Role of Characteristic Components of Humulus lupulus in Promoting Human Health

Abstract

Over the next 50 years, the prevention and control of chronic diseases, such as obesity, cardiovascular disease, Alzheimer's disease, and many cancers, will be one of the most critical challenges in human health. Plant biochemistry and phytonutrient supplements are a promising complementary therapy for the management of chronic disease. Among them, Humulus lupulus has attracted special attention throughout the world because it contains numerous dietary phytochemicals that not only contribute to the aroma and flavor of beer but may also be used for medicinal purposes, as its properties include antiseptic, (an)aphrodisiac, anticancer, antiplatelet, antibacterial, antidiuretic, anti-inflammatory, sedative, hypnotic, and stomachic properties. This review sought to identify and understand the risk factors for chronic disease with a focus on two types of phytochemicals, bitter acids and xanthohumol. The goal was to understand how their metabolites promote human health and reduce the risk of chronic disease.

Promotion of ubiquitination-dependent survivin destruction contributes to xanthohumol-mediated tumor suppression and overcomes radioresistance in human oral squamous cell carcinoma

“…Recently, accumulating evidence indicates that xanthohumol possesses the potent anti-cancer efficacy in various tumor models, such as hepatocellular carcinoma, leukemia, melanoma, non-small cell lung cancer, colorectal, ovarian, pancreatic, and cervical cancer (46). Mechanism study revealed that induction of cell cycle arrest, inhibition of glycolysis, promotion of DNA damage and apoptosis, and suppression of angiogenesis/metastasis are contributed to the anti-tumor activity of xanthohumol (46)(47)(48). Beyond that, the combination of xanthohumol with other therapeutic agents enhanced the tumor-killing effect of chemotherapy in various tumor models (49)(50)(51).…”

Flavonoids as Phytoestrogenic Components of Hops and Beer

“…In traditional medicine, hops have long been used to treat sleep disorders, as a stomach remedy, and as an antibacterial and antifungal agent [ 3 ]. Humulus lupulus attracted special attention because it contains many dietary phytochemicals that can be used for medicinal purposes, due to their antiseptic, (an)aphrodisiac, anticancer, antiplatelet, antidiuretic, antiinflammatory and sedative properties [ 4 ].…”

Quantitative Analysis of Prenylated Constituents in Commercial Hops Samples Using Ultrahigh-Performance Supercritical Fluid Chromatography

“…▶ Table 3 Percentage of prenylated hops compounds (1)(2)(3)(4)(5) in investigated samples (Prod1-6) (n = 3) determined via quantitation using the PDA signal at 220 nm. The calculated recommended daily intake of reference substances in μg per dietary product (Prod1-4) is given in parentheses.…”

“…The flowers (also called cones or hop strobile) of Humulus lupulus L. (Cannabaceae) are not only used for adding aroma and bitterness to beer, but also for their health benefits. Therefore, hop is of interest for both the food and pharmaceutical industry [1]. In 2016, the Committee on Herbal Medicinal Products concluded that on the basis of its long-standing use, hop strobile preparations can be used for mild symptoms of mental stress and to aid sleep (EMA/304 459/2016) [2].…”