Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer

Nerviani, Alessandra; Pitzalis, Costantino

doi:10.1002/jlb.3mr0218-062r

Cited by 43 publications

(49 citation statements)

References 99 publications

(252 reference statements)

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“…TLSs have ectopic expression of lymphoid chemokines and cytokines, including LTα, LTβ, CXCL13, CXCL12, CCL21, and CCL19 (98–100). The development and function of TLSs, as well as the cellular players involved have been extensively reviewed elsewhere (96, 97, 99–101) and therefore we will mainly focus on the role of TNFRSF members in TLSs and their associated vessels.…”

Section: Tertiary Lymphoid Structure Formationmentioning

confidence: 99%

The Role of Endothelial Cells and TNF-Receptor Superfamily Members in Lymphoid Organogenesis and Function During Health and Inflammation

et al. 2019

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Lymph nodes (LNs) are crucial for the orchestration of immune responses. LN reactions depend on interactions between incoming and local immune cells, and stromal cells. To mediate these cellular interactions an organized vascular network within the LN exists. In general, the LN vasculature can be divided into two components: blood vessels, which include the specialized high endothelial venules that recruit lymphocytes from the bloodstream, and lymphatic vessels. Signaling via TNF receptor (R) superfamily (SF) members has been implicated as crucial for the development and function of LNs and the LN vasculature. In recent years the role of cell-specific signaling of TNFRSF members in different endothelial cell (EC) subsets and their roles in development and maintenance of lymphoid organs has been elucidated. Here, we discuss recent insights into EC-specific TNFRSF member signaling and highlight its importance in different EC subsets in LN organogenesis and function during health, and in lymphocyte activation and tertiary lymphoid structure formation during inflammation.

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Section: Tertiary Lymphoid Structure Formationmentioning

confidence: 99%

The Role of Endothelial Cells and TNF-Receptor Superfamily Members in Lymphoid Organogenesis and Function During Health and Inflammation

et al. 2019

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“…Their developmental processes seem comparable, including that follicular structures are formed shortly after birth, although their time courses appear to differ each other, considering the proportions to whole gestational period (human: about 35% past, pig: about 57% past). Furthermore, the chemokines we analyzed (CCL19, CCL21 and CXCL13) are considered to be relevant with the formation of lymphoid tissue also in humans [11]. Thus, the pig can be an appropriate model for the research of human tonsil development.…”

Section: Resultsmentioning

confidence: 99%

Fetal and early postnatal development of the porcine tonsils of the soft palate

Suzuki

Fuchimoto

2019

Exp. Anim.

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Tonsils are mucosa-associated lymphoid tissues located at the openings of the gastrointestinal and respiratory tracts, which play a key role in the surveillance of inhaled or ingested pathogens and can concurrently be reservoirs of infectious agents. Therefore, tonsils are important for the immunology and hygiene management of domestic animals, including pigs. However, the process of their fetal developmental has been poorly described, at least in part, because rodents lack tonsils. Therefore, we performed a histological analysis of porcine tonsils of the soft palate from 60 to 100 days of gestation (DG) and from 2 to 14 days post partum (DP). This analysis showed that lymphoid aggregations first appear at DG65, gradually develop during the fetal stage, and expand after birth. In addition, the mRNA expression of chemokine genes involved in lymphoid aggregation and localization was analyzed. CCL19 expression showed the most marked increase and a sharp peak after birth. CCL21 expression changed moderately but showed an interesting bimodal pattern. CXCL13 expression steadily increased throughout the study period. Thus, we demonstrated the mRNA expression of chemokine characteristically changed accompanying tonsillar development.

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“…CCA is characterized by an abundant stromal component, which modulates the biology of cancer cells through a complex intercellular cross-talk, also involving soluble mediators. Chemokines have been shown to regulate the aggressive phenotype of many types of cancer, including CCA [37], inducing a number of biologic actions via interaction with cognate receptors.…”

Section: Discussionmentioning

confidence: 99%

CXCR7 contributes to the aggressive phenotype of cholangiocarcinoma cells

Gentilini

Caligiuri

Raggi

et al. 2019

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

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Development of cholangiocarcinoma (CCA) is dependent on a cross-talk with stromal cells, which release different chemokines including CXCL12, that interacts with two different receptors, CXCR4 and CXCR7. The aim of the present study was to investigate the role of CXCR7 in CCA cells. CXCR7 is overexpressed by different CCA cell lines and in human CCA specimens. Knock-down of CXCR7 in HuCCT-1 cells reduced migration, invasion, and CXCL12-induced adhesion to collagen I. Survival of CCA was also reduced in CXCR7-silenced cells. The ability of CXCL12 to induce cell migration and survival was also blocked by CCX733, a CXCR7 antagonist. Similar effects of CXCR7 activation were observed in CCLP-1 cells and in primary iCCA cells. Enrichment of tumor stem-like cells by a 3D culture system resulted in increased CXCR7 expression compared to cells grown in monolayers, and genetic knockdown of CXCR7 robustly reduced sphere formation both in HuCCT-1 and in CCLP-1 cells. In HuCCT-1 cells CXCR7 was found to interact with β-arrestin 2, which was necessary to mediate CXCL12-induced migration, but not survival. In conclusion, CXCR7 is widely expressed in CCA, and contributes to the aggressive phenotype of CCA cells, inducing cell migration, invasion, adhesion, survival, growth and stem cell-like features. Cell migration induced by CXCR7 requires interaction with β-arrestin 2.

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Role of chemokines in ectopic lymphoid structures formation in autoimmunity and cancer

Cited by 43 publications

References 99 publications

The Role of Endothelial Cells and TNF-Receptor Superfamily Members in Lymphoid Organogenesis and Function During Health and Inflammation

The Role of Endothelial Cells and TNF-Receptor Superfamily Members in Lymphoid Organogenesis and Function During Health and Inflammation

Fetal and early postnatal development of the porcine tonsils of the soft palate

CXCR7 contributes to the aggressive phenotype of cholangiocarcinoma cells

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