Role of contrast-enhanced FLAIR MRI in diagnosis of intracranial lesions

Mustafa, Wessam; Ali, S. A.; Elgendy, Nadia; Salama, Samer; sorogy, Lamiaa El; Mohsen, Mohamed

doi:10.1186/s41983-021-00360-x

Cited by 6 publications

(4 citation statements)

References 15 publications

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“…Our results showed significantly higher lesion SI on CE-FLAIR images compared to pre contrast ones and this proved the presence of lesion enhancement on CE-FLAIR images, for observer one, the mean CEI was 88 ranging from 0.5 to 651, for observer two, the mean CEI was 83 ranging from 0.5 to 651 (ICC = 0.959, 95% CI 0.933-0.975). These results were in line with another study [19] which found higher CEI in CE-FLAIR in comparison with pre-contrast FLAIR images with CEI ~ 262 ranging from 40 up to 1708.…”

Section: Discussionsupporting

confidence: 92%

“…The higher contrast to background ratio on CE-FLAIR can be explained by higher inherent soft tissue contrast resolution in FLAIR compared to T1W sequence. These results were supported by the results of study conducted by Mustafa et al [19] who found higher contrast to background ratio in CE-FLAIR than in CE-T1WI. They found the contrast to background enhancement ratio ranging from 0.2 to 3 in CE-FLAIR compared to 0.05 to 1.2 in CE-T1WI.…”

Section: Discussionsupporting

confidence: 86%

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Contrast enhanced FLAIR versus contrast enhanced T1W images in evaluation of intraparenchymal brain lesions

EL-Adalany

Bilal

Rihan

et al. 2022

Egypt J Radiol Nucl Med

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Background Patients with suspected brain lesions are usually evaluated by means of intravenous contrast materials. These lesions may demonstrate enhancement through different mechanisms. At most institutions, CE-T1WI is the preferred sequence. FLAIR is a sort of inversion recovery pulse sequence with a long TR, TE and T1 and hence effectually nulls signals from CSF. The long T1 causes mild T effect and this result in lesion enhancement on post-contrast study. Therefore, lesions demonstrating enhancement on CE-T1WI will also demonstrate enhancement on CE-FLAIR images. The purpose of this work was to assess the role of CE-FLAIR versus CE-T1WI in evaluation of different intraparenchymal brain lesions. Results Comparing CE-T1WI to CE-FLAIR in various brain pathologies, both observers found higher sensitivity and specificity for lesion to background contrast ratio on CE-FLAIR comparing to CE-T1WI. Observer 1 found that lesion to background contrast ratio on CE-FLAIR had sensitivity of 71.4%, specificity of 66.7% and AUC of 0.661 versus 63.3% sensitivity, 58.3% specificity and 0.634 AUC for CE-T1WI. Observer 2 found that lesion to background contrast ratio on CE-FLAIR had sensitivity of 77.6%, specificity of 66.7% and AUC of 0.719 versus 61.2% sensitivity, 50% specificity and 0.628 AUC for CE-T1WI. Conclusion On comparing CE-FLAIR to CE-T1WI, CE-FLAIR display better lesion detection and enhancement also better soft tissue contrast resolution.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 86%

Contrast enhanced FLAIR versus contrast enhanced T1W images in evaluation of intraparenchymal brain lesions

EL-Adalany

Bilal

Rihan

et al. 2022

Egypt J Radiol Nucl Med

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“…For primary non-gestational mediastinal choriocarcinoma, the diagnosis relies on radiological examinations followed by biopsy and histochemical staining 8. In patients with intra-axial brain lesions, contrast-enhanced brain MRI FLAIR images provide better neuroradiological anatomic descriptions 25 26. In our case, the enhancement of the intra-axial midbrain lesion was more conspicuous using this sequence.…”

Section: Discussionmentioning

confidence: 76%

Primary non-gestational mediastinal choriocarcinoma metastatic to the brainstem

et al. 2022

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Choriocarcinoma is a highly malignant tumour emerging from the syncytiotrophoblast divided into gestational and non-gestational presentations. Primary choriocarcinoma of the mediastinum is rare. Metastases to the brain often occur; however, brainstem involvement has not been reported for non-gestational choriocarcinoma. We described a middle-aged man who developed a complete left oculomotor nerve paralysis secondary to a brainstem tumour at the midbrain. The workup for the primary source of the brainstem tumour included a chest CT scan, which revealed a mediastinal mass. A mediastinal mass needle biopsy confirmed the diagnosis of primary mediastinal choriocarcinoma. Despite aggressive chemotherapy, the patient died 6 months after the initial presentation from neurological complications and multiorgan failure.

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“…In T1-weighted sequences (T1w), contrast-enhancing components can quantify the disruption volume of the blood-brain barrier (BBB), allowing for the detection of malignant tumors. T2-FLAIR-weighted images demonstrate abnormalities resulting from a combination of non-enhancing tumors, subfocal edema, and treatment-related changes (gliosis, leukoencephalopathy, and necrosis) [22,23]. Despite this, this technique has several limitations.…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Application of Metabolic Reprogramming to Cancer Imaging and Diagnosis

Yang

Cai

et al. 2022

IJMS

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Cellular metabolism governs the signaling that supports physiological mechanisms and homeostasis in an individual, including neuronal transmission, wound healing, and circadian clock manipulation. Various factors have been linked to abnormal metabolic reprogramming, including gene mutations, epigenetic modifications, altered protein epitopes, and their involvement in the development of disease, including cancer. The presence of multiple distinct hallmarks and the resulting cellular reprogramming process have gradually revealed that these metabolism-related molecules may be able to be used to track or prevent the progression of cancer. Consequently, translational medicines have been developed using metabolic substrates, precursors, and other products depending on their biochemical mechanism of action. It is important to note that these metabolic analogs can also be used for imaging and therapeutic purposes in addition to competing for metabolic functions. In particular, due to their isotopic labeling, these compounds may also be used to localize and visualize tumor cells after uptake. In this review, the current development status, applicability, and limitations of compounds targeting metabolic reprogramming are described, as well as the imaging platforms that are most suitable for each compound and the types of cancer to which they are most appropriate.

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Role of contrast-enhanced FLAIR MRI in diagnosis of intracranial lesions

Cited by 6 publications

References 15 publications

Contrast enhanced FLAIR versus contrast enhanced T1W images in evaluation of intraparenchymal brain lesions

Contrast enhanced FLAIR versus contrast enhanced T1W images in evaluation of intraparenchymal brain lesions

Primary non-gestational mediastinal choriocarcinoma metastatic to the brainstem

Application of Metabolic Reprogramming to Cancer Imaging and Diagnosis

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