Role of costimulatory molecules on airway epithelial cells acting as alloantigen-presenting cells

Nakajima, Jun; Ono, M.; Takeda, Masatami; Kawauchi, M; Furuse, Akio; Takizawa, Hajime

doi:10.1016/s0041-1345(97)00334-5

Cited by 23 publications

(23 citation statements)

References 13 publications

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“…Consistent with previous reports of the responsiveness of the HLA molecules, and especially HLA-DR, to activation by cytokines at both mRNA and protein levels (17,26,32,33), fully differentiated HNE cells showed significantly increased transcript levels following treatment with IFN-␥ and TNF-␣. In contrast, transcript levels for B7-2 at the 100 ng/ml concentration and for B7-H3 and B7-H2 at three concentrations bracketing the latter remained unchanged by cytokine treatment.…”

Section: Dose-response Characteristics Of B7-h2 and B7-h3 To Treatmensupporting

confidence: 91%

“…Although constitutive expression of this molecule is not consistently detectable on cells from unstimulated sources (49), reports indicate that expression of the class II molecule, human leukocyte antigen (HLA)-DR, is increased on epithelial cells in several airway inflammatory conditions, including on nasal epithelium in allergic rhinitis (33) and on bronchial epithelium in chronic bronchitis (30) and bronchial asthma (2,42). Importantly, treatment of epithelial cells with interferon (IFN)-␥, a cytokine released by lymphocytes and present in varying concentrations in the airways (14), has been demonstrated to significantly increase and sustain expression of HLA-DR on primary bronchial epithelial cells and cell lines (17,26,32,33). Several of these studies offer evidence in allogeneic coculture systems that airway epithelial cells are capable of providing the accessory stimulation required for T cell activation (17,34,49).…”

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confidence: 99%

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Expression of genes for B7-H3 and other T cell ligands by nasal epithelial cells during differentiation and activation

Saatian¹,

Yu²,

Lane³

et al. 2004

American Journal of Physiology-Lung Cellular and Molecular Phys

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Epithelial cells of the human respiratory tract express human leukocyte antigen (HLA) and the costimulatory molecules B7-1 and B7-2. Little is known, however, about the constitutive expression of genes encoding for the more recently identified members of the B7 homolog family of costimulatory molecules or about the influence of cellular differentiation and cytokines on their activity or on that of HLA or B7-1 and B7-2. Human nasal epithelial (HNE) cells were grown at the air-liquid interface (ALI) for 2 or 21 days to model in vivo conditions. Expression of genes for HLA-B and HLA-DR1 increased during mucociliary differentiation during this period and became more similar to HNE cells obtained fresh by brush biopsy from nasal turbinates. Gene transcripts for B7-H3 and B7-H2 were abundantly expressed in cells cultured at the ALI, but neither their activities nor that of B7-2 was significantly altered during differentiation. IFN-gamma and TNF-alpha upregulated mRNA encoding for both HLA molecules, but not for the B7 molecules. This study describes, for the first time, the expression of B7-H3 and B7-H2 by HNE cells and thus expands the range of potential costimulatory signals through which these cells may interact with activated mucosal T lymphocytes. In addition, the results suggest that the extent of mucociliary differentiation of cultured cells may influence this capability

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Section: Dose-response Characteristics Of B7-h2 and B7-h3 To Treatmensupporting

confidence: 91%

mentioning

confidence: 99%

Expression of genes for B7-H3 and other T cell ligands by nasal epithelial cells during differentiation and activation

Saatian¹,

Yu²,

Lane³

et al. 2004

American Journal of Physiology-Lung Cellular and Molecular Phys

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“…Aoki et al (26) reported that a period of 20 days is needed to deplete the epithelium that expressed the major histocompatibility complex (MHC) class II antigen, we therefore chose 2 and 6 weeks preservation period in the present study, to examine the differential effect of intravenous injection of BMSCs on the preserved allograft survival. Cryopreserved allografts have lower allogenicity than fresh allografts, partly because of the exfoliation of airway epithelium that can act as alloantigen-presenting cells (27)(28)(29) and decreased viability of chondrocytes (30). In our study, donor tracheal rings that were cryopreserved for 6 weeks had better survival conditions than those cryopreserved for 2 weeks.…”

Section: Discussionmentioning

confidence: 62%

Bone Marrow-Derived Mesenchymal Stem Cells Enhance Cryopreserved Trachea Allograft Epithelium Regeneration and Vascular Endothelial Growth Factor Expression

ChaoJian

Tong

2011

Transplantation

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“…In the airways, there exist a number of dendritic cells, which have a potent ability of antigen presentation [71]. Besides, BEC themselves have a capacity to express ICAM-1 (CD54), B7, and LFA-3, as well as HLA class II antigens [72]. Therefore, it is quite probable that BEC play an important role in the mucosal immunity of the airways.…”

Section: Role Of Bec In Airway Mucosal Immunitymentioning

confidence: 99%

“…Increased levels of ICAM-1 mRNA have been shown as assessed by northern blot analysis. Flow cytometric analysis indicated that B7-1 and LFA-3 were expressed without stimulation [72]. We further studied the effect of a variety of co-stimulatory molecules on lymphocyte proliferation.…”

Section: Role Of Bec In Airway Mucosal Immunitymentioning

confidence: 99%

Bronchial Epithelial Cells in Allergic Reactions

Takizawa

2005

CDTIA

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Bronchial epithelial cells (BEC) are known to play an integral role in the airway defense mechanism via mucociliary system as well as mechanical barriers. Recent studies further indicate that BEC produce and release biologically active compounds including lipid mediators, growth factors, endothelin and a variety of cytokines/chemokines important in the pathogenesis of airway disorders. Cytokines and chemokines produced by BEC include IL-6, IL-8, G-CSF, GM-CSF, RANTES, eotaxin and TARC. Pro-inflammatory cytokines IL-1 and TNF-alpha, generally upregulate expression and release these cytokines/chemokines. BEC from patients with bronchial asthma showed increased levels of mRNA for these potent inflammatory peptides. BEC also interact with immune and inflammatory cells by direct adhesion as well as by humoral factors including cytokines. For example, eosinophil adhesion to BEC may be an important signal for the activation and degranulation of eosinophils. BEC is also believed to take part in the airway mucosal immunity via Toll-like receptors. Finally, BEC may play a crucial role in the processes of airway remodeling by cross-talk with mesenchymal cells. These findings strongly suggest that BEC are actively involved as regulators of allergic inflammatory responses, and become a target for therapeutic intervention.

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Role of costimulatory molecules on airway epithelial cells acting as alloantigen-presenting cells

Cited by 23 publications

References 13 publications

Expression of genes for B7-H3 and other T cell ligands by nasal epithelial cells during differentiation and activation

Expression of genes for B7-H3 and other T cell ligands by nasal epithelial cells during differentiation and activation

Bone Marrow-Derived Mesenchymal Stem Cells Enhance Cryopreserved Trachea Allograft Epithelium Regeneration and Vascular Endothelial Growth Factor Expression

Bronchial Epithelial Cells in Allergic Reactions

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