Combination Approaches

10‐hydroxy‐2‐decenoic acid a bio‐immunomodulator in tissue engineering; generates tolerogenic dendritic cells by blocking the toll‐like receptor4

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