Role of Daptomycin in Cutaneous Wound Healing: A Narrative Review

Abstract

Daptomycin is active against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and the on-label indications for its use include complicated skin and skin structure infections (cSSSI). We performed a narrative review of the literature with the aim to evaluate the role of daptomycin in the skin wound healing process, proposing our point of view on the possible association with other molecules that could improve the skin healing process. Daptomycin may improve wound healing in MRSA-infected burns, surgical wounds, and diabetic feet, but further studies in humans with histological examination are needed. In the future, the combination of daptomycin with other molecules with synergistic action, such as vitamin E and derivates, IB-367, RNA III-inhibiting peptide (RIP), and palladium nanoflowers, may help to improve wound healing and overcome forms of antibiotic resistance.

Smart Hydrogels for Tissue Regeneration

“…[ 163 ] After skin injury, intravascular platelets become activated and secrete a series of growth factors that act as chemoattractants for neutrophils and monocytes. [ 164 ] During the inflammatory phase, these cells differentiate into macrophages, releasing cytokines such as vascular endothelial growth factor (VEGF)‐A, fibroblast growth factors (FGFs), and angiogenin, to stimulate fibroblast migration and activate microvascular endothelial cells (ECs), and subsequently leading to the invasion of angiogenic capillary sprouts into fibrin/fibronectin‐rich wound clots. [ 165 ] This process is facilitated by the dynamic interplay between ECs, angiogenic cytokines, and the ECM produced by fibroblasts, ultimately resulting in the formation of a microvascular network.…”

Update on the Management of Surgical Site Infections

“…Daptomycin could be very useful in the management of surgical site infections, given its pharmacokinetic characteristics, but further human studies with a histological examination are needed. [ 45 , 46 ]. Most associations of Daptomycin with other antimicrobials, especially with beta-lactams or Fosfomycin, show a synergistic or additive activity [ 46 , 47 ].…”

Our Experience over 20 Years: Antimicrobial Peptides against Gram Positives, Gram Negatives, and Fungi

“…Daptomycin is a bactericidal lipopeptide antibiotic widely used to treat systemic infections caused by Gram-positive cocci [ 54 ]. In a study conducted by Simonetti et al (2017), a mouse model was used to study the in vivo efficacy of daptomycin in the treatment of burn wound infections caused by S. aureus and evaluate the wound healing process through morphological and immunohistochemical analysis, compared to teicoplanin.…”