Role of Cholinergic and Cytokine Regulation of T Cell Function in Stimulation and Inhibition of Immune Reactions in Intoxication by Organophosphorus Compounds in Different Doses

Abstract

Experiments on outbred albino rats showed that administration of acetylcholine and aceclidine in a dose of 0.1 LD 50 for 3 days and of dimethyl dichlorovinyl phosphate (organophosphorus compound) in a single dose of 0.05 LD 50 stimulated the function of Th1 and Th2 lymphocytes and cytokine production by these cells. Dimethyl dichlorovinyl phosphate in a single dose of 0.5 LD 50 produced an opposite effect. Acetylcholine and aceclidine stimulated activity of acetylcholinesterase in T cells, while dimethyl dichlorovinyl phosphate in a single dose of 0.5 LD 50 inhibited it. During acute intoxication, the organophosphorus compound, depending on the dose, can stimulate (acetylcholine effect) and inhibit the immune reactions (acetylcholinesterase inhibition of T cells).