Role of curcumin and its nanoformulations in the treatment of neurological diseases through the effects on stem cells

Sabouni, Nasim; Marzouni, Hadi Zare; Palizban, Sepideh; Meidaninikjeh, Sepideh; Kesharwani, Prashant; Jamialahmadi, Tannaz; Sahebkar, Amirhossein

doi:10.1080/1061186x.2022.2141755

Cited by 11 publications

(7 citation statements)

References 208 publications

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“…Curcumin is a kind of yellow small molecule plant polyphenol extracted from the rhizome of turmeric, Curcuma, turmeric, etc. Numerous studies have provided experimental evidence for curcumin in the treatment and prevention of neurological diseases [ 86 ]. Curcumin can promote a series of neuroprotective responses by regulating various signal cascades in the brain, such as improving neuronal vitality, promoting neuronal differentiation and inhibiting neuronal apoptosis [ 87 ].…”

Section: Potential Mechanisms Of Traditional Chinese Medicine Natural...mentioning

confidence: 99%

A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory

Chen,

Wang,

et al. 2024

Chin Med

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Alzheimer’s disease (AD) is a neurodegenerative disease with insidious onset and progressive development. It is clinically characterized by cognitive impairment, memory impairment and behavioral change. Chinese herbal medicine and acupuncture are important components of traditional Chinese medicine (TCM), and are commonly used in clinical treatment of AD. This paper systematically summarizes the research progress of traditional Chinese medicine natural products and acupuncture treatment of AD, which combined with existing clinical and preclinical evidence, based on a comprehensive review of neuroinflammation, and discusses the efficacy and potential mechanisms of traditional Chinese medicine natural products and acupuncture treatment of AD. Resveratrol, curcumin, kaempferol and other Chinese herbal medicine components can significantly inhibit the neuroinflammation of AD in vivo and in vitro, and are candidates for the treatment of AD. Acupuncture can alleviate the memory and cognitive impairment of AD by improving neuroinflammation, synaptic plasticity, nerve cell apoptosis and reducing the production and aggregation of amyloid β protein (Aβ) in the brain. It has the characteristics of early, safe, effective and benign bidirectional adjustment. The purpose of this paper is to provide a basis for improving the clinical strategies of TCM for the treatment of AD. Graphical Abstract

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Section: Potential Mechanisms Of Traditional Chinese Medicine Natural...mentioning

confidence: 99%

A review on traditional Chinese medicine natural products and acupuncture intervention for Alzheimer’s disease based on the neuroinflammatory

Chen,

Wang,

et al. 2024

Chin Med

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“…Curcumin is able to modulate fundamental mechanisms that contribute to neurological disorders, such as oxidative stress, inflammation, apoptosis, and protein aggregation at the molecular level. Therefore, curcumin may be a promising therapeutic molecule to treat NDs and it has been specifically studied for its impact on astrocyte activation and reactive astrogliosis (Daverey & Agrawal, 2018; Sabouni et al, 2022). Curcumin scavenges free radicals (superoxide and hydroxyl ions), retains glutathione, and alleviates oxidative stress (Mandal, Jaiswal, & Mishra, 2020).…”

Section: Phytomedicines In Treating Neurological Disordersmentioning

confidence: 99%

“…Despite the influential role of curcumin in various chronic NDs such as AD, PD, ALS, HD, and multiple sclerosis by aiming at multiple targets, its low bioavailability and quick clearance in the body limits its clinical application. Therefore, many innovative methods, such as nanotechnology/nanoformulations, have been leveraged to enhance the medicinal effects (Sabouni et al, 2022). The nanoformulation of curcumin has been shown to increase its bioavailability in clinical trials (J. Ringman et al, 2008); however, more detailed clinical trials and pharmacokinetic studies of the nanoformulations are required to point to potential applications against NDs in humans.…”

Section: Phytomedicines In Treating Neurological Disordersmentioning

confidence: 99%

Phytomedicine for neurodegenerative diseases: The road ahead

Madhubala,

Patra,

Khan

et al. 2024

Phytotherapy Research

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Neurodegenerative disorders (NDs) are among the most common causes of death across the globe. NDs are characterized by progressive damage to CNS neurons, leading to defects in specific brain functions such as memory, cognition, and movement. The most common NDs are Parkinson's, Alzheimer's, Huntington's, and amyotrophic lateral sclerosis (ALS). Despite extensive research, no therapeutics or medications against NDs have been proven to be effective. The current treatment of NDs involving symptom‐based targeting of the disease pathogenesis has certain limitations, such as drug resistance, adverse side effects, poor blood–brain barrier permeability, and poor bioavailability of drugs. Some studies have shown that plant‐derived natural compounds hold tremendous promise for treating and preventing NDs. Therefore, the primary objective of this review article is to critically analyze the properties and potency of some of the most studied phytomedicines, such as quercetin, curcumin, epigallocatechin gallate (EGCG), apigenin, and cannabinoids, and highlight their advantages and limitations for developing next‐generation alternative treatments against NDs. Further extensive research on pre‐clinical and clinical studies for developing plant‐based drugs against NDs from bench to bedside is warranted.

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“…Another promising example involves the use of curcuminloaded nanoparticles for SCI treatment. Curcumin, a natural polyphenolic compound derived from the turmeric plant, exhibits anti-inflammatory, antioxidant, and neuroprotective properties (Vaiserman et al, 2020;Sabouni et al, 2023), making it a promising candidate for addressing SCI (Krupa et al, 2019). However, the therapeutic efficacy of curcumin is limited by its low bioavailability and poor water solubility.…”

Section: Nanostructured Biomaterials Based Therapymentioning

confidence: 99%