Role of chemical structure in stereoselective recognition of β-blockers by cyclodextrins in capillary zone electrophoresis

Gagyi, László; Gyéresi, Árpád; Kilár, Ferenc

doi:10.1016/j.jbbm.2007.10.004

Cited by 30 publications

(21 citation statements)

References 22 publications

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“…12,14,15 The two CDs (RAMEB and HP-β-CD), which exhibited chiral interactions with sotalol enantiomers are derivatized one; have the advantage of a good solubility in aqueous buffers and also exhibit a better selectivity than the native CDs, but are neutral from electrophoretic point of view. Consequently the migrations of sotalol enantiomers will be towards the cathode while the neutral CDs will almost not move, because the EOF in acidic background electrolytes is close to zero.…”

Section: Analytical Performancementioning

confidence: 99%

“…9,10,11 Also chiral separation of sotalol has been studied previously using CZE and CDs derivatives as chiral selectors, the optimal separation conditions significantly differ in several cases, and the basis of the differences has not been clearly identified. 12,13 Taking in consideration all these aspects regarding the strong connections between chirality and therapeutic use of sotalol, elaboration of new methods for its enantiomers separation become a necessity but also a challenge.…”

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confidence: 99%

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Sotalol Chiral Separation by Capillary Electrophoresis

Hancu

Sămărghiţan

Rusu

et al. 2014

J. Chil. Chem. Soc.

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Differences between the pharmaceutical activity among the enantiomers of sotalol are well known, as R-sotalol and S-sotalol have similar antiarrythmic activities but only the R-enantiomer exhibits b-blocking activity. In this study capillary zone electrophoresis was used for the enantiomeric separation of sotalol using different native and derivatized; neutral and charged; cyclodextrines as chiral selectors. The effects of pH value and composition of the background electrolyte, capillary temperature, running voltage and injection parameters have been investigated. The results showed that only the randomly methylated b-cyclodextrine gave a baseline enantiomeric separation under the optimized conditions; chiral interactions being observed also for hydroxypropyl-β-CD and sulfobutyl ether-β-CD. The analytical parameters of the optimized method were verified and the migration order of the two enantiomers was established.

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Section: Analytical Performancementioning

confidence: 99%

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confidence: 99%

Sotalol Chiral Separation by Capillary Electrophoresis

Hancu

Sămărghiţan

Rusu

et al. 2014

J. Chil. Chem. Soc.

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“…Carvedilol, 1-(4-carbazolyloxy)-3-(2-(2-methoxy)ethylamino)-2-propanol [1], has an asymmetric carbon atom, which gives rise to S(-)-and R(+)-enantiomers [2]. It is a non-selective, β-adrenergic receptor antagonist and an α1-adrenoceptor blocker.…”

Section: Introductionmentioning

confidence: 99%

HPLC Method Development and Validation of S(-)-Carvedilol from API and Formulations

Swetha¹,

Chandupatla²,

Veeresham³

2015

AJAC

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A simple chiral HPLC method was developed and validated for quantification of S(-)-Carvedilol in Active Pharmaceutical Ingredient (API) and marketed tablet formulation of racemic Carvedilol. Chiral resolution of enantiomers of Carvedilol was achieved on Phenomenex Lux-cellulose-4 (250 mm × 4.6 mm; 5 µ particle size) chiral column by using a mobile phase, Isopropanol and n-Heptane (60:40 v/v), at a flow rate of 1.0 ml/min and by employing UV detection at 254 nm wavelength. The method was validated according to the ICH guidelines and was proved to be specific, linear, precise and accurate for the analysis of S(-)-Carvedilol.

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“…[2] The methods of analysis of the bulk drugs are officially in the British Pharmacopoeia a potentiometric titration method for both drugs. [3] Several methods have been reported for the analysis of atenolol, including UV spectrophotometry, [4,5] colorimetry, [6] fluorimetry, [7] 1 HNMR, [8] IR, [9] voltammetry, [10,11] potentiometry, [12] TLC, [13,14] HPTLC/ UV detection, [15,16] GC/MS, [17] HPGC/MS, [18] HPLC/UV detection, [19,20] HPLC-tandem mass spectrometry (HPLC/MS/MS), [21,22] ultraperformance liquid chromatography with tandem mass spectrometric (UPLC/MS/MS), [23] HPLC-fluorescence detection, [24] capillary liquid chromatography (CLC) and pressurized capillary electrochromatography (pCEC), [25] CZE, [26,27] miceller electrokinetic chromatography (MEKC) [28] and FIA-UV detection. [29] Reviewing the literature revealed that up to the present time, nothing has been published concerning the chemiluminescence determination of atenolol.…”

Section: Introductionmentioning

confidence: 99%

Determination of enalapril maleate and atenolol in their pharmaceutical products and in biological fluids by flow‐injection chemiluminescence

Alarfaj¹,

Al-Abdulkareem

Aly³

2009

Luminescence

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A chemiluminescent method using flow injection (FI) was investigated for rapid and sensitive determination of enalapril maleate and atenolol, which are used in the treatment of hypertension. The method is based on the sensitizing effect of these drugs on the Ce(IV)-sulfite reaction. The different experimental parameters affecting the chemiluminescence (CL) intensity were carefully studied and incorporated into the procedure. The method permitted the determination of 0.01-3.0 microg mL(-1) of enalapril maleate in bulk form with correlation coefficient r = 0.99993, lower limit of detection (LOD) 0.0025 microg mL(-1) (S/N = 2) and lower limit of quantitation (LOQ) 0.01 microg mL(-1). The linearity range of atenolol in bulk form was 0.01-2.0 microg mL(-1) (r = 0.99989) with LOD of 0.0003 microg mL(-1) (S/N = 2) and LOQ of 0.01 microg mL(-1). In biological fluids the linearity range of enalapril maleate was 0.1-2.0 microg mL(-1) in both urine and serum, and for atenolol the linearity range was 0.1-1.0 microg mL(-1) in both urine and serum. The method was also applied to the determination of the drugs in their pharmaceutical preparations.

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Role of chemical structure in stereoselective recognition of β-blockers by cyclodextrins in capillary zone electrophoresis

Cited by 30 publications

References 22 publications

Sotalol Chiral Separation by Capillary Electrophoresis

Sotalol Chiral Separation by Capillary Electrophoresis

HPLC Method Development and Validation of S(-)-Carvedilol from API and Formulations

Determination of enalapril maleate and atenolol in their pharmaceutical products and in biological fluids by flow‐injection chemiluminescence

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