Role of conization in the detection and treatment of cervical carcinoma in situ

Krieger, James S.; McCormack, Lawrence J.; Bradley, Vernon F.

doi:10.1016/0002-9378(63)90083-8

Cited by 32 publications

(4 citation statements)

References 7 publications

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“…The first to propose that a cone with margins free from atypic cells was treatment enough for CIS irrespective of age and desire for further childbirth were Enterline and Krieger & McCormack (118,219,220, Their proposal prompted several investigators to study the frequency of persistent disease in hysterectomy specimens after conization (23,48,103,126,144,146,159,161,181,258,264,278,307,309,334,341,344,350,370,393,405). Reported figures vary between 10 and 70%.…”

Section: Gdran Larssonmentioning

confidence: 99%

Conization for Preinvasive and Early Invasive Carcinoma of the Uterine Cervix

Larsson

1983

Acta Obstet Gynecol Scand

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Section: Gdran Larssonmentioning

confidence: 99%

Conization for Preinvasive and Early Invasive Carcinoma of the Uterine Cervix

Larsson

1983

Acta Obstet Gynecol Scand

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“…Increased knowledge on the biological behaviour of cervical epithelial dysplasia and carcinoma in situ has lead to recommendations of a more conservative management of such lesions (Ahlgren, Ingemarsson, Lindberg & Nordqvist 1975 Krieger, McCormack & Bradley 1963, McLaren 1967. Follow-up investigations have shown that, in up to 97% of the cases, conization alone permanently eradicates all affected areas (Kolstad & Klem 1967).…”

Section: Introductionmentioning

confidence: 99%

Big cones and little cones

et al. 1978

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To investigate whether the amount of tissue removed at conization could influence the frequency of inadequate excision of cervical atypias, 354 cone specimens were measured. The data indicate that the frequency of lesions incompletely removed at conization increased with decreasing size (ie. length and volume) of the specimen. The parameters influencing the detection of epithelial atypias at the surgical margin of the specimens are discussed. A plea is made for international standardization in reporting results of conization (size of cone and number of sections) in order to permit objective comparison between clinics of the results of the conization procedure.

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“…It must be emphasized that a cone biopsy with a multisection technique study is essential for the diagnosis of microinvasive carcinoma of the cervix. Punch biopsy is not adequate and accurate for diagnosis of minimal stromal invasion (41,69,70,72,73). The aggressiveness of therapy depends upon the calculated risk of spread.…”

Section: Agementioning

confidence: 99%