Role of childhood adversity in the development of medical co-morbidities associated with bipolar disorder

Abstract

Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. b s t r a c tObjective: A role for childhood adversity in the development of numerous medical conditions in adults has been described in the general population, but has not been examined in patients with bipolar disorder who have multiple medical comorbidities which contribute to their premature mortality. Methods: More than 900 outpatients (average age 41) with bipolar disorder completed questionnaires that included information about the occurrence of verbal, physical, or sexual abuse in childhood and whether their parents had a mood or substance abuse disorder, or a history of suicidality. These factors were combined to form a total childhood adversity score, which was then related to one or more of 30 medical conditions patients rated as present or absent. Results: The child adversity score was significantly related to the total number of medical comorbidities a patient had (po .001), as well as to 11 specific medical conditions that could be modeled in a logistic regression (p o .03). These included: asthma, arthritis, allergies, chronic fatigue syndrome, chronic menstrual irregularities, fibromyalgia, head injury (without loss of consciousness), hypertension, hypotension, irritable bowel syndrome, and migraine headaches. Limitations: The contribution of parental diagnosis to childhood adversity is highly inferential. Conclusions: These data link childhood adversity to the later occurrence of multiple medical conditions in adult outpatients with bipolar disorder. Recognition of these relationships and early treatment intervention may help avert a more severe course of not only bipolar disorder but also of its prominent medical comorbidities and their combined adverse effects on patients'health, wellbeing, and longevity.

Gender Differences, Clinical Correlates, and Longitudinal Outcome of Bipolar Disorder With Comorbid Migraine

“…Childhood maltreatment, trauma and abuse have been found to play a role in developing migraine headache and converting episodic to daily migraine. 6,41,42 Neuroticism was strongly associated with migraine in both genders, and as neuroticism measures propensity to experience negative affect and stress, those with high neuroticism are less likely to be able to be adaptable and flexible in coping styles. 43–45 …”

“…2 In addition, health care for BD costs more on a per capita basis than for depression, asthma, coronary artery disease, or diabetes, 3 and comorbid medical conditions negatively affect quality of life and contribute to the burden of illness. 4–6 Migraine is a common comorbidity of BD. In population-based studies, the rate of migraine in the general population is 9–15%, 7–12 whereas the rate of migraine co-morbidity with BD is 16–54%.…”

A meta-analysis and systematic review of the comorbidity between irritable bowel syndrome and bipolar disorder

“…Eleven articles and 1 trial were screened for eligibility, of which 1 did not have a control group, [19] 1 did not focus on BD patients, [20] 2 were review articles, [21,22] and 1 was a case report. [23] The trial of NCT02657668 in the ClinicalTrials.gov was excluded because of lack of results of the study.…”

Depression in cancer: The many biobehavioral pathways driving tumor progression

“…Maladaptive habits, including unhealthy diet and smoking, as well as environmental factors, including childhood abuse, have been consistently associated with pro-inflammatory activation 59 . For instance, individuals with a history of childhood abuse exhibit higher plasma CRP, IL-6 and TNF-α levels during adulthood in comparison to healthy controls 60 and are exposed to greater risk of chronic diseases in adulthood including cancer, depression, cardiovascular disease and metabolic syndrome 61 .…”