Role of Cytological Grading in Breast Cancer Prognosis and its Histo-pathological Correlation

Mustaphi, None Ruplekha Mitra; Chowdhury, Dr. Surupa; Mondal, Seema; Bhattacharya, Sugata Kumar; Sarkar, Sanjay; Saha, Tushar Kanti

doi:10.9790/0853-13105106109

Cited by 1 publication

(2 citation statements)

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“…Singh et al showed that a better concordance between these grading systems can be achieved by examining 8 cell clusters. [14] Multiple regression analysis of various cytological features was used to assess the significance of each cytological parameter in the past. The coefficient of regression for all the parameters used in Robinson's grading were statistically significant (p=0.000) and all of them equally contributed in determining the cytological grading of the tumour.…”

Section: Discussionmentioning

confidence: 99%

“…Robinson's grading system included the following criteria: Cell dissociation (clusters/single cells),Cell size (1-2/3-4/>5xRBC size), Cell uniformity (monomorphic/ mildly pleomorphic/ pleomorphic), nucleoli(indistitinct/ noticeable/prominent), nuclear chromatin (vesicular/ granular/clumped or cleaved) and nuclear margins (smooth/folds/buds or tufts).Each of the above criteria was given scores 1-3 and total sum of scores of all criteria were used to grade the tumours. Based on this, carcinoma breast cases were graded into grade I (score 6-11), grade II (score [12][13][14] and grade III (score 15-18) respectively. [1] Surgical specimens received for histopathological examination were fixed in 10% formalin.…”

Section: Methodsmentioning

confidence: 99%

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Role of Cytological Grading in Prognostication of Breast Carcinoma

Masamatti¹,

Vijaya

2018

APALM

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Background: Breast carcinoma is now one of the most common cause of death in females worldwide, hence should be early diagnosis and treatment is necessary. This study aims at establishing Fine needle aspiration cytology (FNAC) as an individual parameter in diagnosing and grading breast carcinoma followed by correlation with histological grading. Methods: Cytological smears of 51 cases of breast carcinomas were graded by using Robinson's method and corresponding histology sections were graded according to Elston and Ellis Nottingham modification of Bloom Richardson's method and correlation was done. Result: On cytology, there were 10,26 and 15 cases of grade I, grade II and grade III tumours respectively while on histology there were 12, 31 and 8 cases of grade I, grade II and grade III tumours. The concordance rates between cytology and histology grades were 90%, 76.92% and 26.67% respectively with an absolute concordance rate of 64.71%. Conclusion: FNAC is simple, non invasive and a very good tool which provides information about the aggressiveness of the tumour and helps to select appropriate treatment.

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Section: Discussionmentioning

confidence: 99%