Role of Computed Tomography in the Evaluation of Peritoneal Carcinomatosis

Kose, Snehal Ishwar

doi:10.5334/jbsr.2921

Cited by 4 publications

(5 citation statements)

References 73 publications

(90 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1). When imaging for presurgical planning and follow-up, structured reporting utilizing the peritoneal carcinomatosis index (PCI) (which divides the peritoneum into 13 locations including a three-by-three grid over the abdomen and pelvis, upper and lower jejunum, and upper and lower ileum) and necessitating mention of the largest implant sizes and presence of vascular and ureteral involvement has been advocated [5,6]. A comprehensive description such as this is generally not possible in the ED setting.…”

Section: Discussionmentioning

confidence: 99%

ED diagnosis of peritoneal carcinomatosis

Scheinfeld,

Schwartz,

Fink

2024

Emerg Radiol

View full text Add to dashboard Cite

Purpose The goal of our study was to better characterize new CT diagnoses of peritoneal carcinomatosis (PC) in the ED, and to evaluate how to best identify the primary lesion. Prompt identification of the source of the carcinomatosis may allow for the patient to receive early initial care from the correct clinical service. Methods All new CT cases of PC-like appearance identified on CT in the ED from January 2017 through July 2020. Each report and corresponding medical record were manually reviewed. Patient demographics, presence/absence of intravenous contrast, source organ predicted by the radiologist in the CT scan report, pathologic diagnosis, and amount of ascites were tabulated. Chi-tests were used to test the statistical significance of differences between groups. Results Of the 131 CT cases of new PC-like appearance which received workup, 108 cases had pathologically proven PC and 23 cases had no underlying malignancy yielding a positive predictive value for actual PC of 82%. The most common cause of new PC in women was gynecological (66%), and in men was of GI tract origin (57%). Concordance between radiologist prediction and final pathology was higher with intravenous contrast (58%) compared to without contrast (40%); although this difference was not statistically significant (p = 0.19). A moderate or large amount of ascites was found in more than half of GYN primaries and in adenocarcinoma of unknown primary and there was a statistically significant difference in amount of ascites between cancer primaries (p = 0.01). Conclusion A PC-like appearance on CT in the ED will likely be in patients with known malignancy, but of the new cases, there is a high PPV for it to represent new peritoneal carcinomatosis. Gynecological and GI malignancies are the most common cause in women and men, respectively, and this may help in focusing the radiologist’s search pattern. Usage of intravenous contrast may help in identifying a primary lesion, and the presence of high-volume ascites should suggest a GYN primary or adenocarcinoma of unknown primary when there is no other obvious primary lesion.

show abstract

Section: Discussionmentioning

confidence: 99%

ED diagnosis of peritoneal carcinomatosis

Scheinfeld,

Schwartz,

Fink

2024

Emerg Radiol

View full text Add to dashboard Cite

show abstract

“…The presence of ascites, positive ascites cytology, and recognition of peritoneal lesions on CT scans provide data that can lead to the diagnosis of peritoneal metastases in breast cancer. [37–42]…”

Section: Discussionmentioning

confidence: 99%

Review of the relationship between tumor receptor subtypes and preference for visceral and/or serosal metastasis in breast cancer patients

Özdemir Akdur,

Çiledağ

2023

Medicine

View full text Add to dashboard Cite

In this study, we investigated the molecular phenotype–cancer relationship that may favor the main metastatic tendencies of cancer by comparing the association of receptor subtypes with the presence of metastasis, serosal metastasis, and/or visceral metastases in patients diagnosed with breast cancer. In this study, we retrospectively evaluated 853 patients who were diagnosed with breast cancer and followed up at our hospital between 2017 and 2022. The probability of metastasis in the most common tumor group, the non-special type of invasive carcinoma was significantly higher than that in other tumor groups. We formed our groups according to estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki67 status. In addition, when we compared the receptor groups, no significant difference was found between the receptor groups (Table 1). When the entire breast cancer cohort was considered, the association of serosal metastasis was statistically significantly higher in the ER and/or PR (+) and, HER2 (−) receptor subgroup than in all other receptor groups (P < .006), and the association of visceral metastasis/visceral + serosal metastasis with the ER and/or PR (+) and, HER2 (−) receptor subgroup was significantly higher than that in all other receptor groups (P < .001) (Table 2). In this study, we aimed to investigate the possible relationship between molecular markers of the primary tumor and the preference for serosal and visceral metastases over distant metastases in a large cohort of patients to contribute to the improvement of the diagnosis and treatment of breast cancer, a heterogeneous disease group. To the best of our knowledge, our study is the first to statistically investigate the association between receptor subgroups and visceral, serosal, and serosal + visceral metastases as a group and to reach some conclusions.

show abstract

“…Strengths of the procedure include wide availability, low cost, high spatial resolution, short scanning time and the possibility of multiplanar image reconstructions (MPRs) [37].…”

Section: Computed Tomographymentioning

confidence: 99%

“…Such spaces and supporting structures can serve as gateways for intraperitoneal tumor spread and the establishment of carcinomatosis implants [37,64].…”

Section: Diffusion Pathwaysmentioning

confidence: 99%

Imaging of Peritoneal Carcinomatosis in Advanced Ovarian Cancer: CT, MRI, Radiomic Features and Resectability Criteria

Miceli,

Gennarini,

Tomao

et al. 2023

Cancers

View full text Add to dashboard Cite

PC represents the most striking picture of the loco-regional spread of ovarian cancer, configuring stage III. In the last few years, many papers have evaluated the role of imaging and therapeutic management in patients with ovarian cancer and PC. This paper summed up the literature on traditional approaches to the imaging of peritoneal carcinomatosis in advanced ovarian cancer, presenting classification systems, most frequent patterns, routes of spread and sites that are difficult to identify. The role of imaging in diagnosis was investigated, with particular attention to the reported sensitivity and specificity data—computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography-CT (PET-CT)—and to the peritoneal cancer index (PCI). In addition, we explored the therapeutic possibilities and radiomics applications that can impact management of patients with ovarian cancer. Careful staging is mandatory, and patient selection is one of the most important factors influencing complete cytoreduction (CCR) outcome: an accurate pre-operative imaging may allow selection of patients that may benefit most from primary cytoreductive surgery.

show abstract

Role of Computed Tomography in the Evaluation of Peritoneal Carcinomatosis

Cited by 4 publications

References 73 publications

ED diagnosis of peritoneal carcinomatosis

ED diagnosis of peritoneal carcinomatosis

Review of the relationship between tumor receptor subtypes and preference for visceral and/or serosal metastasis in breast cancer patients

Imaging of Peritoneal Carcinomatosis in Advanced Ovarian Cancer: CT, MRI, Radiomic Features and Resectability Criteria

Contact Info

Product

Resources

About