Role of corticotropin-releasing factor on bladder function in rats with psychological stress

Seki, Mitsunori; Xm, Zha; Ito, Hajime; Aoki, Y.; Matsuta, Yosuke; Taga, Michiyoshi; Inamura, Shogo; Yokoyama, Osamu

doi:10.1016/s1569-9056(19)30518-4

Cited by 4 publications

(5 citation statements)

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“…Future clinical trials should focus on exploring the effectiveness of CRH1 antagonists, specifically antalarmin and NBI-27914, in reducing GI symptoms, improving long-term disease outcomes, and comparing these drugs' advantages over current treatments for IBD and IBS. There are few preclinical studies of CRHR1 antagonists treating endometriosis and bladder disorders; therefore, additional studies must be done before these drugs reach clinical trials for these diseases such as the studies included in this review that demonstrated positive results [25,27,50]. Current evidence in this review supports that there is still hope for CRH-R1 antagonists to reveal their potential as emerging treatments for abdominal and pelvic chronic diseases.…”

Section: Clinical Relevance and Recommendationsmentioning

confidence: 72%

“…Similarly, Buckely et al used an open field to induce psychological stress where coadministration of the monoclonal IL-6 receptor with antalarmin synergistically decreased FPO and pain threshold to colorectal distention [47]. On the other hand, three studies used footshock as a model to induce stress where Funatsu et al observed decreased defecation and freezing behavior by α-helical CRH 9-41, Robbins et al, observed that administration of antisauvagine 30 but not antalarmin decreased bladder hypersensitivity and Seki et al, observed that antalarmin partially prevented muscarinic contractions [48][49][50]. Finally, conditioning fear stress was used by Itomi et al where oral pretreatment with T-3047928 (CRH-R1 antagonist) suppressed the increase in FPO [51].…”

Section: Plos Onementioning

confidence: 99%

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Beyond depression and anxiety; a systematic review about the role of corticotropin-releasing hormone antagonists in diseases of the pelvic and abdominal organs

et al. 2022

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Evidence for beneficial effects of corticotropin releasing hormone (CRH) antagonists in abdominal and pelvic organs is emerging in preclinical studies. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement a compilation of preclinical studies using CRH receptor antagonists as a treatment for abdominal and pelvic disease was carried out. The Animal Research: Reporting of In Vivo Experiments (ARRIVE) essential 10 guidelines were used to determine quality of the included studies. A total of 40 studies from the last 15 years studying irritable bowel syndrome, inflammatory bowel disease, endometriosis, enteritis, stress impact on gastrointestinal processes and exogenous CRH administration effects were included. Blockage of the CRH receptor 1 was mainly associated with beneficial effects while that of CRH receptor 2 worsened studied effects. However, time of administration, route of administration and the animal model used, all had an impact on the beneficial outcomes. Frequency of drugs administered indicated that astressin-2B, astressin and antalarmin were among the most utilized antagonists. Of concern, studies included were predominantly carried out in male models only, representing a gender discrepancy in preclinical studies compared to the clinical scenario. The ARRIVE score average was 13 with ~60% of the studies failing to randomize or blind the experimental units. Despite the failure to date of the CRH antagonists in moving across the clinical trials pipeline, there is evidence for their beneficial effects beyond mood disorders. Future pre-clinical studies should be tailored towards effectively predicting the clinical scenario, including reduction of bias and randomization.

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Section: Clinical Relevance and Recommendationsmentioning

confidence: 72%

Section: Plos Onementioning

confidence: 99%

Beyond depression and anxiety; a systematic review about the role of corticotropin-releasing hormone antagonists in diseases of the pelvic and abdominal organs

et al. 2022

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“…Beside the above genes, several G proteins have also been noticed. e abnormal secretion of intercellular transmitters and hormones is one of the important features of neuroendocrine cells, regulated by G protein-coupled membrane receptors [48]. Gng10 encodes a subunit of G protein that is involved in the regulation of the cell cycle.…”

Section: Discussionmentioning

confidence: 99%

Experimental Evidence of Buyang Huanwu Decoction and Related Modern Preparations (Naoxintong Capsule and Yangyin Tongnao Granule) in Treating Cerebral Ischemia: Intestinal Microorganisms and Transcriptomics in Rats

Yin

Yang

Zhao

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. The traditional Chinese medicines of Buyang Huanwu decoction (BYHW), Naoxintong capsule (NXT), and Yangyin Tongnao granules (YYTN) have excellent effects in preventing and treating cerebrovascular disease and are widely tolerated by patients. However, their effects on middle cerebral artery occlusion (MCAO) remain unknown. Methods. We evaluated gut microbiota alterations, the brain transcriptome, and nerve cell responses in rats with MCAO. Results. Our results showed that BYHW, NXT, and YYTN not only effectively improved the damaged state of blood vessels in rats and restored nerve function, but also improved survival. Additional experiments showed that treatment with BYHW, NXT, and YYTN regulated the intestinal microflora. Transcriptome analyses showed that BYHW, NXT, and YYTN modulated the transcriptome of rats with MCAO. The common mechanism of the three prescriptions for the treatment of cerebral ischemia may be related to the intestinal flora regulation of 60S ribosomal protein L18 (Rpl18), eukaryotic translation initiation factor 3 subunit, Ras homolog family member C, G protein subunit gamma 13 (Gng13), and Gng10 genes, among which Rpl18 is the most important. In addition, the three prescriptions had great specificity as anticerebral ischemia targets. Moreover, BYHW, NXT, and YYTN mitigated MCAO-induced hyperactivation of microglia and astrocytes. Conclusion. This study provides a foundation for further research on the mechanisms and treatment of IS. The results strongly suggest that key gut microbiota can be used to study functional genomics of brain, leading to novel discoveries about key genes involved in important biological processes.

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“…Social defeat stress has been reported to increase the number of CRF immunoreactive neurons in Barrington's nucleus (Wood et al, 2009), with administration of a CRF1 antagonist to social defeat mice restoring urodynamic function without affecting CRF expression in the control center (Wood et al, 2013). CRF is also distributed in visceral organs including the bladder, with serum and bladder CRF expression also increased by psychological stress in rats (Seki et al, 2019). This suggests that central, as well as local bladder changes, contribute to alterations in voiding behavior with social defeat.…”

Section: Discussionmentioning

confidence: 99%

Voiding Behavior and Efferent Bladder Function Altered in Mice Following Social Defeat but Not Witness Trauma

et al. 2020

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Psychological stress is associated with bladder dysfunction, however, the local bladder mechanisms affected are not well understood. This study aimed to determine how psychological stress, caused by social defeat or witness trauma, affects voiding behavior and bladder function. Pairs of male C57Bl/6J mice were placed in a custom-made plexiglass chamber with an aggressor ARC(S) mouse for 1 h/day for 10 days. The social defeat mouse was in physical contact with the aggressor, while the witness was physically separated but could observe interactions between its cage-mate and the aggressor. Age matched control pairs were used for comparison. Voiding analysis was conducted periodically over the 10 days. An ex vivo whole bladder preparation was used to assess functional changes after the period of stress. Plasma corticosterone levels were significantly increased by both social defeat and witness trauma stress when compared to unstressed controls. Voiding analysis revealed a significant decrease in voiding frequency in the social defeat group compared to control animals, indicating an altered voiding phenotype. Witness trauma did not alter voiding behavior. Bladder contractile responses to cholinergic stimulation were not significantly altered in either stress group, nor was relaxation to the beta-adrenoceptor agonist isoprenaline. However, nerve evoked contractile responses were significantly increased at all frequencies in bladders from social defeat but not witness trauma mice. Purinergic contractile responses were also significantly enhanced in this group. Social defeat also resulted in increased urothelial acetylcholine release during bladder distension, with no change in ATP release. In conclusion, functional bladder changes are dependent upon stressor type. Enhanced urothelial acetylcholine may desensitize bladder sensory nerves, which, coupled with more efficient voiding contractions due to enhanced nervemediated and purinergic detrusor responses, may account for the altered voiding phenotype observed. This study reports a male model of social defeat stress with reduced urinary frequency, with no voiding changes observed in the witness.

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Role of corticotropin-releasing factor on bladder function in rats with psychological stress

Cited by 4 publications

References 0 publications

Beyond depression and anxiety; a systematic review about the role of corticotropin-releasing hormone antagonists in diseases of the pelvic and abdominal organs

Beyond depression and anxiety; a systematic review about the role of corticotropin-releasing hormone antagonists in diseases of the pelvic and abdominal organs

Experimental Evidence of Buyang Huanwu Decoction and Related Modern Preparations (Naoxintong Capsule and Yangyin Tongnao Granule) in Treating Cerebral Ischemia: Intestinal Microorganisms and Transcriptomics in Rats

Voiding Behavior and Efferent Bladder Function Altered in Mice Following Social Defeat but Not Witness Trauma

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