Role of chromatin modulation in the establishment of protozoan parasite infection for developing targeted chemotherapeutics

Impact of epigenetics on human health and possible tool for remediation

“…Some have even tried to correlate the known signatures and their potency to act as therapeutic targets. For example, Ghosh et al points that although some HDAC inhibitors used to treat HIV are being considered as diagnostic tool for parasitic infection; they may be of concern in some infection mechanisms HDAC is naturally suppressed so as to increase parasitic proliferation in the host [17]. Interestingly, HDACi mediated therapies have suggested in treatment of several neurological disorders like Alzheimer's and as suggested by Jasrotia et al, may be considered for relieving individuals from migraine [26].…”