Role of Circadian Rhythms in Potassium Homeostasis

Gumz, Michelle L.; Rabinowitz, L.

doi:10.1016/j.semnephrol.2013.04.003

Cited by 51 publications

(26 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a steady state, kidneys excrete approximately 95% of dietary K + , and the remainder is excreted through the gastrointestinal system. [27] and intestinal K + exposure [28] , independent of aldosterone and serum K + concentrations.…”

Section: Potassium Regulation and Dyskalemiamentioning

confidence: 95%

Acid-Base and Electrolyte Disorders in Patients with and without Chronic Kidney Disease: An Update

Dhondup¹,

Qian²

2017

Kidney Dis

View full text Add to dashboard Cite

Kidneys play a pivotal role in the maintenance and regulation of acid-base and electrolyte homeostasis, which is the prerequisite for numerous metabolic processes and organ functions in the human body. Chronic kidney diseases compromise the regulatory functions, resulting in alterations in electrolyte and acid-base balance that can be life-threatening. In this review, we discuss the renal regulations of electrolyte and acid-base balance and several common disorders including metabolic acidosis, alkalosis, dysnatremia, dyskalemia, and dysmagnesemia. Common disorders in chronic kidney disease are also discussed. The most recent and relevant advances on pathophysiology, clinical characteristics, diagnosis, and management of these conditions have been incorporated.

show abstract

Section: Potassium Regulation and Dyskalemiamentioning

confidence: 95%

Acid-Base and Electrolyte Disorders in Patients with and without Chronic Kidney Disease: An Update

Dhondup¹,

Qian²

2017

Kidney Dis

View full text Add to dashboard Cite

show abstract

“…However, even when K 1 intake and activity are evenly spread over a 24-hour period, there remains a circadian rhythm whereby K 1 excretion is lower at night and in the early morning hours and then increases in the afternoon (83)(84)(85)(86). This circadian pattern results from changes in intratubular K 1 concentration in the collecting duct as opposed to variations in urine flow rate (87).…”

Section: Circadian Rhythm Of K 1 Secretionmentioning

confidence: 99%

Regulation of Potassium Homeostasis

Palmer

2015

Clinical Journal of the American Society of Nephrology

402

335

View full text Add to dashboard Cite

Potassium is the most abundant cation in the intracellular fluid, and maintaining the proper distribution of potassium across the cell membrane is critical for normal cell function. Long-term maintenance of potassium homeostasis is achieved by alterations in renal excretion of potassium in response to variations in intake. Understanding the mechanism and regulatory influences governing the internal distribution and renal clearance of potassium under normal circumstances can provide a framework for approaching disorders of potassium commonly encountered in clinical practice. This paper reviews key aspects of the normal regulation of potassium metabolism and is designed to serve as a readily accessible review for the well informed clinician as well as a resource for teaching trainees and medical students.

show abstract

“…In humans, the ratio of peak-to-minimum K + excretion is approximately 5:1. 16 Although it might be thought that this relates entirely to dietary intake patterns or plasma [K + ], this rhythm is maintained, even when diurnal variations in activity, posture, and dietary intake are perturbed, providing evidence that it is related to central clock mechanisms. 16 This type of response has been termed predictive in contrast to reactive, 17 in that it primes the system in anticipation of the need to excrete K + .…”

Section: Renal K + Handlingmentioning

confidence: 99%

Potassium and Its Discontents

Ellison

Terker

Gamba

2016

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Hyperkalemia is common in patients with impaired kidney function or who take drugs that inhibit the renin-angiotensin-aldosterone axis. During the past decade, substantial advances in understanding how the body controls potassium excretion have been made, which may lead to improved standard of care for these patients. Renal potassium disposition is primarily handled by a short segment of the nephron, comprising part of the distal convoluted tubule and the connecting tubule, and regulation results from the interplay between aldosterone and plasma potassium. When dietary potassium intake and plasma potassium are low, the electroneutral sodium chloride cotransporter is activated, leading to salt retention. This effect limits sodium delivery to potassium secretory segments, limiting potassium losses. In contrast, when dietary potassium intake is high, aldosterone is stimulated. Simultaneously, potassium inhibits the sodium chloride cotransporter. Because more sodium is then delivered to potassium secretory segments, primed by aldosterone, kaliuresis results. When these processes are disrupted, hyperkalemia results. Recently, new agents capable of removing potassium from the body and treating hyperkalemia have been tested in clinical trials. This development suggests that more effective and safer approaches to the prevention and treatment of hyperkalemia may be on the horizon.

show abstract

Role of Circadian Rhythms in Potassium Homeostasis

Cited by 51 publications

References 51 publications

Acid-Base and Electrolyte Disorders in Patients with and without Chronic Kidney Disease: An Update

Acid-Base and Electrolyte Disorders in Patients with and without Chronic Kidney Disease: An Update

Regulation of Potassium Homeostasis

Potassium and Its Discontents

Contact Info

Product

Resources

About