Role of cholecystokinin in the negative feedback control of pancreatic enzyme secretion in conscious rats

Fölsch, Ulrich R.; Cantor, Per; Wilms, H; Schafmayer, A.; Becker, H. D.; Creutzfeldt, W.

doi:10.1016/0016-5085(87)90141-7

Cited by 174 publications

(68 citation statements)

References 23 publications

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“…In rats, endocrine forms suggested from chromatography of plasma samples and assay of fractions collected have varied from laboratory to laboratory. The major forms reported were CCK-8 (28), CCK-22 (16,34), CCK-33/39 (35,47), and CCK-58 (42,46). An important observation is that endocrine forms smaller than CCK-58 can be produced ex vivo during the processing of plasma samples.…”

mentioning

confidence: 99%

CCK-8 and CCK-58 differ in their effects on nocturnal solid meal pattern in undisturbed rats

Goebel-Stengel

Stengel²,

Wang³

et al. 2012

American Journal of Physiology-Regulatory, Integrative and Comp

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mentioning

confidence: 99%

CCK-8 and CCK-58 differ in their effects on nocturnal solid meal pattern in undisturbed rats

Goebel-Stengel

Stengel²,

Wang³

et al. 2012

American Journal of Physiology-Regulatory, Integrative and Comp

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“…This effect was reversed when intravenous CCK 8 We were unable to demonstrate any beneficial effect on the course of patients with acute pancreatitis with this dose ofpancreatic enzymes.…”

Section: Discussionmentioning

confidence: 55%

“…These effects seem to be located in the upper intestine and mediated by cholecystokinin 3,8,9. The presence of feedback inhibition of pancreatic enzymes by intraduodenal trypsin in man remains controversial.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic Enzyme Supplementation in Acute Pancreatitis

1995

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This study evaluates the effect oforal pancreatic enzyme supplements on pain, analgesic requirement and the incidence ofcomplications in patients with acute pancreatitis. This double blind, prospectively randomised placebo controlled study included 23 patients. Pain was monitored using a visual analogue scale; the analgesic requirement was assessed with a numerical score.No significant differences were noted between the median (range) pain scores of patients who received placebo: 22 (17.1-58) and those who received enzymes: 23 (11.3 -63). Hospital stay was 7 (5-10) days in patients on placebo and 8 (6-24) days in the enzyme group (p 0.069). Analgesic requirements were: placebo 20 (6-60) and enzymes: 16 (0-63) (p 0.56). This study has shown no beneficial effect of oral pancreatic enzyme supplements in the initial management ofpatients with acute pancreatitis.

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“…This is believed to result in increased pancreatic ductal and parenchymal pressure, and hence pain. Several animal 21 and human 22 studies have supported the presence of this regulatory pathway, while others have not. 23,24 The potential pain benefit of PES in CP pain is based on restoring this negative feedback mechanism.…”

Section: Painmentioning

confidence: 99%

Delayed release pancrelipase for treatment of pancreatic exocrine insufficiency associated with chronic pancreatitis

Krishnamurty

Rabiee

Andersen³

2009

TCRM

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Role of cholecystokinin in the negative feedback control of pancreatic enzyme secretion in conscious rats

Cited by 174 publications

References 23 publications

CCK-8 and CCK-58 differ in their effects on nocturnal solid meal pattern in undisturbed rats

CCK-8 and CCK-58 differ in their effects on nocturnal solid meal pattern in undisturbed rats

Pancreatic Enzyme Supplementation in Acute Pancreatitis

Delayed release pancrelipase for treatment of pancreatic exocrine insufficiency associated with chronic pancreatitis

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