Abstract:Background and PurposeThe role of circadian locomotor output cycles kaput (CLOCK) in regulating drug chronoefficacy and chronotoxicity remains elusive. Here, we aimed to uncover the impact of CLOCK and dosing time on clopidogrel efficacy and toxicity.Experimental ApproachThe antiplatelet effect, toxicity and pharmacokinetics experiments were conducted with Clock−/− mice and wild‐type mice, after gavage administration of clopidogrel at different circadian time points. The expression levels of drug‐metabolizing … Show more
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