Role of CYP2E1 genotypes in susceptibility to colorectal cancer in the Kashmiri population

Sameer, Aga Syed; Nissar, Saniya; Qadri, Qurteeba; Alam, Shafia; Baba, Shahid M.; Siddiqi, Mushtaq A.

doi:10.1186/1479-7364-5-6-530

Cited by 19 publications

(7 citation statements)

References 30 publications

(38 reference statements)

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“…Rsa I polymorphism has been reported to increase susceptibility to colorectal cancer in Kashmir population in India. 24 A study in the Fujian province of China revealed that the presence of c2 allele elevated the risk for gastric cancer, but was found as a protective factor for oesophageal squamous cell cancer in another study in China. 3 5 Besides, Ladero et al 4 who reported that a carrier with one copy of c2 allele increased the risk of hepatocellular carcinoma with the addition of regular alcohol intake in the Spanish, supported the findings by Lee et al 17 in Korean and Japanese populations and by Deka et al 8 in Indian population.…”

Section: Discussionmentioning

confidence: 98%

RsaI but notDraI polymorphism inCYP2E1gene increases the risk of gastrointestinal cancer in Malaysians: a case–control study

et al. 2014

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ObjectivesOur study aimed to investigate the association of CYP2E1 C-1019T RsaI and T7678A DraI polymorphisms and factors such as age, gender and ethnicity to the risk of gastrointestinal cancer (GIC) in Malaysians.DesignCase–control study.SettingMalaysia.Participants520 consented healthy blood donors with no previous GIC record and 175 patients with GIC.MeasurementsC-1019T RsaI and T7678A DraI genotyping of CYP2E1 gene; direct sequencing.ResultsThis study reveals that the variant c2 allele and carrier with at least one c2 allele of C-1019T single nucleotide polymorphism (SNP) significantly increased the risk of GIC but no significant association was found between T7678A SNP and combined analysis of C-1019T and T7678A SNPs to risk of GIC. The Malaysian Chinese had greater risk of GIC compared with the Malays, Indians and KadazanDusun. An increased risk of GIC was observed in individuals aged >40 years and women had a 2.22-fold and 1.58-fold increased risk of stomach and colorectal cancers, respectively, when compared with men.LimitationsThe future research should be conducted with a larger sample population and including the gene–gene and gene–environmental interactions.ConclusionsOur study suggests that the rare c2 allele and carrier with at least one c2 allele of CYP2E1 RsaI polymorphism significantly elevated the risk of GIC and may be used as a genetic biomarker for early screening of GIC in Malaysians. The risk age-group has been shifted to a younger age at 40s and women showed a significant greater risk of stomach and colorectal cancers than men.

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Section: Discussionmentioning

confidence: 98%

RsaI but notDraI polymorphism inCYP2E1gene increases the risk of gastrointestinal cancer in Malaysians: a case–control study

et al. 2014

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“… 29 ✭ ✭ ✭ ✭ ✭ ✭ ✭ 7 Sameer et al . 27 ✭ ✭ ✭ ✭✭ ✭ ✭ ✭ 8 Silva et al . 14 ✭ ✭ ✭ ✭ ✭ 5 Saeed et al 19 ✭ ✭ ✭ ✭✭ ✭ 6 Chong et al .…”

Section: Resultsunclassified

“…Of the included studies, two were in Chinese 22,23 and the rest were in English. Seven studies were conducted on Asians 17,[22][23][24][25][26][27] , seven studies were conducted on Caucasians 11,[13][14][15][16]28,29 , and the remaining four studies included participants of other descendants 8,18,19,30 . The most commonly used method for genotyping the polymorphisms was polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), while a few studies used Taqman or microarray-based approaches.…”

Section: Resultsmentioning

confidence: 99%

Association between CYP2E1 polymorphisms and colorectal cancer risk: a systematic review and meta-analysis

Sharzehan

Sito

Abdullah

et al. 2022

Sci Rep

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CYP2E1 encodes an enzyme that participates in the activation of several carcinogenic substances. Thus, numerous studies have investigated the association between CYP2E1 polymorphisms and colorectal cancer (CRC) risk, but inconclusive results have been obtained. We performed a meta-analysis to precisely evaluate the relationship of CYP2E1 rs2031920, rs3813867, and rs6413432 polymorphisms with the susceptibility to CRC. Scopus, Web of Science and PubMed databases were searched to identify eligible studies, and the association between the polymorphisms and CRC risk was then quantitatively synthesized using different genetic models. Eighteen studies with 23,598 subjects were selected for inclusion into the analysis. Significant association between rs2031920 and an increased CRC risk was observed in homozygous (OR = 1.496, 95% CI 1.177–1.901, P = 0.001), recessive (OR = 1.467, 95% CI 1.160–1.857, P = 0.001) and allele (OR = 1.162, 95% CI 1.001–1.349, P = 0.048) models. Significant association was not found for rs3813867 and rs6413432 (P > 0.05). In conclusion, our results suggest that rs2031920, but not rs3813867 and rs6413432, is associated with the risk of CRC.

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“…There was a single study from Mumbai; Maharashtra reported significant association of CYP2D6 with head and neck cancer (Shukla et al, 2012). Similarly polymorphism in CYP2E1 isoforms was also illustrated in colorectal cancer risk in Kashmiri population (Sameer et al, 2011), gastric cancer risk in West Bengal population (Ghosh et al, 2017) and head and neck cancer risk in North Indian population (Gupta et al, 2014). However, other studies reported no contribution of CYP2E1 gene polymorphism with oral cancer susceptibility in South Indians (Balaji et al, 2011).…”

Section: Introductionmentioning

confidence: 95%

CYP2D6 and CYP2E1 Gene Polymorphisms and their Association with Cervical Cancer Susceptibility: A Hospital Based Case-Control Study from South-Western Maharashtra

Datkhile

Durgawale

Gudur

et al. 2022

Asian Pac J Cancer Prev

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Background: In last few years several studies all over the world discovered the genetic polymorphisms in different cytochrome P450 genes associated with risk of various cancers, but contradictory outcomes were evidenced in case of cervical cancer risk. In this case-control study we aimed to see whether the polymorphism of CYP2D6 or CYP2E1 genes may or may not be associated with cervical cancer risk in women of rural Maharashtra. Methods: In this case-control study, the association of CYP2D6 and CYP2E1 gene polymorphism with cervical cancer risk was studied by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The study was conducted with 350 clinically confirmed cervical cancer patients and 350 healthy women in a population of South-Western Maharashtra. The Odds ratio (OR) with 95% confidence interval and p-value were evaluated, where p ≤0.005 was considered as statistically significant. Results: After the analysis of SNP (rs389209) of CYP2D6 and SNPs (rs2031920, rs6413432, rs6413420) of CYP2E1, we noticed that variant allele A of CYP2E1*6 showed significant increase in cervical cancer cases (OR=4.81; 95% CI: 1.57-14.77; p=0.005). The genotypic distribution of heterozygote G/A genotype of CYP2D6*4 showed negative association with cervical cancer development when age of cancer occurrence (OR=0.41; 95% CI: 0.27-0.61; p<0.0001) and tobacco history (OR=0.35; 95% CI: 0.20-0.59; p=0.0001) was considered. Conclusion:The findings from this study supported that rs6413432 SNP of CYP2E1*6 increased cervical cancer risk in the studied rural women population.

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Role of CYP2E1 genotypes in susceptibility to colorectal cancer in the Kashmiri population

Cited by 19 publications

References 30 publications

RsaI but notDraI polymorphism inCYP2E1gene increases the risk of gastrointestinal cancer in Malaysians: a case–control study

RsaI but notDraI polymorphism inCYP2E1gene increases the risk of gastrointestinal cancer in Malaysians: a case–control study

Association between CYP2E1 polymorphisms and colorectal cancer risk: a systematic review and meta-analysis

CYP2D6 and CYP2E1 Gene Polymorphisms and their Association with Cervical Cancer Susceptibility: A Hospital Based Case-Control Study from South-Western Maharashtra

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