Role of Characteristics of External Mechanical Stress and Substrate on the Characteristics of Insulin Aggregates
Abstract:The role of chemical nature of the surface and mechanical stress on the properties of insulin in solution kept in the container is explored. The mechanical stress can be applied in the form of shear force or shaking of content in vials. The process of shear can be continuous or intermittent periodic stoppage of shear. We have observed the secondary structures of insulin present over the surface and in the solution. In addition, we have observed the distribution of insulin size, which arises due to their aggreg… Show more
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