Role of competitive endogenous RNA networks in the pathogenesis of coronary artery disease

Zuo, Jiebin; Xu, Mengxi; Wang, Danning; Bai, Weizhe; Li, Gang

doi:10.21037/atm-21-2737

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…Activation of the PI3K/Akt signaling pathway is well known to accelerate the development of atherosclerosis ( 52 ). As suggested by a recently published study ( 53 ), this pathway plays an important role in the pathology of CAD. The affected proteins play functional roles in biological processes of peptidyl-tyrosine modification, innate immune response-activating signal transduction, positive regulation of cell migration, MAPK cascade, blood coagulation and so on.…”

Section: Discussionmentioning

confidence: 78%

Coronary artery disease risk factors affected by RNA modification-related genetic variants

Zhang²,

Tang³

et al. 2022

Front. Cardiovasc. Med.

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BackgroundSingle nucleotide polymorphisms that affect RNA modification (RNAm-SNPs) may have functional roles in coronary artery disease (CAD). The aim of this study was to identify RNAm-SNPs in CAD susceptibility loci and highlight potential risk factors.MethodsCAD-associated RNAm-SNPs were identified in the CARDIoGRAMplusC4D and UK Biobank genome-wide association studies. Gene expression and circulating protein levels affected by the RNAm-SNPs were identified by QTL analyses. Cell experiments and Mendelian randomization (MR) methods were applied to test whether the gene expression levels were associated with CAD.ResultsWe identified 81 RNAm-SNPs that were associated with CAD or acute myocardial infarction (AMI), including m6A-, m1A-, m5C-, A-to-I- and m7G-related SNPs. The m6A-SNPs rs3739998 in JCAD, rs148172130 in RPL14 and rs12190287 in TCF21 and the m7G-SNP rs186643756 in PVT1 were genome-wide significant. The RNAm-SNPs were associated with gene expression (e.g., MRAS, DHX36, TCF21, JCAD and SH2B3), and the expression levels were associated with CAD. Differential m6A methylation and differential expression in FTO-overexpressing human aorta smooth muscle cells and peripheral blood mononuclear cells of CAD patients and controls were detected. The RNAm-SNPs were associated with circulating levels of proteins with specific biological functions, such as blood coagulation, and the proteins (e.g., cardiotrophin-1) were confirmed to be associated with CAD and AMI in MR analyses.ConclusionThe present study identified RNAm-SNPs in CAD susceptibility genes, gene expression and circulating proteins as risk factors for CAD and suggested that RNA modification may play a role in the pathogenesis of CAD.

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Section: Discussionmentioning

confidence: 78%

Coronary artery disease risk factors affected by RNA modification-related genetic variants

Zhang²,

Tang³

et al. 2022

Front. Cardiovasc. Med.

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“…The increase in apoptosis is attributed to a decrease in MDM2 and increase in p53 signal transduction [ 32 ]. Disruption of this regulatory mechanism can lead to excessive cell growth [ 33 ]. Studies demonstrated that MDM2 inhibition can reduce cardiac dysfunction and fibrosis following myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

Effect of Dan-Lou tablets on coronary heart disease revealed by microarray analysis integrated with molecular mechanism studies

Li¹,

Cheng²,

He³

et al. 2023

Heliyon

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LncRNA-mediated Modulation of Endothelial Cells: Novel Progress in the Pathogenesis of Coronary Atherosclerotic Disease

Ouyang

Zhou

Liu

et al. 2024

CMC

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Coronary atherosclerotic disease (CAD) is a common cardiovascular disease and an important cause of death. Moreover, endothelial cells (ECs) injury is an early pathophysiological feature of CAD, and long noncoding RNAs (lncRNAs) can modulate gene expression. Recent studies have shown that lncRNAs are involved in the pathogenesis of CAD, especially by regulating ECs. In this review, we summarize the novel progress of lncRNA-modulated ECs in the pathogenesis of CAD, including ECs proliferation, migration, adhesion, angiogenesis, inflammation, apoptosis, autophagy, and pyroptosis. Thus, as lncRNAs regulate ECs in CAD, lncRNAs will provide ideal and novel targets for the diagnosis and drug therapy of CAD.

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Role of competitive endogenous RNA networks in the pathogenesis of coronary artery disease

Cited by 3 publications

References 37 publications

Coronary artery disease risk factors affected by RNA modification-related genetic variants

Coronary artery disease risk factors affected by RNA modification-related genetic variants

Effect of Dan-Lou tablets on coronary heart disease revealed by microarray analysis integrated with molecular mechanism studies

LncRNA-mediated Modulation of Endothelial Cells: Novel Progress in the Pathogenesis of Coronary Atherosclerotic Disease

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