Role of Daucus carota in Enhancing Antiulcer Profile of Pantoprazole in Experimental Animals

Abstract

The carrot plant (Daucus carota) and its components are traditionally reported for the management of gastric ulcers. This study was performed to evaluate the role of carrot when administered concurrently with a conventional antiulcer treatment, pantoprazole, in alleviating gastric and duodenal ulcers in female experimental animals. The study involved standard animal models to determine the ulcer preventive effect using pylorus ligation, ethanol, and stress induced acute gastric ulcer models and duodenal ulcer models involving cysteamine. Acetic acid-induced chronic gastric ulcer and indomethacin-induced gastric ulcer models were used to evaluate the ulcer healing effect. Carrot fruit (500 mg/kg) and its co-administration with pantoprazole produced significant protection in an ethanol- and stress-induced acute gastric ulcer and cysteamine-induced duodenal ulcer. The healing of the acetic acid-induced chronic gastric ulcer was also augmented with this combination. Both total proteins and mucin contents were significantly increased in indomethacin-induced gastric ulcers. Similarly, in pylorus ligation, the pepsin content of gastric juice, total acidity, and free acidity were reduced. Overall, both ulcer preventive effects and ulcer healing properties of the pantoprazole were significantly enhanced in animals who received the co-administration of carrot fruit (500 mg/kg).

Aqueous extract of Daucus carota exerts a protective effect on the Renal, Hepatic and Duodenal mucosal histology in Diclofenac Induced Tissue Injury

“…Currently, millions of people in the developing world rely on traditional medicinal plants for primary healthcare, skin care, economic benefits, and cultural development (1). Daucus carota (DC), commonly known as carrot, is a popular medicinal plant with several pharmacological activities mentioned in traditional and contemporary phytotherapy including antidiabetic (3,4), antioxidant (5,6,7), analgesic (8), a n t i m i c r o b i a l , a n t i -i n f l a m m a t o r y ( 8 ) , antihyperlipidemic (7), antifungal, diuretic, lithontripic, e m m e n a g o g u e , i n t r a o c c u l a r h y p o t e n s i v e , gastroprotective, hepatoprotective (9), aphrodistic, nephroprotective, has anti-calcifying effect in urolithiasis (10), antispasmodic, anticancer, anti-ulcer (11), adverse effect on sperm activities and sperm morphology (12), antiestrogenic (13), oestrogenic (14), cardioprotective and muscular contraction regulation effects (15), can improve antioxidant status by inhibiting peroxidation activity in liver tissue (16) and wound healing activities. No serious adverse events have been recorded after ingestion of carrot except for some cases of photosensitivity (13).…”

Pantoprazole Attenuates MAPK (ERK1/2, JNK, p38)–NF-κB and Apoptosis Signaling Pathways after Renal Ischemia/Reperfusion Injury in Rats

“…It was shown that it is also useful in avoiding rebleeding of ulcers, and it also has antioxidant activity by lowering calcium overload [25]. PTZ has a sulphoxide group that can scavenge hydroxyl radicals and protect cardiac cells through destruction of ROS by suppressing NADPH oxidase activity [26,27].…”

Potential benefits of gallic acid as skeletal muscle relaxant in animal experimental models

“…As a result, it is critical to support reputable research into developing a muscle relaxant that is free of misuse and other undesirable consequences associated with current muscle relaxants, as well as having high efficacy in reducing muscular pain and other neuromuscular abnormalities ( Soprano et al, 2020 ). A number of recent studies have investigated the use of natural substances to treat a variety of diseases ( Asdaq et al, 2020 ). The presence of phytoconstituents in medicinal plants makes them extremely beneficial to human health.…”