Role of Cystatin-C in assessing the cardiovascular risk among overweight and obese individuals

Krishna, Deepa; M, Rahul; Suma, MN; Vishwanath, Prashant; Devaki, RN; Sudhir,

doi:10.4103/2278-344x.96414

Cited by 2 publications

(1 citation statement)

References 16 publications

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“…In our study, we have also seen the positive correlation of cystatin C with BMI in Group B plain obese and Group C diabetes obese than Group A diabetes non-obese. These reported studies suggest the role of adipose tissues in increasing the level of cystatin C.[ 25 ] A recent study has shown that cystatin C is significantly associated with the incidence of diabetes in patients having high fat mass. [ 1 ]…”

Section: Discussionmentioning

confidence: 99%

To compare the level of cystatin C in type 2 diabetes mellitus with obesity

Jhatta

Girdhar

Gupta

et al. 2020

Indian J Endocr Metab

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Background: Cystatin C is a non-glycosylated basic protein that is produced and secreted at a constant rate by all nucleated cells. Cystatin C is a more reliable marker than the serum creatinine because it is less affected by external factors such as gender, race and muscle mass. However, the comparison of serum cystatin C level in type 2 diabetes mellitus is not well known in people with obesity. Objectives: To estimate the level of cystatin C in type 2 diabetes and that can be explained by the change in obesity. Thus, this current study aimed to determine and compare the level of cystatin C in type 2 DM with obesity and also correlate the cystatin C level with the quality of life in type 2 DM and obesity. Material and Methods: We have taken three groups: Group A containing type 2 DM, Group B containing obesity, and Group C containing type 2 DM with obesity. In all, 25 patients in each group were selected and analyzed for cystatin C. Results: Cystatin C level was very high in type 2 DM with obesity group. The P value was 0.008 in type 2 DM with the obesity group and it has shown a highly significant correlation with BMI. In our study, we have also seen the positive correlation of cystatin C with BMI in Group B plain obese and Group C diabetes obese than Group A diabetes non-obese. We have seen in our study and found a poor correlation between HbA1c, RBS and cystatin C. Conclusion: The level of cystatin C is much higher in type 2 DM with obese patient as compared with type 2 DM and obese patients.

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Section: Discussionmentioning

confidence: 99%

To compare the level of cystatin C in type 2 diabetes mellitus with obesity

Jhatta

Girdhar

Gupta

et al. 2020

Indian J Endocr Metab

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Urinary Se-Cadherin and Plasma Cystatin C as Novel Biomarkers of Diabetic Nephropathy

Aly

Elantouny

Amr³

et al. 2014

Zagazig University Medical Journal

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Background and aim : Diabetes is a major cause of chronic kidney disease (CKD). Urine albumin and estimated glomerular filtration rate (eGFR) are the two key markers for chronic kidney disease (CKD). The aim of our work was to explore the possibility of plasma cystatin C and urinary sE.cadherin as useful biomarkers for early detection of diabetic nephropathy (DN). Methods:-A total number of 80 subjects were included and were classified into three main groups. Group I (20) normal subjects with no history of DM, hypertension or other diseases and with albumin / creatinine (Alb / Cr) ratio below 30 mg/ g. Group II (30) type 2 diabetic patients with Alb / Cr ratio below 30 mg/ g. Group III (30) type 2 diabetic patients with Alb / Cr ratio between 30 and 300 mg/ g. The latter two groups were divided in two sub groups A and B according to GFR by MDRD: normal (≥ 90 ml /min / 1.73 m2) and < 90 ml /min / 1.73 m2. All subjects underwent urine analysis, complete blood picture, liver function tests, kidney function tests, INR, fasting plasma glucose level, HbA1c, lipid profile, abumin/creatinine ratio, pelvi-abdominal ultrasound, plasma Cystatin C and urinary human sE-Cadherin. Results:-Plasma cystatin C and urinary sE.cadherin/ cr levels were increased with micro-albuminuria. Also, plasma cystatin C and urinary sE.cadherin/ cr levels were significant between normoalbuminuric subjects with GFR ≥ 90 mL/min/1.73 m2 calculated by the MDRD equation and those below 90 mL/min/1.73 m2 being higher in the later. In multivariate logistic analysis, plasma cystatin C level was the only independent factor associated with eGFR < 90 mL/min/1.73m2 estimated by MDRD equation in patients with normoalbuminuria. There are high significant positive correlations of plasma cystatin C with age, total cholesterol unlike urinary sE.cadherin/ cr, but both had positive correlations with serum Cr, blood urea and Alb / Cr ratio and negative correlations with GFR. Conclusion and Recommendations:-Plasma cystatin C and urinary sE.cadherin levels could be useful markers for detection of microalbuminuria and renal impairment in type 2 diabetic patients with normoalbuminuria.

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Role of Cystatin-C in assessing the cardiovascular risk among overweight and obese individuals

Cited by 2 publications

References 16 publications

To compare the level of cystatin C in type 2 diabetes mellitus with obesity

To compare the level of cystatin C in type 2 diabetes mellitus with obesity

Urinary Se-Cadherin and Plasma Cystatin C as Novel Biomarkers of Diabetic Nephropathy

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