Role of Cholesterol in Interaction of Ionic Liquids with Model Lipid Membranes and Associated Permeability
Sandeep Kumar,
Navleen Kaur,
Prashant Hitaishi
et al.
Abstract:In this work, we
explored how the amount of cholesterol
in the
lipid membrane composed of phosphatidylcholine (POPC) or phosphatidylglycerol
(POPG) affects the interaction with 1-dodecyl-3-methylimidazolium
bromide ([C12MIM]+Br–) ionic
liquids using various biophysical techniques. On interacting with
the membrane, [C12MIM]+Br– leads to enhanced membrane permeability and induces membrane fusion,
leading to an increase in vesicle size. The 2H-based solid-state
NMR investigations of cholesterol-containing lipid m… Show more
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