Role of CRS and HIPEC in appendiceal and colorectal malignancies: Indian experience

Gupta, Nikhil; Syed, Kamran Asif; Gandhi, Jatin; Rajpurohit, Sajjan; Singh, Sapna

doi:10.1007/s12664-017-0747-3

Cited by 12 publications

(18 citation statements)

References 10 publications

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“…Thirty-two studies were identified evaluating different techniques for intraperitoneal chemotherapy in CPM (Table 3) [41–72]. Sixteen of those studies looked at drug delivery techniques [41, 42, 44–46, 49, 51, 52, 54, 55, 58–60, 62, 67, 68], and 16 looked at novel pharmacological approaches for drug conveyance and therapeutic enhancement [43, 47, 48, 50, 53, 56, 57, 61, 63–66, 69].…”

Section: Resultsmentioning

confidence: 99%

Colorectal Peritoneal Metastases: A Systematic Review of Current and Emerging Trends in Clinical and Translational Research

Koumpa

Xylas

Konopka

et al. 2019

Gastroenterology Research and Practice

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Colorectal peritoneal metastases (CPM) are associated with abbreviated survival and significantly impaired quality of life. In patients with CPM, radical multimodality treatment consisting of cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has demonstrated oncological superiority over systemic chemotherapy alone. In highly selected patients undergoing CRS + HIPEC, overall survival of over 60% has been reported in some series. These are patients in whom the disease burden is limited and where the diagnosis is made at an early stage in the disease course. Early diagnosis and a deeper understanding of the biological mechanisms that regulate CPM are critical to refining patient selection for radical treatment, personalising therapeutic approaches, enhancing prognostication, and ultimately improving long-term survivorship. In the present study, we outline three broad themes which represent critical future research targets in CPM: (1) enhanced radiological strategies for early detection and staging; (2) identification and validation of translational biomarkers for diagnostic, prognostic, and therapeutic deployment; and (3) development of optimized approaches for surgical cytoreduction as well as more precise strategies for intraperitoneal drug selection and delivery. Herein, we provide a contemporary narrative review of the state of the art in these three areas. A systematic review in accordance with PRISMA guidelines was undertaken on all English language studies published between 2007 and 2017. In vitro and animal model studies were deemed eligible for inclusion in the sections pertaining to biomarkers and therapeutic optimisation, as these areas of research currently remain in the early stages of development. Acquired data were then divided into hierarchical thematic categories (imaging modalities, translational biomarkers (diagnostic/prognostic/therapeutic), and delivery techniques) and subcategories. An interactive sunburst figure is provided for intuitive interrogation of the CPM research landscape.

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Section: Resultsmentioning

confidence: 99%

Colorectal Peritoneal Metastases: A Systematic Review of Current and Emerging Trends in Clinical and Translational Research

Koumpa

Xylas

Konopka

et al. 2019

Gastroenterology Research and Practice

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“…For the purpose of this study, we have retained PMP as a unified diagnosis to allow for more informative statistical analyses. Various studies have shown that survival is improved with low‐grade PMP compared to high‐grade PMP . Nevertheless, the overall management of low‐ and high‐grade PMP remains the same.…”

Section: Discussionmentioning

confidence: 99%

Outcomes from cytoreduction and hyperthermic intraperitoneal chemotherapy for appendiceal epithelial neoplasms

Narasimhan

Pham

Warrier

et al. 2019

ANZ Journal of Surgery

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Background: Appendiceal epithelial neoplasms are rare cancers. Management of peritoneal disease from appendiceal neoplasms has historically been with debulking surgery. In recent decades, the advent of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has become the standard of care. Here, we report our single institution 10-year experience with CRS and HIPEC for appendiceal neoplasms. Methods: This is a retrospective review from 1 January 2008 to 1 June 2017 of all patients undergoing CRS and HIPEC for appendiceal neoplasms. Institutional ethics approval was granted for this project. Results: One hundred and seventy-two patients underwent 208 CRSs during this time. Overall, 83.72% of patients had one CRS and HIPEC procedure. Pseudomyxoma peritonei from a perforated appendiceal mucinous neoplasm accounted for 67.9% of cases. The median peritoneal carcinomatosis index (PCI) was 14, with complete cytoreduction achieved in 74.2% of patients. Fifty-four percent of patients had at least one complication, with one (0.5%) peri-operative mortality in our cohort. For the entire cohort, the median overall survival was 104 months and a 5-year survival of 75%. In those having a complete cytoreduction, 5-year survival was 90%, with a median disease free interval of 63 months. PCI and completeness of cytoreduction were independent predictors of overall survival. Conclusion: Our results demonstrate that CRS and HIPEC for appendiceal neoplasms are safe and effective. Despite carrying some morbidity, it offers patients an excellent disease free and overall survival.

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“…Siendo la tasa de grave morbilidad a los 60 días mayor con CRS/HIPEC que con CRS solo (24.1% vs 13.6%, respectivamente). En contraparte Gupta y otros (61) también compararon la sobrevida de pacientes tratados con CRS/HIPEC cerrada y pacientes tratados únicamente con CRS. Como resultado, la sobrevida a 4 años de la CRS/HIPEC cerrada y la CRS fue de 58.9% y 33.33%, respectivamente.…”

Section: Discussionunclassified

Manejo De La Carcinomatosis Peritoneal De Origen Colorrectal Y Realidad en Panamá

Candanedo¹,

Casiano²,

Castillero³

et al. 2020

Rev Med Cient

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RESUMEN Antecedentes El término carcinomatosis peritoneal fue utilizado por primera vez por Sampson en 1931 para describir la diseminación peritoneal de una neoplasia avanzada de ovario. Hoy el término carcinomatosis peritoneal incluye toda diseminación tumoral, local o masiva, que compromete la serosa peritoneal y las estructuras anatómicas vecinas. Un 30% a 40% de pacientes con carcinoma colorrectal van a desarrollar en algún momento metástasis, es decir 90 pacientes, de hecho la carcinomatosis peritoneal es la segunda presentación más común de la metástasis a distancia del cáncer de colon. Objetivo: Presentar la evidencia publicada sobre el abordaje y tratamiento quirúrgico de la carcinomatosis peritoneal de cáncer colorrectal en otras latitudes e impulsar el estudio, manejo y difusión de los conocimientos de la metástasis peritoneal principalmente a nivel nacional. Diseño: Se utilizaron artículos científicos indexados entre 2010 y 2020, que fueron seleccionados por su relevancia, validez y calidad de contenido, como aquellos disponibles en National Center for Biotechnology Information, Surgical Oncology Clinics of North America, Annals of Surgical Oncology, World Journal of Surgical Oncology obtenidas a través de diversas bibliotecas virtuales. Conclusión: La cirugía citorreductora en combinación con quimioterapia intraperitoneal hipertérmica ha mejorado la sobrevida global a los 5 años de 40 a 51% dando resultados prometedores en pacientes con carcinomatosis peritoneal de origen colorrectal altamente seleccionados e incluso se considera el único tratamiento potencialmente curativo. Palabras claves: carcinomatosis peritoneal, cáncer colorrectal, Cirugía citorreductora (CRS), quimioterapia intraperitoneal hipertérmica (HIPEC).

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Role of CRS and HIPEC in appendiceal and colorectal malignancies: Indian experience

Cited by 12 publications

References 10 publications

Colorectal Peritoneal Metastases: A Systematic Review of Current and Emerging Trends in Clinical and Translational Research

Colorectal Peritoneal Metastases: A Systematic Review of Current and Emerging Trends in Clinical and Translational Research

Outcomes from cytoreduction and hyperthermic intraperitoneal chemotherapy for appendiceal epithelial neoplasms

Manejo De La Carcinomatosis Peritoneal De Origen Colorrectal Y Realidad en Panamá

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