Role of Consolidative Proton Radiotherapy following Chemotherapy for Pediatric Hodgkin Lymphoma: A Single-Institution Experience

Abstract

On univariate analysis, neither OS nor PFS were associated with any recorded patient characteristic including GTV size, age at diagnosis, type of surgery, receipt of chemotherapy or cumulative RT dose. 8 patients had distant failures; 6 had marginal failures. The remaining patients who had progressed prior to last analysis failed locally. Of the 8 patients with distant failure, 6 had leptomeningeal disease (LMD). Half of the patients with LMD had PTEN deletions. 5 of the 8 patients with distant failures had MIB-1 staining results, all with values below or equal to 50%. Additional molecular testing for patients in the entire cohort is ongoing and will be correlated with patterns of failure and survival. Conclusion: Pediatric high-grade gliomas are comprised of diverse mutational signatures, which may be associated with tumor aggressiveness and potential for treatment response. Molecular phenotyping of pediatric high-grade gliomas may provide valuable prognostic information that could inform treatment decision-making.