Role of conventional oral antidiabetic drugs in management of type 2 diabetes mellitus

Thakare, Vaishali; Shende, Shrikrishna; Shirure, Prashant A.; Swami, Onkar C

doi:10.18203/2320-6012.ijrms20170619

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Insulin is not the only treatment of DM; there were many known oral medications that help to lower elevated blood glucose levels such as glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase 4 inhibitors (Thakare, Shende, Shirure, & Swami, 2017). Mostly, these drugs have adverse unwanted effects which necessitate the need for new modalities like natural products to replace those (Hossen, Gan, & Khalil, 2017).…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic effect of the Egyptian honey bee (Apis mellifera) venom in alloxan-induced diabetic rats

Hassan

El-kotby

Tawfik

et al. 2019

JoBAZ

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Background: Diabetes mellitus (DM) is one of the most common endocrinal diseases characterized by hyperglycemia and altered metabolism of lipids, carbohydrates, and proteins with an increased risk of many complications. Bioactive drugs extracted from natural sources had been used in a wide range of treatment for many diseases. This work aimed to investigate the potential antidiabetic effect of Egyptian honey bee venom (BV) in alloxan-induced diabetic rats. Subjects and methods: Forty adult male albino rats (140-180 g) were used in the study and divided into five groups each of eight rats. The normal control group, diabetic group, high-and low-dose BV-treated groups, and vildagliptintreated group. Blood samples and pancreases were collected after 6 weeks of the experiment. Results: Treatment of diabetic rats with BV revealed a significant decrease in serum glucose level accompanied by a significant increase in insulin level. Malondialdehyde (MDA), cholesterol, triglycerides, creatinine, and aminotransferases (ALT and AST) levels were significantly decreased after BV treatment in comparison with diabetic animals. Total antioxidant capacity (TAC), glutathione (GSH) contents, and catalase (CAT) activity had improved. Histological examination of the pancreas indicated a marked improvement in the islet architecture and marked regeneration of insulin-secreting β-cell in diabetic BV-treated rats. Conclusion: The study concluded that BV could have the ability to lower glucose level in diabetic rats and enhance insulin secretion, and relieved the various biochemical and histological abnormalities resulted due to diabetes metabolic disorders.

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Section: Introductionmentioning

confidence: 99%

Antidiabetic effect of the Egyptian honey bee (Apis mellifera) venom in alloxan-induced diabetic rats

Hassan

El-kotby

Tawfik

et al. 2019

JoBAZ

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“…Researchers are equally interested in antidiabetic drugs that target incretin pathway. Incretins are hormones predominantly glucose-dependent insulin tropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1) produced by the intestinal mucosa that enhance glucose-induced insulin secretion and lower blood glucose concentration levels (Thakare et al 2017). About 60% of the insulin release in the body is through incretin pathway via the activity of GLP-1 and GIP (Salehi et al 2012).…”

Section: Introductionmentioning

confidence: 99%

In-vitro anti-diabetic activity and in-silico studies of binding energies of palmatine with alpha-amylase, alpha-glucosidase and DPP-IV enzymes

Okechukwu¹,

Sharma²,

Tan³

et al. 2020

PHAR

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Palmatine a protoberberine alkaloid has been previously reported to possess in vivo antidiabetic and antioxidant property. The aim of the experiment is to evaluate the in vitro antidiabetic activity and in-silico studies of the binding energies of Palmatine, acarbose, and Sitagliptin with the three enzymes of alpha-amylase, alpha-glucosidase, and dipeptidyl peptidase-IV (DPP-IV). The in vitro antidiabetic study was done by evaluating the inhibitory effect of palmatine on the activities of alpha-amylase, alpha-glucosidase, and DPP-IV. Acarbose, and sitagliptin was used as standard drug. The molecular docking study was performed to study the binding interactions of palmatine with alpha-glucosidase, a-amylase, and DPP-IV. The binding interactions were compared with the standard compounds Sitagliptin and acarbose. Palmatine with IC50 (1.31 ± 0.27 µM) showed significant difference of (< 0.0001) higher inhibiting effect on alpha-amylase and weak inhibiting effect on alpha-glucosidase enzyme with IC50 (9.39 ± 0.27 µM) and DPP-IV with IC50 (8.7 ± 1.82 µM). Palmatine possess inhibition effect on the three enzymes.

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Apigetrin-enriched Pulmeria alba extract prevents assault of STZ on pancreatic β-cells and neuronal oxidative stress with concomitant attenuation of tissue damage and suppression of inflammation in the brain of diabetic rats

Abdulrasheed-Adeleke¹,

Lawal²,

Agwupuye³

et al. 2023

Biomedicine & Pharmacotherapy

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Role of conventional oral antidiabetic drugs in management of type 2 diabetes mellitus

Cited by 4 publications

References 18 publications

Antidiabetic effect of the Egyptian honey bee (Apis mellifera) venom in alloxan-induced diabetic rats

Antidiabetic effect of the Egyptian honey bee (Apis mellifera) venom in alloxan-induced diabetic rats

In-vitro anti-diabetic activity and in-silico studies of binding energies of palmatine with alpha-amylase, alpha-glucosidase and DPP-IV enzymes

Apigetrin-enriched Pulmeria alba extract prevents assault of STZ on pancreatic β-cells and neuronal oxidative stress with concomitant attenuation of tissue damage and suppression of inflammation in the brain of diabetic rats

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