Behavioral interventions have been shown to have powerful effects on human behavior both outside of and within the context of health care. As organizations increasingly adopt behavioral architecture, care must be taken to consider its potential negative consequences. An evidencedbased approach is best, whereby interventions that might have a significant deleterious effect on patients' health outcomes are first tested and rigorously evaluated before being systematically rolled out. In the case of clinical decision support, brief and thorough instructions should be provided for use. Physician performance when using these systems is best measured relatively, in the context of peers with similar training. Responsibility for errors must be shared with clinical team members and system designers. Case Dr R is an internal medicine resident physician in the medical intensive care unit (MICU) who just admitted Ms M, a 60-year-old woman, for an acute exacerbation of her chronic obstructive pulmonary disease. Based on her worsening respiratory status, Dr R determines that she needs mechanical ventilatory support. Through the hospital's electronic health management system (EHMS) and computerized physician order entry system (CPOE), 1 Dr R automates 2 Ms M's pressure support settings. Later that night, Dr R is paged. Ms M's respiratory status has deteriorated, probably due to ventilator-induced barotrauma. Despite the MICU team's implementation of full corrective and supportive measures, Ms M is pronounced dead 8 hours after being admitted to the MICU. Reasons for Ms M's outcome are investigated by the hospital's patient safety and oversight committee. Members of the committee suspect that Dr R selected ventilator settings that were too high for Ms M. When asked to explain, Dr R admits to feeling terrible and to only now understanding that default settings, 3 presented by the EHMS and selected by colleagues and supervisors in past cases, 1 were not appropriate for Ms M.